An update on minor salivary gland secretions

Eliasson, Lars; Carlén, Anette

doi:10.1111/j.1600-0722.2010.00766.x

Cited by 82 publications

(51 citation statements)

References 95 publications

(204 reference statements)

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“…They secrete glycoproteins (mucins) that cover and protect the underlying mucosa (MUC5B and MUC7). The larger salivary mucin MUC5B, present in (sero)mucous secretions including submandibular gland (SMG) saliva, is thought to be related to the perception of dry mouth by retaining moisture in the mucosa [7,8]. …”

Section: Resultsmentioning

confidence: 99%

MUC5B levels in submandibular gland saliva of patients treated with radiotherapy for head-and-neck cancer: A pilot study

et al. 2012

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BackgroundThe salivary mucin MUC5B, present in (sero)mucous secretions including submandibular gland (SMG) saliva, plays an important role in the lubrication of the oral mucosa and is thought to be related to the feeling of dry mouth. We investigated if MUC5B levels in SMG saliva could distinguish between the presence or absence of severe dry mouth complaints 12 months after radiotherapy (RT) for head-and-neck cancer (HNC).FindingsTwenty-nine HNC patients with a residual stimulated SMG secretion rate of ≥0.2 ml/10 min at 12 months after RT were analyzed. MUC5B (in U; normalized to 1) and total protein levels (mg/ml) were measured in SMG saliva at baseline and 12 months after RT using ELISA and BCA protein assay, respectively. Overall, median MUC5B levels decreased after RT from 0.12 to 0.03 U (p = 0.47). Patients were dichotomized into none/mild xerostomia (n = 12) and severe xerostomia (n = 17) based on a questionnaire completed at 12 months. SMG and whole saliva flow rates decreased after RT but were comparable in both groups. The median MUC5B level was higher in patients with no or mild xerostomia compared to patients with severe xerostomia (0.14 vs 0.01 U, p = 0.22). Half of the patients with severe xerostomia had no detectable MUC5B at 12 months after RT. No differences in total protein levels were observed.ConclusionsQualitative saliva parameters like MUC5B need further investigation in RT-induced xerostomia. This pilot study showed a trend towards lower MUC5B levels in the SMG saliva of patients with severe xerostomia 12 months after RT for HNC.

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Section: Resultsmentioning

confidence: 99%

MUC5B levels in submandibular gland saliva of patients treated with radiotherapy for head-and-neck cancer: A pilot study

et al. 2012

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“…The width of the drop less than 1mm is considered to show hipofunction. This test is easy to perform, but still needs more investigation to be included in SS classification criteria instead of lower lip biopsy [29]. …”

Section: Methodsmentioning

confidence: 99%

Diagnostic Approaches to Sjögren’s Syndrome: a Literature Review and Own Clinical Experience

Gomes¹,

Juodžbalys²,

Fernandes³

et al. 2012

JOMR

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ObjectivesThe purpose of present paper is to critically address the recent advances on diagnostic procedures of Sjögren's syndrome, taking into account the attained local and systemic features of the disease.Material and MethodsA comprehensive review of the available literature regarding to the diagnostic approaches to Sjögren's syndrome was conducted. Eligible studies were identified by searching the electronic literature PubMed, Medline, Embase, and ScienceDirect databases for relevant reports (last search update January 2012) combining the MESH heading term "Sjögren's syndrome", with the words "diagnosis, diagnostic procedures, salivary gland function, ocular tests, histopathology, salivary gland imaging, serology". The authors checked the references of the selected articles to identify additional eligible publications and contacted the authors, if necessary.ResultsPresented article addresses the established diagnostic criteria for Sjögren's syndrome and critically evaluates the most commonly used diagnostic procedures, presenting data from author's own clinical experience. Diagnostic criteria for Sjögren's syndrome are required both by healthcare professionals and patients, namely in order to provide a rational basis for the assessment of the symptoms, establish an individual disease prognosis, and orientate the therapeutic intervention.ConclusionsSjögren's syndrome is quite a common autoimmune disease of which the diagnosis and treatment are not easily established. Due to its systemic involvement, it can exhibit a wide range of clinical manifestations that contribute to confusion and delay in diagnosis. The use of proper diagnostic modalities will help to reduce the time to diagnosis and preserve the health and quality of life of patients with Sjögren's syndrome.

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“…Furthermore, the IgA concentrations agree well with those in other reports. 23 Nevertheless, the content of IgA has been shown to be correlated to oral health, both regarding …”

Section: Discussionmentioning

confidence: 99%

Tramadol-induced oral dryness and pilocarpine treatment: Effects on total protein and IgA

Looström

Åkerman

Ericson

et al. 2011

Archives of Oral Biology

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An update on minor salivary gland secretions

Cited by 82 publications

References 95 publications

MUC5B levels in submandibular gland saliva of patients treated with radiotherapy for head-and-neck cancer: A pilot study

MUC5B levels in submandibular gland saliva of patients treated with radiotherapy for head-and-neck cancer: A pilot study

Diagnostic Approaches to Sjögren’s Syndrome: a Literature Review and Own Clinical Experience

Tramadol-induced oral dryness and pilocarpine treatment: Effects on total protein and IgA

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