An Update on Antitumor Activity of Naturally Occurring Chalcones

Zhang, En-Hui; Wang, Rufeng; Guo, Shuzhen; Liu, Bin

doi:10.1155/2013/815621

Cited by 54 publications

(44 citation statements)

References 122 publications

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“…As an immunological agent from mulberry leaves, MLPs stimulate immunity and have anti-cancer properties. 5,[18][19][20][21] Early research data both in vitro and in vivo have proven that MLPs can increase both humoral and cellular immunity as evidenced by increased levels of antibody production and through the prevention of death in mice by bovine Pasteurella multocida.…”

Section: Discussionmentioning

confidence: 99%

“…5,21,22 There were articles published previously on the induction of DC by many polysaccharides from plant resources and proved that these polysaccharides played immune enhancing role through DC driving. The results from these studies indicated that the polysaccharides could modulate the number of phagosomes and phagocytosis of DC, ACP activity of DC, expression of key surface co-signals molecules on DC and cytokines production by DC.…”

Section: Discussionmentioning

confidence: 99%

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Mulberry leaf polysaccharides modulate murine bone-marrow-derived dendritic cell maturation

Ming

Sun

Cao³

et al. 2015

Human Vaccines & Immunotherapeutics

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Various components of mulberry leaves, such as iminosugars, flavonoids and polysaccharides, have been reported to exert anti-diabetic activity. The purpose of our present study was to examine the modulating effect of mulberry leaf polysaccharides (MLPs) on murine bone-marrow-derived dendritic cells (BMDCs). The ultrastructure, phenotype and functional maturation of BMDCs were studied using transmission electron microscopy (TEM), flow cytometry (FCM), and tested for phagocytosis, acid phosphatase (ACP) activity using an enzyme linked immunosorbent assay (ELISA). Our results demonstrated that MLPs could markedly induce BMDC maturation by up-regulating the expression of membrane phenotypic markers, such as CD80, CD86, CD83,CD40, and MHC II, down-regulating phagocytosis and ACP activity, and by enhancing the production of interleukin 12 (IL-12) and tumor necrosis factor a (TNF-a) secreted by BMDCs. We therefore concluded that MLPs can positively modulate BMDCs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mulberry leaf polysaccharides modulate murine bone-marrow-derived dendritic cell maturation

Ming

Sun

Cao³

et al. 2015

Human Vaccines & Immunotherapeutics

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“…the anti-inflammatory, the antioxidant, the antiinfective (such as antileishmanial and antimalarial, and anti-tuberculosis), the antiviral, and above all the anticancer and antitumor activities of these compounds. The works of Ni et al (2004), Orlikova et al (2011), Sahu et al (2012 and Zhang et al (2013) are excellent reviews that shed light on the structure and mechanisms of action of chalcones with therapeutic properties. Actually, a number of chalcones have been successfully developed as commercial drugs for treatment of some digestive system diseases; and others are being clinically assayed for the treatment of cancer, cardiovascular diseases, and viral infections (Ni et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Chalcone effects on tumor initiation, invasion and metastasis have been comprehensive reviewed by Orlikova et al (2011) and Zhang et al (2013). The antiproliferative activity of chalcones is due to their capacity to inhibit tubulin assembly and stop uncontrolled proliferation of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Biological Activities and Novel Applications of Chalcones

et al. 2016

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-This review provides information on the biological activities of chalcones (whether natural or synthetic derivatives) on different organisms, as well as an overview of the functions and possible new applications of these plant secondary metabolites on crop protection, as eco-friendly pesticides and weed control agents. Naturally occurring chalcones have been used in traditional medicine for many years; however, recent scientific advances have shown that these molecules have a broad range of biological activities in a variety of organisms. A review on the major sources of chalcones and the main molecular events involved in the modes of action of these natural products is achieved. Chalcones are molecules with a broad spectrum of biological activities, which are of great interest in agriculture to control weeds and unwanted pests.Keywords: mode of action, secondary metabolites, crop protection, pesticide, fungicide, antiviral, phytotoxicity. RESUMO -Esta avaliação fornece informações sobre as atividades biológicas de chalconas (quer derivados naturais ou sintéticos) em diferentes organismos, bem como uma visão geral das funções e eventuais novas aplicações desses metabólitos secundários de plantas em proteção de cultivos e pesticidas orgânicos e para controlar as plantas daninhas. Durante muitos anos têm sido utilizadas na medicina tradicional chalconas de ocorrência natural; no entanto, os recentes avanços científicos têm mostrado que essas moléculas têm vasta gama de atividades biológicas em uma variedade de organismos. Este estudo permite ter uma ideia das principais fontes de chalconas e dos eventos moleculares envolvidos nos principais mecanismos de ação desses produtos naturais. As chalconas são moléculas com um largo espectro de atividade biológica, de grande interesse na agricultura para controlar plantas daninhas e pragas indesejadas.Palavras-chave: modo de ação, metabólitos secundários, proteção de cultivos, pesticida, fungicida, antiviral, fitotoxicidade.

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“…These compounds possess a wide range of pharmacologic properties, including antitumor effects (10)(11)(12). Because most dietary and synthetic polyphenols exhibit negligible toxicity even at relatively high concentrations, polyphenols are promising candidates for use in the development of novel anticancer drugs (13).…”

Section: Introductionmentioning

confidence: 99%

Targeting Cancer Cells via the Reactive Oxygen Species-Mediated Unfolded Protein Response with a Novel Synthetic Polyphenol Conjugate

Shin

Lee²,

Lee³

et al. 2014

Clinical Cancer Research

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Purpose: The selective killing of tumor cells is an important strategy for cancer therapeutics. The aim of this study was to develop a novel antitumor agent that is safe for normal cells with the ability to selectively target cancer cells.Experimental Design: On the basis of quantitative structure-activity relationship, we synthesized a novel polyphenol conjugate (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (DPP-23). We evaluated the effect of DPP-23 on proliferation, cell cycle, and apoptosis in various tumor cells. We also assessed molecular targets of DPP-23 using genome-wide expression profiling by DNA microarray and real-time PCR array systems.Results: DPP-23 effectively inhibited the growth of cancer cells in vitro and in vivo (xenografts in Balb/c nude mice). At a molecular level, DPP-23 targeted the unfolded protein response (UPR) in the endoplasmic reticulum (ER) through the production of reactive oxygen species (ROS) in cancer cells, but not in normal cells, resulting in selective killing of tumor cells via caspase-dependent apoptosis.Conclusions: The selective generation of ROS in cancer cells could be an attractive strategy for the selective killing of cancer cells, while maintaining negligible cytotoxicity to normal cells. DPP-23 represents a promising novel therapeutic agent for the selective production of ROS in cancer cells. Clin Cancer Res; 20(16); 4302-13. Ó2014 AACR.

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An Update on Antitumor Activity of Naturally Occurring Chalcones

Cited by 54 publications

References 122 publications

Mulberry leaf polysaccharides modulate murine bone-marrow-derived dendritic cell maturation

Mulberry leaf polysaccharides modulate murine bone-marrow-derived dendritic cell maturation

Biological Activities and Novel Applications of Chalcones

Targeting Cancer Cells via the Reactive Oxygen Species-Mediated Unfolded Protein Response with a Novel Synthetic Polyphenol Conjugate

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