An update on applications of nanostructured drug delivery systems in cancer therapy: a review

Abstract

Cancer is a main public health problem that is known as a malignant tumor and out-of-control cell growth, with the potential to assault or spread to other parts of the body. Recently, remarkable efforts have been devoted to develop nanotechnology to improve the delivery of anticancer drug to tumor tissue as minimizing its distribution and toxicity in healthy tissue. Nanotechnology has been extensively used in the advance of new strategies for drug delivery and cancer therapy. Compared to customary drug delivery systems, nano-based drug delivery method has greater potential in different areas, like multiple targeting functionalization, in vivo imaging, extended circulation time, systemic control release, and combined drug delivery. Nanofibers are used for different medical applications such as drug delivery systems.

Nanodrugs used in cancer therapy

“…The release of the hydrophobic drugs with low solubility in aqueous environment can be further modified by addition of amphiphilic polymers such as PEG (ref. 60 ). Several studies have been published on the incorporation of anti-cancer drugs such as doxorubicin 61 , paclitaxel 62 , camptothecin 63 , or cisplatin 64 .…”

Nanomedicine approaches for sirolimus delivery: a review of pharmaceutical properties and preclinical studies

“…The emergence of pharmaceutical nanotechnology has great potential for sirolimus delivery due to small size, enhanced drug solubilization and dissolution rates, high efficiency in drug encapsulation and cellular uptake, controlled drug release, cargo protection from harsh environment, escape from reticuloendothelial system (RES), long circulation residence, targeted delivery to specific areas and modulation of drug pharmacokinetics and biodistribution [34][35][36]. This review focuses on recent studies that have investigated various nanostructured carriers such as liposomes, micelles, polymeric nanoparticles, nanocrystals, magnetic nanoparticles, albumin nanoparticles, solid dispersion nanoparticles and niosomes for sirolimus delivery (in organ transplantation, cancer, vascular restenosis, etc.)…”

Preparation and characterization of magnetic theranostic nanoparticles for curcumin delivery and evaluation as MRI contrast agent

“…Among the nanocarriers which applied in cancer treatment, iron oxide magnetic nanoparticles have concerned extensive attention, especially for cancer study . Inopportunely, naked iron oxide magnetic nanoparticles demonstrate somewhat accumulation and aggregation during usage which is regularly inevitable .…”