An Update on Cardiac Enzymes

Puleo, Peter; Roberts, Robert

doi:10.1016/s0733-8651(18)30504-6

Cited by 7 publications

(1 citation statement)

References 69 publications

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“…After experimentally induced myocardial infarction, as much as 75% of the CK activity may be released from injured myocardial tissue (for reviews, see Refs. 327,749,789,1120). Total plasma CK activity generally increases 4 -8 h after onset of chest pain, peaks within 12-14 h, and returns to normal within 72-96 h. Because CK may also be released from other tissues, while MB-CK is normally found in highest concentration in the heart, the latter was an accepted marker of AMI for many years.…”

Section: Implications For Human Pathological Conditions Involving Iscmentioning

confidence: 99%

Creatine and Creatinine Metabolism

Wyss

Kaddurah‐Daouk

2000

Physiological Reviews

2,352

2,103

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The goal of this review is to present a comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inherent implications for physiology and human pathology. Very recently, a series of new discoveries have been made that are bound to have distinguished implications for bioenergetics, physiology, human pathology, and clinical diagnosis and that suggest that deregulation of the creatine kinase (CK) system is associated with a variety of diseases. Disturbances of the CK system have been observed in muscle, brain, cardiac, and renal diseases as well as in cancer. On the other hand, Cr and Cr analogs such as cyclocreatine were found to have antitumor, antiviral, and antidiabetic effects and to protect tissues from hypoxic, ischemic, neurodegenerative, or muscle damage. Oral Cr ingestion is used in sports as an ergogenic aid, and some data suggest that Cr and creatinine may be precursors of food mutagens and uremic toxins. These findings are discussed in depth, the interrelationships are outlined, and all is put into a broader context to provide a more detailed understanding of the biological functions of Cr and of the CK system.

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Section: Implications For Human Pathological Conditions Involving Iscmentioning

confidence: 99%

Creatine and Creatinine Metabolism

Wyss

Kaddurah‐Daouk

2000

Physiological Reviews

2,352

2,103

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The Molecular Genetics of Sepsis: Clinical Epidemiology Considerations

Wax¹,

Angus²

2000

Yearbook of Intensive Care and Emergency Medicine

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Human heart-type cytoplasmic fatty acid-binding protein as an indicator of acute myocardial infarction

et al. 1995

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Human heart-type cytoplasmic fatty acid-binding protein (HH-FABPc) has been proposed as an early biochemical indicator of acute myocardial infarction (AMI). However, skeletal muscles also contain HH-FABPc identical to that found in the heart. Before HH-FABPc can be clinically employed as an indicator of AMI, its content in various tissues other than the heart must be known. Accordingly, we measured the HH-FABPc content of various human muscles and organs, using a sandwich enzyme-linked immunosorbent assay (ELISA) for HH-FABPc. HH-FABPc was abundant in the ventricles (0.46 mg/g wet weight and 1.5% of the cytoplasmic protein in the left ventricle), while the atria contained slightly less HH-FABPc (0.25 mg/g wet weight and 0.7% of the cytoplasmic protein in the left atrium). Of the skeletal muscles tested, the diaphragm contained about one-quarter of the HH-FABPc content of the heart, but other skeletal muscles contained very low levels of this protein. Other than the muscles, the kidneys contained less than one-tenth of the HH-FABPc in the heart, and negligible amounts were found in the liver and small intestine. The distribution of HH-FABPc in the heart and skeletal muscles was comparable to that of cardiac-specific creatine kinase (CK-MB) activity, and was inverse to the distribution of myoglobin. The plasma myoglobin/HH-FABPc ratio, determined in patients with AMI and those without AMI, closely reflected that in the heart and skeletal muscles. These findings indicate that HH-FABPc may be useful as a specific indicator of AMI, and the plasma myoglobin/HH-FABPc ratio could provide valuable information for the diagnosis of AMI.

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An Update on Cardiac Enzymes

Cited by 7 publications

References 69 publications

Creatine and Creatinine Metabolism

Creatine and Creatinine Metabolism

The Molecular Genetics of Sepsis: Clinical Epidemiology Considerations

Human heart-type cytoplasmic fatty acid-binding protein as an indicator of acute myocardial infarction

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