An update on possible pathogenic mechanisms of periodontal pathogens on renal dysfunction

Chopra, Aditi; Sivaraman, Karthik

doi:10.1080/1040841x.2018.1553847

Cited by 17 publications

(27 citation statements)

References 177 publications

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“…The first study that investigated association between periodontitis and CKD was conducted by Kshirsagar et al (2007), and concluded that a patient with severe periodontitis was twice as likely to develop CKD [16]. In a National Health and Nutrition Examination Research (NHASES III) study conducted in 2017 with 13,748 individuals with CKD, Chopra et al (2019) also concluded that propensity to have peridontitis was higher in this group [1].…”

Section: Discussionmentioning

confidence: 99%

“…Chronic kidney disease (CKD) consists of a progressive and irreversible change in renal structure, which causes reduction or filtering limitation and increases uremia levels, which is characterized by increased substances in blood [1][2][3]. This condition, due to high number of toxic substances in blood circulation, causes immunodeficiency and suppressed humoral response [2].…”

Section: Introductionmentioning

confidence: 99%

“…Periodontal disease has an infectious and inflammatory etiopathogenesis of tooth support tissues [7][8][9] and has risk factors in common with CKD, such as smoking, uncontrolled diabetes, age and obesity, which coincidentally together exacerbate renal inflammation [1].…”

Section: Introductionmentioning

confidence: 99%

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Quality of life and periodontal health of patients submitted to hemodialysis

Holanda

Castro

Moreira

et al. 2020

BJHR

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Objective: to evaluate quality of life for periodontal health in patients undergoing hemodialysis at Hospital Vida in Maceió, Alagoas, Brazil. Methods: After examination by Research Ethics Committee of Centro Universitário Tiradentes-AL, participants included through convenience sample method, found in hemodialysis at Hospital Vida. General health information, level of education, number of teeth, use of prostheses and periodontal clinical methods were collected through probing. To analyze impact of oral health on quality of life, the Oral Health Impact Profile (OHIP-14) questionnaire was used. Data were analyzed using arithmetic mean. The OHIP-14 answers received a score that were multiplied by specific weight of each question. The results were grouped and presented by descriptive analysis. Results: 126 participants with a mean age of 52.8 years were included. Among them, 78 (61.9%) men and 48 (38%) women. The mean number of teeth was 15.9 and, at periodontal probing, mean probing depth of 2.6 mm and clinical attachment level of 1.9 mm were observed. Final code OHIP-14 mean was 9.53. Conclusions: After results evaluation, it was possible to observe occurrence of periodontitis in participants, high rates of unsatisfactory dental prostheses, as well as low impact of quality of life in relation to number of teeth and school level.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quality of life and periodontal health of patients submitted to hemodialysis

Holanda

Castro

Moreira

et al. 2020

BJHR

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“…7 Centre for Chronic Disease, University of Queensland, Brisbane, QLD, Australia. 8 Westmead Centre for Medical Research, University of Sydney & Department of Renal Medicine, Westmead Hospital, Sydney, NSW, Australia. 9 Aboriginal Research Unit, South Australian Health & Medical Research Institute, Adelaide, SA, Australia.…”

Section: Acknowledgementsmentioning

confidence: 99%

“…Biological plausibility for considering periodontal disease as a CKD risk factor is derived from the potential role of the inflammatory response to periodontal disease in the chronic systemic inflammatory burden associated with CKD [7]. Specifically, the local tissue destructive immuno-inflammatory response to periodontal pathogens, their products and inflammatory cytokines are believed to contribute to the chronic systemic inflammatory burden [8].…”

Section: Introductionmentioning

confidence: 99%

Lessons learned from a periodontal intervention to reduce progression of chronic kidney disease among Aboriginal Australians

et al. 2020

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Objective Periodontal disease is associated with chronic kidney disease (CKD), with both conditions being highly prevalent among Australia’s Aboriginal population. This paper reflects on the lessons learned following implementation of a periodontal intervention in the Central Australian region of the Northern Territory among Aboriginal adults with CKD. Results Between Oct 2016 and May 2019, research staff recruited 102 eligible participants. This was far below the anticipated recruitment rate. The challenges faced, and lessons learned, were conceptualised into five specific domains. These included: (1) insufficient engagement with the Aboriginal community and Aboriginal community-controlled organisations; (2) an under-appreciation of the existing and competing patient commitments with respect to general health and wellbeing, and medical treatment to enable all study commitments; (3) most study staff employed from outside the region; (4) potential participants not having the required number of teeth; (5) invasive intervention that involved travel to, and time at, a dental clinic. A more feasible research model, which addresses the divergent needs of participants, communities and service partners is required. This type of approach, with sufficient time and resourcing to ensure ongoing engagement, partnership and collaboration in co-design throughout the conduct of research, challenges current models of competitive, national research funding.

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Periodontitis aggravates kidney injury by upregulating STAT1 expression in a mouse model of hypertension

et al. 2021

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Periodontitis is an autoimmune disease of periodontal tissues initiated by plaque. It is known that there is a close connection between periodontitis and CKD with hypertension, but the underlying mechanisms are unknown. STAT1 has been reported to play a regulatory role in hypertension and chronic kidney disease (CKD). Here, we investigated whether STAT1 regulates periodontitis‐mediated aggravation of kidney injury with accompanying hypertension. A hypertensive renal injury mouse model was established with Nos3 knockout mice, and a periodontitis model was established by implantation with the oral bacteria Porphyromonas gingivalis. The mice were intraperitoneally injected with a STAT1 inhibitor. Periodontitis aggravated kidney injury in hypertensive mice, and upregulation of STAT1 was observed when both periodontitis and hypertension were present; furthermore, STAT1 inhibitor moderated this effect. Moreover, we observed that periodontitis promoted the upregulation of inflammatory and fibrosis gene expression in the kidneys of hypertensive mice. In addition, STAT1 inhibition decreased the expression of pro‐inflammatory and pro‐fibrotic cytokines in the kidney lesion area. Periodontitis augmented the expression of inflammatory and fibrosis genes by upregulating the expression of STAT1, thereby aggravating kidney injury in the hypertensive mouse model.

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An update on possible pathogenic mechanisms of periodontal pathogens on renal dysfunction

Cited by 17 publications

References 177 publications

Quality of life and periodontal health of patients submitted to hemodialysis

Quality of life and periodontal health of patients submitted to hemodialysis

Lessons learned from a periodontal intervention to reduce progression of chronic kidney disease among Aboriginal Australians

Periodontitis aggravates kidney injury by upregulating STAT1 expression in a mouse model of hypertension

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