An Update on the Effect of Clinical Mastitis on the Welfare of Dairy Cows and Potential Therapies

Petersson-Wolfe, Christina S.; Leslie, K.E.; Swartz, T.H.

doi:10.1016/j.cvfa.2018.07.006

Cited by 43 publications

(32 citation statements)

References 47 publications

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“…This improvement aims not only to reduce the antimicrobial usage in dairy cows but also to meet the requirements of well-informed and demanding consumers of dairy products. Irrespective of economic aspects, mastitis and its associated implications have detrimental effects on animal welfare [25].…”

Section: Several Studies Have Reported Correlations Between Differentmentioning

confidence: 99%

In vivo model to study the impact of genetic variation on clinical outcome of mastitis in dairy uniparous cows

Rohmeier

Petzl

Koy

et al. 2020

Preprint

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Background: In dairy herds, mastitis causes detrimental economic losses. Genetic selection offers a sustainable tool to select animals with reduced susceptibility towards postpartum diseases. Studying underlying mechanisms is important to assess the physiological processes that cause differences between selected haplotypes. Therefore, the objective of this study was to establish an in vivo infection model to study the impact of selecting for alternative paternal haplotypes in a particular genomic region on cattle chromosome 18 for mastitis susceptibility under defined conditions in dairy uniparous cows. Results: At the start of pathogen challenge, no significant differences between the favorable (Q) and unfavorable (q) haplotypes were detected. Intramammary infection (IMI) with Staphylococcus aureus 1027 (S. aureus, n = 24, 96 h) or Escherichia coli 1303 (E. coli, n = 12, 24 h) was successfully induced in all uniparous cows. This finding was confirmed by clinical signs of mastitis and repeated recovery of the respective pathogen from milk samples of challenged quarters in each animal. After S. aureus challenge, Q-uniparous cows showed lower somatic cell counts 24 h and 36 h after challenge (P < 0.05), lower bacterial shedding in milk 12 h after challenge (P < 0.01) and a minor decrease in total milk yield 12 h and 24 h after challenge (P < 0.01) compared to q-uniparous cows. Conclusion: An in vivo infection model to study the impact of genetic selection for mastitis susceptibility under defined conditions in dairy uniparous cows was successfully established and revealed significant differences between the two genetically selected haplotype groups. This result might explain their differences in susceptibility towards IMI. These clinical findings form the basis for further in-depth molecular analysis to clarify the underlying genetic mechanisms for mastitis resistance.

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Section: Several Studies Have Reported Correlations Between Differentmentioning

confidence: 99%

In vivo model to study the impact of genetic variation on clinical outcome of mastitis in dairy uniparous cows

Rohmeier

Petzl

Koy

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

In vivo model to study the impact of genetic variation on clinical outcome of mastitis in uniparous dairy cows

et al. 2020

View full text Add to dashboard Cite

Background: In dairy herds, mastitis causes detrimental economic losses. Genetic selection offers a sustainable tool to select animals with reduced susceptibility towards postpartum diseases. Studying underlying mechanisms is important to assess the physiological processes that cause differences between selected haplotypes. Therefore, the objective of this study was to establish an in vivo infection model to study the impact of selecting for alternative paternal haplotypes in a particular genomic region on cattle chromosome 18 for mastitis susceptibility under defined conditions in uniparous dairy cows. Results: At the start of pathogen challenge, no significant differences between the favorable (Q) and unfavorable (q) haplotypes were detected. Intramammary infection (IMI) with Staphylococcus aureus 1027 (S. aureus, n = 24, 96 h) or Escherichia coli 1303 (E. coli, n = 12, 24 h) was successfully induced in all uniparous cows. This finding was confirmed by clinical signs of mastitis and repeated recovery of the respective pathogen from milk samples of challenged quarters in each animal. After S. aureus challenge, Q-uniparous cows showed lower somatic cell counts 24 h and 36 h after challenge (P < 0.05), lower bacterial shedding in milk 12 h after challenge (P < 0.01) and a minor decrease in total milk yield 12 h and 24 h after challenge (P < 0.01) compared to q-uniparous cows. Conclusion: An in vivo infection model to study the impact of genetic selection for mastitis susceptibility under defined conditions in uniparous dairy cows was successfully established and revealed significant differences between the two genetically selected haplotype groups. This result might explain their differences in susceptibility towards IMI. These clinical findings form the basis for further in-depth molecular analysis to clarify the underlying genetic mechanisms for mastitis resistance.

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“…Conditions such as mastitis and lameness are common in dairy cattle with serious economic impacts [ 14 , 15 , 16 ]. These disorders result in behaviors associated with pain and discomfort, such as abnormal lying periods and reduced feed intake [ 17 , 18 ]. Previous studies have reported that behavior is the first thing to be affected by a disease state [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…In calves, changes in activity levels in association with disease state have been monitored [ 20 , 21 , 22 ]. Therefore, accurate real-time monitoring of behavior could be used as an early disease detection tool and subsequently reduce the time taken to treat sick animals [ 17 ]. Early diagnosis and treatment of disease could minimize economic losses that typically result from decreased productivity and high mortality rates [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Description of Behavioral Patterns Displayed by a Recently Weaned Cohort of Healthy Dairy Calves

Alawneh

Barreto

Bome

et al. 2020

Animals

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Animals display movement patterns that can be used as health indicators. The movement of dairy cattle can be characterized into three distinct cluster types. These are cluster type 1 (resting), cluster type 2 (traveling), and cluster type 3 (searching). This study aimed to analyze the movement patterns of healthy calves and assess the relationship between the variables that constitute the three cluster types. Eleven Holstein calves were fitted with GPS data loggers, which recorded their movement over a two week period during spring. The GPS data loggers captured longitude and latitude coordinates, distance, time and speed. It was found that the calves were most active during the afternoon and at night. Slight inconsistencies from previous studies were found in the cluster movements. Cluster type 2 (traveling) reported the fastest rate of movement, whereas cluster type 1 (resting) reported the slowest. These diverse movement patterns could be used to enhance the assessment of dairy animal health and welfare on farms.

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An Update on the Effect of Clinical Mastitis on the Welfare of Dairy Cows and Potential Therapies

Cited by 43 publications

References 47 publications

In vivo model to study the impact of genetic variation on clinical outcome of mastitis in dairy uniparous cows

In vivo model to study the impact of genetic variation on clinical outcome of mastitis in dairy uniparous cows

In vivo model to study the impact of genetic variation on clinical outcome of mastitis in uniparous dairy cows

Description of Behavioral Patterns Displayed by a Recently Weaned Cohort of Healthy Dairy Calves

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