An update on prevention of malaria in travelers

Higuita, Nelson Iván Agudelo; White, Bryan P.; Franco‐Paredes, Carlos; McGhee, Miranda

doi:10.1177/20499361211040690

Cited by 4 publications

(5 citation statements)

References 104 publications

(170 reference statements)

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“…Thus, JNJ-1802 has the potential to be effective in both prophylactic and therapeutic settings. Prophylaxis can be beneficial for travellers to, as well as for vulnerable populations living in, dengue-endemic regions 21 , as shown by the effective use of prophylactic drugs for the prevention of malaria 35 , 36 . A dengue antiviral drug administered as pre-exposure prophylaxis may have an effect across different levels, that is, individual and community.…”

Section: Discussionmentioning

confidence: 99%

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Goethals

Kaptein

Kesteleyn

et al. 2023

Nature

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Dengue is a major health threat and the number of symptomatic infections caused by the four dengue serotypes is estimated to be 96 million1 with annually around 10,000 deaths2. However, no antiviral drugs are available for the treatment or prophylaxis of dengue. We recently described the interaction between non-structural proteins NS3 and NS4B as a promising target for the development of pan-serotype dengue virus (DENV) inhibitors3. Here we present JNJ-1802—a highly potent DENV inhibitor that blocks the NS3–NS4B interaction within the viral replication complex. JNJ-1802 exerts picomolar to low nanomolar in vitro antiviral activity, a high barrier to resistance and potent in vivo efficacy in mice against infection with any of the four DENV serotypes. Finally, we demonstrate that the small-molecule inhibitor JNJ-1802 is highly effective against viral infection with DENV-1 or DENV-2 in non-human primates. JNJ-1802 has successfully completed a phase I first-in-human clinical study in healthy volunteers and was found to be safe and well tolerated4. These findings support the further clinical development of JNJ-1802, a first-in-class antiviral agent against dengue, which is now progressing in clinical studies for the prevention and treatment of dengue.

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Section: Discussionmentioning

confidence: 99%

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Goethals

Kaptein

Kesteleyn

et al. 2023

Nature

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“…They were required to continue taking 1 weekly dose during their stay and for four consecutive weeks after leaving. The recommended weekly dosage for adult patients is 310 mg of the active ingredient [ 62 ]. We believe that administering short-term low-dose antimalarial drugs does not result in the development of antibiotic resistance.…”

Section: Safety Of Hcqmentioning

confidence: 99%

Hydroxychloroquine in obstetrics: potential implications of the prophylactic use of hydroxychloroquine for placental insufficiency during pregnancy

Kim,

Sung,

Cha

et al. 2024

Obstet Gynecol Sci

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Proper placentation during early pregnancy is a key factor for maintaining a healthy pregnancy. Placental insufficiency leads to critical complications such as preeclampsia, fetal growth restriction, and fetal demise. These complications are often associated with pathological findings of restricted remodeling and obstructive lesions of the myometrial spiral arteries, which have high recurrence rates during subsequent pregnancies. Currently, there are no pharmacological interventions other than aspirin for the prevention of preeclampsia. Hydroxychloroquine (HCQ), a well-known antimalarial drug, reduces inflammatory and thrombotic changes in vessels. For decades, the use of HCQ for autoimmune diseases has resulted in the successful prevention of both arterial and venous thrombotic events and has been extended to the treatment of lupus and antiphospholipid antibody syndrome during pregnancy. HCQ reduces the risk of preeclampsia with lupus by up to 90%. Several recent studies have investigated whether HCQ improves pregnancy outcomes in women with a history of poor outcomes. In addition, in vitro and animal studies have demonstrated the beneficial effects of HCQ in improving endothelial dysfunction and alleviating hypertension and proteinuria. Therefore, we hypothesized that HCQ has the potential to attenuate the vascular inflammatory and thrombogenic pathways associated with placental insufficiency and conducted a multicenter clinical trial on the efficacy of combining aspirin with HCQ for pregnancies at high risk for preeclampsia in Korea. This study summarizes the potential effects of HCQ on pregnancies with placental insufficiency and the implications of HCQ treatment in the field of obstetrics.

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“…Preventive procedures in endemic countries pertain to both visitors and the indigenous people, especially in the areas of constant malaria transmission risk. Basic measures comprise clothes that cover most of the body, repellents, and mosquito bed nets, such as long-lasting insecticidal nets (LLINs) [ 42 ]. There is an array of commercially available repellents, including coils, candles and sprays.…”

Section: Treatment and Preventionmentioning

confidence: 99%

Malaria Detection Using Advanced Deep Learning Architecture

Siłka

Wieczorek

Siłka

et al. 2023

Sensors

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Malaria is a life-threatening disease caused by parasites that are transmitted to humans through the bites of infected mosquitoes. The early diagnosis and treatment of malaria are crucial for reducing morbidity and mortality rates, particularly in developing countries where the disease is prevalent. In this article, we present a novel convolutional neural network (CNN) architecture for detecting malaria from blood samples with a 99.68% accuracy. Our method outperforms the existing approaches in terms of both accuracy and speed, making it a promising tool for malaria diagnosis in resource-limited settings. The CNN was trained on a large dataset of blood smears and was able to accurately classify infected and uninfected samples with high sensitivity and specificity. Additionally, we present an analysis of model performance on different subtypes of malaria and discuss the implications of our findings for the use of deep learning in infectious disease diagnosis.

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An update on prevention of malaria in travelers

Cited by 4 publications

References 104 publications

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Hydroxychloroquine in obstetrics: potential implications of the prophylactic use of hydroxychloroquine for placental insufficiency during pregnancy

Malaria Detection Using Advanced Deep Learning Architecture

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