An update on pathogenesis and management of tuberculosis with special reference to drug resistance

Bhunia, Sujay Kumar; Sarkar, Mrinmoy; Banerjee, Asesh; Giri, Biplab

doi:10.1016/s2222-1808(15)60912-4

Cited by 10 publications

(10 citation statements)

References 104 publications

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“…The mechanism of MDR-TB occurrence is associated to drug failure in affecting the germs, or germs that do not absorb OAT. Bhunia et al (2015) explains that the behavioral changing from sensitive to resistant due to lack of treatment usually occurs within a few weeks after the start of treatment with different time of the occurrence of resistance in each individual. Patients' obedience in the treatment greatly affects the success of treatment.…”

Section: The Association Between Drug Taking Adherence and Mdr-tbmentioning

confidence: 99%

Biopsychosocial Determinants of Multi Drug Resistant Tuberculosis in Surakarta

Alfiyani

Rahardjo

Murti

2017

J EPIDEMIOL PUBLIC HEALTH

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Background: Tuberculosis is an infectious disease that poses serious threat to population health worldwide. Tuberculosis control enterprise becomes more complicated due to increasing number of Multi Drug Resistant Tuberkulosis (MDR-TB) cases. Globally there are approximately 580,000 cases of MDR-TB, with only 125,000 cases (20%) resolved. Indonesia ranks tenth in the world by the number of MDR-TB cases after Angola,

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Section: The Association Between Drug Taking Adherence and Mdr-tbmentioning

confidence: 99%

Biopsychosocial Determinants of Multi Drug Resistant Tuberculosis in Surakarta

Alfiyani

Rahardjo

Murti

2017

J EPIDEMIOL PUBLIC HEALTH

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“…Only 52% of MDR-TB patients were being treated successfully, mostly because of a high rate of mortality and patients lost to follow up (WHO, 2016). Mutations causing bacteria to be resistant to antibiotics are always correlated with a fitness cost to the bacteria (Cohen et al, 2003;Bhunia et al, 2015;Melnyk et al, 2015). An earlier study revealed that resistance being caused by mutations could impair the fitness of bacteria because mutations targeted genes encoding important cellular functions (Melnyk et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Severity of Tb Classified by Modified Bandim Tb Scoring Associates With the Specific Sequence of Esxa Genes in MDR-Tb Patients

Dewi

Mertaniasih

Soedarsono

2020

AJID

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Background: The severity of pulmonary TB and detection of multidrug-resistant (MDR-TB) TB strains as potential causative agents could be crucial for the determination of treatment success. This study aimed to analyze the association between the specific sequences of the full esxA gene from MDR-TB sputum isolates and the severity class of MDR-TB patients. Material and Methods: A total of 98 sputum samples that were suspected to be MDR-TB were collected from Dr. Soetomo, Surabaya, Indonesia, from September to December 2016. A total of 24 isolates from the 98 patients were confirmed to have positive MDR-TB based on the GeneXpert test. MDR-TB isolates were tested using PCR targeting 580 bp encompassing the full esxA gene, and the resulting amplicon was sequenced. The severity class of the pulmonary TB patients was assessed using modified Bandim TB scoring. Results: The patient severity classification resulted in a moderate and severe degree of TB in 38% and a mild degree of TB in 63% of patients. Visualization of the PCR results showed that all MDR-TB samples were positive for the 580 bp band, and the sequence results showed 100% homology with that of the virulent wild-type M. tuberculosis H37Rv (NC_000962.3). Conclusions: In the current study, an association between the characteristics of the full esxA gene and the severity class of MDR-TB patients is yet to be found. However, the homologous sequence of all samples, associated with various degrees of disease severity, possess 100% identity with that of wild-type M. tuberculosis H37Rv.

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“…Tuberculosis (TB) is caused by Mycobacterium tuberculosis, a serious human pathogen that infects about one-third of the human's population globally [1]. It has emerged as a major health issue worldwide and considered the second most fatal contagious disease [2].…”

Section: Introductionmentioning

confidence: 99%

“…For the diagnosis of TB, different conventional methods like drug sensitivity can be used. However modern detection methods include polymerase chain reaction, restriction fragment length polymorphism (RFLP), and chemotherapy of drug resistance or even surgery in severe cases [2].…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis: a short glimpse

Shad¹,

Shad²

2019

Int Med

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Mycobacterium tuberculosis is an acid-fast bacterium, that cause the disease of significant burden worldwide i.e. tuberculosis (TB). Because of its airborne transmission, it remains a milestone and a very strong hurdle to limit its spread. More significantly, its targeting area mostly is alveolar macrophages present in the lungs, in which it can reside as a silent killer. This mini review aims to highlight the fundamentals of Mycobacterium tuberculosis, its disease-causing pattern, and treatment options that have been developed to tackle the disease. TB has been categorized into re-emerging disease in many parts of the world, so there is a need to look on it. Further prevention and controlling strategies also discussed in last to highlight the importance in which sense the TB prevalence could potentially be reduced.

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An update on pathogenesis and management of tuberculosis with special reference to drug resistance

Cited by 10 publications

References 104 publications

Biopsychosocial Determinants of Multi Drug Resistant Tuberculosis in Surakarta

Biopsychosocial Determinants of Multi Drug Resistant Tuberculosis in Surakarta

Severity of Tb Classified by Modified Bandim Tb Scoring Associates With the Specific Sequence of Esxa Genes in MDR-Tb Patients

Tuberculosis: a short glimpse

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