An update on opsoclonus

Wong, Agnes M. F.

doi:10.1097/wco.0b013e3280126b51

Cited by 139 publications

(138 citation statements)

References 105 publications

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“…Tais achados podem ser avaliados por escalas de graduação específicas para essa enfermidade (7) . Pode-se evidenciar também a regressão do desenvolvimento neuromotor em grande número de casos durante o seguimento, resultando em sequelas neurológicas variáveis (5,8,9) . Essa síndrome é mais frequentemente registrada em adultos do que em crianças (9) .…”

Section: Discussionunclassified

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Síndrome de Kinsbourne manifestando-se com quadro de encefalite pós-viral

Andrade

Troster

Cypel

2011

Rev. paul. pediatr.

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OBJETIVO: Descrever um caso de síndrome de Kinsbourne manifestando-se com quadro de encefalite pós-viral e rever a da literatura. DESCRIÇÃO DO CASO: Criança do sexo feminino, dois anos e seis meses, encaminhada de outro serviço com história de ataxia, irritabilidade e dificuldades articulatórias na fala após episódio prodrômico de febre, lesões de pele e mucosa. Com hipótese de encefalite pós-viral, a avaliação clínica evidenciou quadro de síndrome opsoclônus-mioclonia-ataxia ou síndrome de Kinsbourne. Foi afastada a associação de neuroblastoma oculto e iniciada terapêutica com corticosteroide. Durante internação e acompanhamento ambulatorial, houve regressão progressiva e normalização do quadro clínico e neurológico inicial. COMENTÁRIOS: Apesar de se tratar de uma doença rara, o diagnóstico de síndrome de Kinsbourne deve ser reconhecido pelos pediatras e intensivistas, com objetivo de instituir tratamento específico precoce, embora com resultados variáveis, sendo fundamental a exclusão de neuroblastoma oculto.

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Section: Discussionunclassified

“…O reconhecimento dessa doença é de suma importância, em vista da conhecida associação com neuroblastoma oculto, suas implicações prognósticas e devido a uma proporção considerável de pacientes que respondem clinicamente por meio de tratamento imunossupressor, como esteroides e imunoglobulina, entre outras terapias imunomodulatórias (5,6) .…”

Section: Introductionunclassified

Síndrome de Kinsbourne manifestando-se com quadro de encefalite pós-viral

Andrade

Troster

Cypel

2011

Rev. paul. pediatr.

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“…The majority of patients with opsoclonus, for example, are seronegative for autoantibodies. 10 It is important for the clinician to differentiate ocular flutter from other saccadic motility disorders. Microsaccadic oscillations and square wave jerks can be distinguished from ocular flutter by the presence of an intersaccadic interval.…”

Section: Discussionmentioning

confidence: 99%

Ocular flutter as the presenting sign of lung adenocarcinoma

Kruger¹,

Yonekawa²,

Skidd³

et al. 2014

Digit J Ophthalmol

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SummaryOcular flutter is a rare ophthalmic finding that could represent paraneoplastic phenomena. In adults it is most commonly associated with small cell lung cancer (SCLC). Most patients also present with other neurological defects. We report the case of a 75-year-old woman who presented with isolated ocular flutter. The ensuing workup was significant for an early lung adenocarcinoma that would not have been biopsied otherwise due to its small size. To our knowledge, this is the first reported case of isolated ocular flutter as the presenting symptom of non-SCLC.

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“…Mild pleocytosis may be observed in BOS. Anti-Ri antibody accompanied with breast and gynecologic cancers was detected in adult cases, while no antibody was detected in pediatric group (Wong, 2007). It is one of the PNS showing the best response to treatment.…”

Section: Opsoclonus-myoclonusmentioning

confidence: 99%

Paraneoplastic neurologic disorders

Şen¹,

Terzı²

2013

jecm

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IntroductionParaneoplastic neurologic syndromes (PNS) are manifestations of cancers which are located outside the central nervous system. They appear before the diagnosis of cancer in most of patients. Identification of these disorders is very important as it leads to diagnosis and treatment of cancer subsequently. PNS are divided into two groups as classical and non-classical. Classical PNS are associated with cancer more than non-classical PNS. Non-classical PNS are rather observed in cases without cancer. PNS can also be divided into two groups as per the involvement of the central and peripheral nervous system (Table 1) (Bradley, 2008;Tüzün, 2010). EpidemiologyPNS are rare disorders in cancer patients. Frequency in all cancer patients is 0.01% (Darnell and Posner, 2003). Women/ men ratio is approximately 3:1. It is usually observed beyond mid-life. They show a closer association with some kinds of cancer. They have a more frequent association especially with hematologic diseases such as small cell lung cancer (SCLC), thymoma, and monoclonal gammopathy. Other can-cer types associated with PNS include breast, gynecological cancers such as ovarian and Hodgkin's, non-Hodgkin's lymphoma, testicular cancer and neuroblastoma (Toothaker and Rubin, 2009). Furthermore, development of PNS is possible in almost all neoplasms (Bataller and Dalmau, 2003). PathogenesisA widely accepted opinion is that these disorders occur due to stimulation of immune response by some proteins which are formed by a tumor, against both the tumor and the nervous system (Tüzün, 2010). Cytotoxic T-cell responses have a very important role in pathogenesis of PNS (Bradley, 2008). T-cells are responsible for both of the antibody-mediated processes (Albert et al., 1998). Lymphocytic pleocytosis and oligoclonal band positivity may be observed in BOS analysis (Armstrong et al., 2005).PNS are formed by antibodies developed against the intracellular antigen or neuronal surface antigen. In limbic encephalitis, there are antibodies for both regions. Anti Hu, anti Yo, anti Ri, anti Ma2, Cv2/CRMP5 are antibodies associated with intracellular antigen, whereas the VGKC complex

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An update on opsoclonus

Abstract: There is increasing recognition that both humoral and cell mediated immune mechanisms are involved in the pathogenesis of opsoclonus. Further studies are needed to further elucidate its immunopathogenesis and pathophysiology in order to develop novel and efficacious therapy.

Cited by 139 publications

References 105 publications

Síndrome de Kinsbourne manifestando-se com quadro de encefalite pós-viral

Síndrome de Kinsbourne manifestando-se com quadro de encefalite pós-viral

Ocular flutter as the presenting sign of lung adenocarcinoma

Paraneoplastic neurologic disorders

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