An Update on the Cardiovascular Effects of Quercetin, a Plant Flavonoid

Islam, Mohammed A.; Schmidt, Robert W.; Gunaseelan, Simi; Sanchez, Anthony

doi:10.2174/157340131001140328115216

Cited by 14 publications

(10 citation statements)

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“…The experiment conducted by Mosawy et al (2013), found out that full inhibition of arachidonic acid induced platelet aggregation was achieved at 200 µM level of quercetin concentration. It was also proved that quercetin causes adenosine diphosphate (ADP) and epinephrine induced platelet aggregation (Islam et al, 2014). A similar activity was observed concerning glycoside of quercetin i.e.…”

Section: Anti-aggregation Activitysupporting

confidence: 56%

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Quercetin – a flavonoid with a high health-promoting potential

Kulczyński¹,

Gramza‐Michałowska²,

Sidor³

2016

Nauka Przyr. Technol.

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Summary.Flavonoids are an important group of bioactive compounds with a high antioxidant potential. Among them, one of the most common components is quercetin, belonging to the flavonols group. The main sources of quercetin are: capers, chokeberries, onions, chia seeds, honey and elderberries. This flavonoid shows a number of health-promoting properties, such as lowering blood sugar level, improving blood lipid profile, lowering blood pressure, and antimicrobial and antiplatelet activity.

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Section: Anti-aggregation Activitysupporting

confidence: 56%

“…According to 4 the literature data, quercetin makes 68-73% of all the flavonoids consumed by western societies (Islam et al, 2014). Those who eat a lot of vegetables and fruits abundant in flavonoids (apples, tomatoes, onions) may be delivering even 200-500 mg of the component to the organism per day (Russo et al, 2012).…”

Section: Food-origin Quercetin Sourcesmentioning

confidence: 99%

Quercetin – a flavonoid with a high health-promoting potential

Kulczyński¹,

Gramza‐Michałowska²,

Sidor³

2016

Nauka Przyr. Technol.

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“…The probable reason for the increased blood urea might be due to the high protein intake, particularly sulfur containing amino acids (Methionine and Cystine) that increase endogenous acid production, causing a parallel increase in ammonia excretion. 22 Findings of our study showed significant reduction in breathlessness, palpitation, chest pain, blood pressure, serum cholesterol, LDL, MDA concentration on 60 th day as compared to 0 day in test group. The pathogenesis of atherosclerosis involves two process viz oxidative stress and formation of atherosclerotic plaque.…”

Section: Safety Parameterssupporting

confidence: 50%

Protective Effect Of Aabresham (Bombyx Mori) Against Atherosclerosis

Parveen¹

2018

IJAHM

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“…The BP‐lowering effect of quercetin is more evident in subjects with certain comorbidities such as metabolic syndrome or in smokers . Different studies tried to establish a connection between the antihypertensive effect of quercetin and certain phenotypes such as the apolipoproteins (apo) E3 and E4, but so far results are conflicting …”

Section: Introductionmentioning

confidence: 99%

“…25 Different studies tried to establish a connection between the antihypertensive effect of quercetin and certain phenotypes such as the apolipoproteins (apo) E3 and E4, but so far results are conflicting. 26 However, evidence of the effects of quercetin on BP has not been conclusive. Therefore, we systematically reviewed all available randomized controlled trials (RCTs) investigating the impact of quercetin on BP.…”

mentioning

confidence: 99%

Effects of Quercetin on Blood Pressure: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Șerban

Sahebkar

Zanchetti

et al. 2016

JAHA

244

134

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BackgroundQuercetin, the most abundant dietary flavonol, has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. We assessed the impact of quercetin on BP through a systematic review and meta‐analysis of available randomized controlled trials.Methods and ResultsWe searched PUBMED, Cochrane Library, Scopus, and EMBASE up to January 31, 2015 to identify placebo‐controlled randomized controlled trials investigating the effect of quercetin on BP. Meta‐analysis was performed using either a fixed‐effects or random‐effect model according to I2 statistic. Effect size was expressed as weighted mean difference (WMD) and 95% CI. Overall, the impact of quercetin on BP was reported in 7 trials comprising 9 treatment arms (587 patients). The results of the meta‐analysis showed significant reductions both in systolic BP (WMD: −3.04 mm Hg, 95% CI: −5.75, −0.33, P=0.028) and diastolic BP (WMD: −2.63 mm Hg, 95% CI: −3.26, −2.01, P<0.001) following supplementation with quercetin. When the studies were categorized according to the quercetin dose, there was a significant systolic BP and diastolic BP‐reducing effect in randomized controlled trials with doses ≥500 mg/day (WMD: −4.45 mm Hg, 95% CI: −7.70, −1.21, P=0.007 and −2.98 mm Hg, 95% CI: −3.64, −2.31, P<0.001, respectively), and lack of a significant effect for doses <500 mg/day (WMD: −1.59 mm Hg, 95% CI: −4.44, 1.25, P=0.273 and −0.24 mm Hg, 95% CI: −2.00, 1.52, P=0.788, respectively), but indirect comparison tests failed to significant differences between doses.ConclusionsThe results of the meta‐analysis showed a statistically significant effect of quercetin supplementation in the reduction of BP, possibly limited to, or greater with dosages of >500 mg/day. Further studies are necessary to investigate the clinical relevance of these results and the possibility of quercetin application as an add‐on to antihypertensive therapy.

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An Update on the Cardiovascular Effects of Quercetin, a Plant Flavonoid

Cited by 14 publications

References 0 publications

Quercetin – a flavonoid with a high health-promoting potential

Quercetin – a flavonoid with a high health-promoting potential

Protective Effect Of Aabresham (Bombyx Mori) Against Atherosclerosis

Effects of Quercetin on Blood Pressure: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

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