An Update on the Insight of Embryonic, Etiopathogenesis, Current Surgical Advances Besides the Advocated ERNICA Guidelines for the Management of Rectosigmoid Hirschsprung Disease, and Clinical Referral Score Model for Early Diagnosis with Future Use of Stem Cells - A Systematic Review

Brown adipose tissue in the form of innovative approach for polycystic ovary syndrome treatmentstill long time to reach clinical arena: a narrative review

“…However maximum work is being pursued at present regarding physical activity, exercise in human PCOS women which indirectly activates BAT thus more stress has to be put on exercises, drug activation using rutin &further try other agents that brown like Berberine resveratrol, curcumin, flavonoids (quercetin)like rutin that has proven to be efficacious. 96…”

“…This organokine further stimulates muscle regeneration, with avoidance of muscle depletion. 24,96 Recently Pehlwani 97 studied the part of rats apelin as well as exercise (45 to 65% VO2max for 6 to 9 weeks) in rats at the time of pregnancy which escalate brown adipose tissue (BAT) proteins like cell death inducing DNA fragmentation factor (Cidea), elongation of very long chain fatty acids like 13 (Elovl3), UCP1, PRDM16, and PGC-1a in males and females foetuses, whereas white adipose tissue (WAT) is diminished. In humans as well as animals apelin along with exercise stimulate the expression of the glucose transporters (GLUT1/2/4) in the muscle in addition to AT via the PI3K/Akt along with AMPK pathways.…”

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“…genetic, metabolic or sociodemographic] to the variations seen. These clarifications might aid in future evidence-based guideline advocates on monitoring and managing PCOS in this era of precision lifestyle medicine [96].…”

“…Kazemi etal. [96], aimed to assess the dietary along with physical activity behaviours in women with and without PCOS. Primary outcomes were inclusive oftotal diet quality, full energy consumption, along with full physical activity [PA], while secondary outcomes were inclusive of macronutrients, micronutrients, food grps, food glycemic indices, time spent sedentarily, as well as sitting.…”

An Update on the Generation of the Gastrointestinal Tract in Neonates with Specific Emphasis on the Hurdles Encountered in Feeding Preterm Infants with Associated Complications like Gut, Brain &G-B Axis Generation: A Narrative Review

“…Occasional studies are present regarding fetal development in addition to early adaptability of the neonates to motility along with barrier functions of the human intestinal mucosa [6].The formation of the functional constituents of the human GIT do not take place concomitantly; Actually the anatomical differentiation of the intestine in general takes place within 20wks GA, functional maturation gets postponed ,needing organized peristalsis in addition to coordination of suckling as well as swallowing ,that do not get marked till 20-30 weeks along with 32-34 weeks respectively [7]. Earlier we reviewed the generation of Hirschsprung Disease, where ENS is not properly developed generation of variable Gut Microbiota (GM) along with environmental factors in particular in early diet patterns in generation of T1D inclusive of TEDDY and other detailed studies, complications associated with preterm birth, role of Gut -Brain axis, GM in the generation of neuropsychiatric diseases like depression ,autistic spectral disorders, schizophrenia, besides impact of altered GM in adult with NPD, along with NDD(Neurodevelopmental diseases) [8][9][10][11][12][13].Thus here we conducted a narrative review regarding the full view of basic intestinal functions existent in the GIT in full term infants as well as preterm infants .Specifically generational variation in intestinal digestion along with absorption working, motility, Gut-Brain axis cross along with microbiome is detailed.…”