An update on cardiovascular effects of obstructive sleep apnoea syndrome

Uyar, Meral; Davutoğlu, Vedat

doi:10.1136/postgradmedj-2016-134093

Cited by 16 publications

(9 citation statements)

References 72 publications

(43 reference statements)

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“…(Obstructive) sleep apnea syndrome ((O)SAS) is common with a prevalence of 44-87.5% in active and 35-58% in controlled acromegaly [ 98 , 99 ]. OSAS is associated with ED, hypertension, systemic inflammation, and dysglycemia; all factors associated with an increased risk of CVD [ 100 ]. In general, acromegaly treatment had a positive effect on OSAS, but did not always result in cure [ 101 , 102 ].…”

Section: Cvd Risk Factors In Patients With Acromegalymentioning

confidence: 99%

Acromegaly, inflammation and cardiovascular disease: a review

Wolters¹,

Netea

Riksen³

et al. 2020

Rev Endocr Metab Disord

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Acromegaly is characterized by Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) excess. Uncontrolled acromegaly is associated with a strongly increased risk of cardiovascular disease (CVD), and numerous cardiovascular risk factors remain present after remission. GH and IGF-1 have numerous effects on the immune and cardiovascular system. Since endothelial damage and systemic inflammation are strongly linked to the development of CVD, and have been suggested to be present in both controlled as uncontrolled acromegaly, they may explain the presence of both micro- and macrovascular dysfunction in these patients. In addition, these changes seem to be only partially reversible after remission, as illustrated by the often reported presence of endothelial dysfunction and microvascular damage in controlled acromegaly. Previous studies suggest that insulin resistance, oxidative stress, and endothelial dysfunction are involved in the development of CVD in acromegaly. Not surprisingly, these processes are associated with systemic inflammation and respond to GH/IGF-1 normalizing treatment.

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Section: Cvd Risk Factors In Patients With Acromegalymentioning

confidence: 99%

Acromegaly, inflammation and cardiovascular disease: a review

Wolters¹,

Netea

Riksen³

et al. 2020

Rev Endocr Metab Disord

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“…Sleepiness may be a marker of proinflammatory cytokine activity that mediates cardiometabolic disease in the setting of OSA. [46][47][48] Amassing evidence suggests a possible differential association between sex and OSA-associated inflammatory burden. [49][50][51][52] Sleepiness may also be important in determining response to OSA therapy and adherence.…”

Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnea, Sleepiness, and Glycemic Control in Type 2 Diabetes

Aurora

Punjabi

2019

Journal of Clinical Sleep Medicine

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Study Objectives: Self-reported sleepiness is common in patients with obstructive sleep apnea (OSA) and is being increasingly recognized as an effect modifier of the association between OSA and cardiovascular outcomes. However, data on whether sleepiness modifies the association between OSA and glycemic outcomes are lacking. The current study sought to characterize the association between glycemic control and sleepiness in people with OSA and type 2 diabetes. Methods: Adults with non-insulin requiring type 2 diabetes and undiagnosed moderate to severe OSA were recruited from the community. Demographic data, Epworth Sleepiness Scale (ESS), hemoglobin A1c (HbA1c), as well a type III home sleep test were obtained. The association between self-reported sleepiness and glycemic control was examined using quantile regression. Results: The study cohort included 311 participants with 56% of the sample being men. Stratified analyses by sex demonstrated that self-reported sleepiness was associated with a higher HbA1c level, but this association was present only in men with a body mass index (BMI) < 35 kg/m 2. Mean HbA1c levels were higher by 0.57% (95% confidence interval: 0.11, 1.02) in men with an ESS ≥ 11 compared to men with an ESS < 11. No such association was observed in men with a BMI ≥ 35 kg/m 2 or in women of any BMI category. Conclusions: The association between self-reported sleepiness and glycemic control in people with type 2 diabetes and moderate to severe OSA varies a function of BMI and sex. The noted differences in association should be considered when assessing possible treatment effects of therapy for OSA on metabolic outcomes.

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“…A Saos é uma desordem caracterizada pela obstrução parcial ou total das vias aéreas pelos tecidos moles que constituem a faringe, gerando transtornos funcionais sistêmicos e cognitivos 5,6 . Apesar de não ser uma ação consciente, a alteração do padrão normal do sono prejudica o nível profundo do sono, de modo que o paciente apresenta constantemente a sensação de "noite mal dormida", evidenciando sintomas de fatiga e sonolência diurna permanente 17 .…”

Section: Discussionunclassified

“…A Academia Americana de Medicina do Sono define Saos como uma doença que se caracteriza por episódios repetitivos de obstrução total (apneia) ou parcial (hipopneia) das vias aéreas superiores durante o sono 4 . Epidemiologicamente, está associada à má qualidade de vida e pode levar a um maior risco de acidentes domésticos e veiculares, depressão, ansiedade, perda de memória e doenças cardiovasculares 5,6 . A polissonografia é o padrão-ouro para avaliar a qualidade do sono do paciente e para diagnosticar a Saos 2,7 e os demais distúrbios do sono.…”

Section: Introductionunclassified

Cirurgia ortognática para tratamento da síndrome de apneia obstrutiva do sono: relato de caso

Panissa

Morawski

Tonietto

et al. 2018

Rev. da Fac. de Odontologia, UPF

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Objetivo: ilustrar, por meio de um caso clínico, os benefíciosdo tratamento da síndrome de apneia obstrutivade sono (Saos) por intermédio da cirurgia ortognáticabimaxilar, com o uso de biomateriais de reconstrução.Relato de caso: paciente encaminhado para avaliaçãode discrepância maxilomandibular em relação àbase do crânio e para avaliação de queixa de roncointenso durante a noite e intenso cansaço diurno. Apósavaliação e exames complementares, o paciente foidiagnosticado com apneia obstrutiva do sono; assim,foi realizada a cirurgia de avanço bimaxilar como terapêuticaresolutiva para o caso. Considerações finais:a Academia Americana de Medicina do Sono (AAMS)define Saos como uma doença que se caracteriza porepisódios repetitivos de obstrução total (apneia) ou parcial(hipopneia) das vias aéreas superiores durante osono. A cirurgia de avanço bimaxilar se apresenta comouma das melhores opções terapêuticas para os pacientescom essa síndrome. A cirurgia ortognática, incluindoseus diversos procedimentos, provoca importantesmudanças nas diferentes zonas das vias aéreas faríngeas.A cirurgia ortognática de avanço bimaxilar commentoplastia de avanço foi eficaz, em longo prazo, notratamento da Saos, e o uso simultâneo de biomateriaisde substituição óssea aumenta a estabilidade óssea primária,acelera o processo de reparo ósseo e diminui amorbidade pós-operatória. Palavras-chave: Apneia obstrutiva do sono. Avançomaxilar. Cirurgia ortognática.

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An update on cardiovascular effects of obstructive sleep apnoea syndrome

Cited by 16 publications

References 72 publications

Acromegaly, inflammation and cardiovascular disease: a review

Acromegaly, inflammation and cardiovascular disease: a review

Obstructive Sleep Apnea, Sleepiness, and Glycemic Control in Type 2 Diabetes

Cirurgia ortognática para tratamento da síndrome de apneia obstrutiva do sono: relato de caso

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