An Update on the Effectiveness of Probiotics in the Prevention and Treatment of Cancer

Sankarapandian, Vidya; Maran, Balu Alagar Venmathi; Rajendran, Ramya Lakshmi; Jogalekar, Manasi P.; Sridharan, Gopalan; Krishnamoorthy, Rajapandiyan; Gangadaran, Prakash; Ahn, Byeong‐Cheol

doi:10.3390/life12010059

Cited by 39 publications

(31 citation statements)

References 164 publications

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“…In exploring the roles of these bacteria in the breast, the literature pointed to possible involvement in metabolic pathways. The genus Lactobacillus, including Lactobacillus paracasei, was previously reported to be more common in healthy breast tissues than in cancerous tissues and, because of its immunomodulatory effect, may have a role in BC prevention [19,52]. Lactobacillus vini, generally isolated on organic matrices, was detected as member of human fecal microbiota for the rst time by Rossi et al [53].…”

Section: Discussionmentioning

confidence: 99%

A unique microbiota for normal breast tissue

German

Marino

Hemmerich

et al. 2022

Preprint

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Background Microbial dysbiosis has emerged as a factor in most cancers, including breast cancer. However, whether changes in microbial composition of the breast are a cause, or a consequence, of tumor development remains unclear. Here, we analyzed the microbiota of normal breast tissue (N = 403) by sequencing the nine hypervariable regions of the 16S rRNA gene (V1V2, V2V3, V4V5, V5V7, and V7V9). Results We defined the V1V2 amplicon as optimal for our analysis and identified Lactobacillaceae (Firmicutes phylum), Acetobacterraceae, and Xanthomonadaceae (both Proteobacteria phylum) as the most abundant families in the normal breast. However, Ralstonia (Proteobacteria phylum) was more abundant in breast tumors and histologically normal tissues adjacent to malignant tumors (N = 31 and N = 61, respectively). We also conducted a correlation analysis between the microbiome and known breast cancer risk factors. Abundances of the bacterial taxa Acetotobacter aceti, Lactobacillus vini, Lactobacillus paracasei, and Xanthonomas sp. were associated with age (p < 0.0001), racial background (p < 0.0001), and parity (p < 0.0001). Finally, transcriptome analysis of normal breast tissues showed an enrichment in metabolism- and immune-related genes in the tissues with abundant Acetotobacter aceti, Lactobacillus vini, Lactobacillus paracasei, and Xanthonomas sp., whereas the presence of Ralstonia in the normal tissue was linked to genes involved in the carbohydrate metabolic pathway. Conclusions This study defines the microbial features of normal breast tissue, thus providing a basis to understand cancer-related dysbiosis. Moreover, the findings reveal that lifestyle factors can significantly affect the breast microbial composition.

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Section: Discussionmentioning

confidence: 99%

A unique microbiota for normal breast tissue

German

Marino

Hemmerich

et al. 2022

Preprint

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“…Some probiotic strains can inhibit vacA and flaA virulence genes in H. pylori by producing substances such as reuterin, which is a potent antimicrobial agent expressed by Lactobacillus reuteri ( Urrutia-Baca et al., 2018 ; Song et al., 2019 ). The metabolites produced by the probiotics including PG, surface proteins, secreted proteins, bacteriocins, cell wall polysaccharides, organic acids, hydrogen peroxide, indole, and extracellular vesicles have several favorable effects on the host by triggering various signaling pathways such as mucus secretion in goblet cells ( Teame et al., 2020 ; Sankarapandian et al., 2022 ). Furthermore, many probiotic strains are expected to enrich the human gut, and particular species, such as Lactobacillus spp., can replicate in the human gastric environment and have the ability to prevent H. pylori colonization ( Ji and Yang, 2020 ).…”

Section: Microbiome-based Therapeutic Approaches In Gastric Cancermentioning

confidence: 99%

The interplay between Helicobacter pylori and the gut microbiota: An emerging driver influencing the immune system homeostasis and gastric carcinogenesis

Fakharian

Asgari

Nabavi-Rad

et al. 2022

Front. Cell. Infect. Microbiol.

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The human gut microbiota are critical for preserving the health status because they are required for digestion and nutrient acquisition, the development of the immune system, and energy metabolism. The gut microbial composition is greatly influenced by the colonization of the recalcitrant pathogen Helicobacter pylori (H. pylori) and the conventional antibiotic regimens that follow. H. pylori is considered to be the main microorganism in gastric carcinogenesis, and it appears to be required for the early stages of the process. However, a non-H. pylori microbiota profile is also suggested, primarily in the later stages of tumorigenesis. On the other hand, specific groups of gut microbes may produce beneficial byproducts such as short-chain fatty acids (acetate, butyrate, and propionate) that can modulate inflammation and tumorigenesis pathways. In this review, we aim to present how H. pylori influences the population of the gut microbiota to modify the host immunity and trigger the development of gastric carcinogenesis. We will also highlight the effect of the gut microbiota on immunotherapeutic approaches such as immune checkpoint blockade in cancer treatment to present a perspective for further development of innovative therapeutic paradigms to prevent the progression of H. pylori-induced stomach cancer.

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“…This is because VEGF is a signalling protein that promotes the growth of new blood vessels, while matrix metalloproteinases (MMPs) degrade the extracellular matrix. Hence, postbiotic treatment was able to suppress (VEGF)-MMP2/9 signalling pathway, which in turn helped to reduce the metastasis risk of colon cancer cells [ 83 ]. These findings portray the ability of probiotics, and postbiotics in their antimetastatic ability against various types of cancer cells.…”

Section: The Roles Of Probiotics In Promoting a Balanced Oral Microbi...mentioning

confidence: 99%

The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management

Fuad

Amran

Nasruddin

et al. 2022

Probiotics & Antimicro. Prot.

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Oral carcinogenesis is preceded by oral diseases associated with inflammation such as periodontitis and oral candidiasis, which are contributed by chronic alcoholism, smoking, poor oral hygiene, and microbial infections. Dysbiosis is an imbalance of microbial composition due to oral infection, which has been reported to contribute to oral carcinogenesis. Therefore, in this review, we summarised the role of probiotics, prebiotics, synbiotics, and postbiotics in promoting a balanced oral microbiome, which may prevent oral carcinogenesis due to oral infections. Probiotics have been shown to produce biofilm, which possesses antibacterial activity against oral pathogens. Meanwhile, prebiotics can support growth and increase the benefit of probiotics. In addition, postbiotics possess antibacterial, anticariogenic, and anticancer properties that potentially aid in oral cancer prevention and treatment. The use of probiotics, prebiotics, synbiotics, and postbiotics for oral cancer management is still limited despite their vast potential, thus, discovering their prospects could herald a novel approach to disease prevention and treatment while participating in combating antimicrobial resistance.

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An Update on the Effectiveness of Probiotics in the Prevention and Treatment of Cancer

Cited by 39 publications

References 164 publications

A unique microbiota for normal breast tissue

A unique microbiota for normal breast tissue

The interplay between Helicobacter pylori and the gut microbiota: An emerging driver influencing the immune system homeostasis and gastric carcinogenesis

The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management

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