An update on epigenetic regulation in autoimmune diseases

Mei, Xiaole; Zhang, Bo; Zhao, Ming; Lu, Qianjin

doi:10.1016/j.jtauto.2022.100176

Cited by 9 publications

(9 citation statements)

References 161 publications

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“…Epigenetics and toxicogenetics (or toxicogenomics) are rapidly growing, overlapping fields [ 61 ]. Both fields have established the role of an individual’s personal environment in altering genes involved in a wide variety of medical conditions [ 62 , 63 ]. Substantial epidemiological literature links toxic exposures and genetics to autism [ 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children

Palmer,

Kattari,

Rincon

et al. 2024

JoX

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Background: We sought to replicate our 2015 findings linking chemical intolerance in parents with the risk of their children developing autism and/or ADHD. Drawing upon our 2021 discovery of a strong association between chemical intolerance and mast cells, we propose an explanation for this link. Methods: In a population-based survey of U.S. adults, we used the internationally validated Quick Environmental Exposure and Sensitivity Inventory (QEESI) to assess symptom severity and chemical intolerance. Parents were asked how many of their biological children had been diagnosed with autism and/or ADHD. Results: Parents with chemical intolerance scores in the top versus bottom tenth percentile had 5.7 times the risk of reporting a child with autism and 2.1 times for ADHD. Conclusions: High chemical intolerance scores among parents of children with autism, coupled with our 2021 discovery of mast cell activation as a plausible biomechanism for chemical intolerance, suggest that (1) the QEESI can identify individuals at increased risk, (2) environmental counseling may reduce personal exposures and risk, and (3) the global rise in autism and ADHD may be due to fossil-fuel-derived and biogenic toxicants epigenetically “turning on” or “turning off” critical mast cell genes that can be transmitted transgenerationally. It is important to note that this study was observational in nature; as such, further research is needed using controlled trials to confirm causality and explore the proposed mechanism.

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Section: Discussionmentioning

confidence: 99%

Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children

Palmer,

Kattari,

Rincon

et al. 2024

JoX

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“…Recently discovered non-coding RNAs, including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are also implicated in the etiology of autoimmune diseases. [ 41 ] Differential DNA methylation levels of specific genes related to inflammation, joint destruction, and immune regulation have been observed in RA patients’ joint tissues. [ 42 , 43 ] Furthermore, several validated lncRNAs, such as HOTAIR, GAS5, and HIX003209, have shown potential as novel biomarkers for diagnosis and treatment in RA [ 44 ] ; CREMα: CREMα is a transcription factor involved in the regulation of immune cell development, function, and stability.…”

Section: Discussionmentioning

confidence: 99%

Global research hotspots and frontier trends of epigenetic modifications in autoimmune diseases: A bibliometric analysis from 2012 to 2022

Gao,

Huang,

Wang

et al. 2023

Medicine

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Background: Recent studies have shown substantial progress in understanding the association between epigenetics and autoimmune diseases. However, there is a lack of comprehensive bibliometric analysis in this research area. This article aims to present the current status and hot topics of epigenetic research in autoimmune diseases (ADs) from a bibliometric perspective, as well as explore the frontier hotspots and trends in epigenetic studies related to ADs. Methods: This study collected 1870 epigenetic records related to autoimmune diseases from the web of science core collection database, spanning from 2012 to 2022. Analysis of regions, institutions, journals, authors, and keywords was conducted using CiteSpace, VOSviewer, and the R package “bibliometrix” to predict the latest trends in epigenetic research relevant to autoimmune diseases. Results: The number of epigenetic publications related to autoimmune diseases has been increasing annually. The United States has played a major role in this field, contributing over 45.9% of publications and leading in terms of publication volume and citation counts. Central South University emerged as the most active institution, contributing the highest number of publications. Frontiers in Immunology is the most popular journal in this field, publishing the most articles, while the Journal of Autoimmunity is the most co-cited journal. Lu QJ is the most prolific author, and Zhao M is the most frequently co-cited author. “Immunology” serves as a broad representative of epigenetic research in ADs. Hot topics in the field of epigenetic modifications associated with autoimmune diseases include “regulatory T cells (Treg),” “rheumatoid arthritis,” “epigenetic regulation,” “cAMPresponsive element modulator alpha,” “cell-specific enhancer,” “genetic susceptibility,” and “systemic lupus erythematosus.” Furthermore, the study discusses the frontiers and existing issues of epigenetic modifications in the development of autoimmune diseases. Conclusions: This study provides a comprehensive overview of the knowledge structure and developmental trends in epigenetic research related to autoimmune diseases over the past 11 years.

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“…rheumatoid arthritis [57] IFI44L −4.42 (0.0294) interferon-induced protein 44-like primary Sjogren's syndrome [39], systemic lupus erythematosus [58], rheumatoid arthritis [59], (ANCA)-Associated Vasculitis (AAV) [42], mixed connective tissue disease [52], systemic sclerosis [60]…”

Section: Gene Expression Analysis In T Reg Cellsmentioning

confidence: 99%

Gene Signature of Regulatory T Cells Isolated from Children with Selective IgA Deficiency and Common Variable Immunodeficiency

Rutkowska-Zapała,

Grabowska-Gurgul,

Lenart

et al. 2024

Cells

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Selective IgA deficiency (SIgAD) is the most common form and common variable immunodeficiency (CVID) is the most symptomatic form of predominant antibody deficiency. Despite differences in the clinical picture, a similar genetic background is suggested. A common feature of both disorders is the occurrence of autoimmune conditions. Regulatory T cells (Tregs) are the major immune cell type that maintains autoimmune tolerance. As the different types of abnormalities of Treg cells have been associated with autoimmune disorders in primary immunodeficiency (PID) patients, in our study we aimed to analyze the gene expression profiles of Treg cells in CVID and SIgAD patients compared to age-matched healthy controls. The transcriptome-wide gene profiling was performed by microarray technology. As a result, we analyzed and visualized gene expression patterns of isolated population of Treg cells. We showed the differences at the gene level between patients with and without autoimmunizations. Our findings suggest that the gene signatures of Treg cells isolated from SIgAD and CVID patients differ from age-matched healthy controls and from each other, presenting transcriptional profiles enriched in innate immune or Th response, respectively. The occurrence of autoimmunity in both types of PID is associated with down-regulation of class I IFNs signaling pathways. In summary, our findings improve our understanding of Treg dysfunctions in patients with common PIDs and associated autoimmunity.

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An update on epigenetic regulation in autoimmune diseases

Cited by 9 publications

References 161 publications

Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children

Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children

Global research hotspots and frontier trends of epigenetic modifications in autoimmune diseases: A bibliometric analysis from 2012 to 2022

Gene Signature of Regulatory T Cells Isolated from Children with Selective IgA Deficiency and Common Variable Immunodeficiency

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