An Update on Anemia in Less Developed Countries

Tolentino, Karine; Friedman, Jennifer F.

doi:10.4269/ajtmh.2007.77.44

Cited by 211 publications

(226 citation statements)

References 111 publications

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“…Anemia representa uma alteração muitas vezes observada no período neonatal e na infância, que pode levar a significativas morbidade e mortalidade 1,2 . As causas são multifatoriais, mas, entre as mais freqüentes, encontram-se as doenças intrínsecas dos eritrócitos, especialmente as hemoglobinopatias [1][2][3] .…”

Section: Introductionunclassified

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The genetics of blood disorders: the hereditary hemoglobinopathies

Sonati¹,

Costa²

2008

J Pediatr (Rio J)

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ResumoObjetivo: Sumarizar os dados disponíveis na literatura recente sobre os aspectos fisiopatológicos, de diagnóstico e tratamento das doenças falciformes e da talassemia β, hemoglobinopatias hereditárias de maior relevância nas populações. Fontes dos dados AbstractObjective: To summarize recently published data on the pathophysiology, diagnosis and treatment of sickle cell diseases and β-Thalassemias, the most relevant hereditary hemoglobinopathies in the global population.Sources: Searches were run on the MEDLINE and SCIELO databases, limited to the period from 2003 to May 2008, using the terms hereditary hemoglobinopathies, sickle cell diseases and β-thalassemia. Two books and two chapters were also included. Summary of the findings:More than 2,000 articles were identified; those providing the most important information and broadest views were selected.Conclusions: Morbidity and mortality rates from sickle cell diseases and β-thalassemia are still very high and represent an important challenge. Increased understanding of pathophysiological aspects has lead to significant improvements in treatment and prevention of these diseases.

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Section: Introductionunclassified

“…As causas são multifatoriais, mas, entre as mais freqüentes, encontram-se as doenças intrínsecas dos eritrócitos, especialmente as hemoglobinopatias [1][2][3] . Estas representam as formas mais comuns de anemia hemolítica hereditária.…”

Section: Introductionunclassified

The genetics of blood disorders: the hereditary hemoglobinopathies

Sonati¹,

Costa²

2008

J Pediatr (Rio J)

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“…Iron deficiency is the cause of 75% of anaemia cases during pregnancy [5] [10]. HIV infection is also implicated with high prevalence of anaemia in sub-Saharan Africa [11] [12]. Iron deficiency anaemia affects the development of the nation by decreasing the cognitive and motor development of children and productivity of adults [5] [13].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Factors Associated with Anaemia among Pregnant Women Attending Antenatal Clinic in the Second and Third Trimesters at Pumwani Maternity Hospital, Kenya

Okube¹,

Mirie²,

Odhiambo³

et al. 2016

OJOG

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Background: Anaemia is one of the most common nutritional deficiency diseases observed globally and affects more than a quarter of the world's population. Globally, 41.8% pregnant women and close to one third of non-pregnant women (30.2%) are anaemic. Anaemia during pregnancy contributes to 20% of all maternal deaths and it increases the risks of foetal, neonatal and overall infant mortality. In Kenya, according to the Ministry of Health, the prevalence of anaemia among pregnant women is 55.1%. Objective: To determine the prevalence and associated factors of anaemia among pregnant women attending antenatal clinic (ANC) at Pumwani Maternity Hospital (PMH). Methodology: A hospital based cross-sectional study design was conducted from 8 th June to 18 th August, 2015. Systematic random sampling method was used to select 258 pregnant women. Mothers who attended ANC during the study period and who met the inclusion criteria were interviewed and a capillary blood sample was taken. Hemoglobin level was determined by using HemoCue photometer. Data were cleaned, coded and fed into SPSS Version 20.0 for analysis. Descriptive statistics such as frequency, percentage, mean and standard deviation were used to describe selected variables. Pearson's chi-square test and odds ratio (OR) with corresponding 95% confidence intervals (CI) computed to find association between independent and dependent variables. Multivariate analysis was done to determine factors significantly and independently predicting * Corresponding author. O. T. Okube et al. 17anaemia during pregnancy. Results: The present study revealed that the prevalence of anaemia among the pregnant women was 57%. Advanced maternal age (>31 years) (AOR = 2.71; 95% CI = 1.25 -5.88; P = 0.012) more than 18 -24 years, government/private employed women (AOR = 2.94; 95% CI = 1.47 -5.88; P = 0.002) and self-employed women (AOR = 1.91; 95% CI = 1.03 -3.53; P = 0.039) compared to housewives, not taking iron/folic acid supplementation (IFAS) (AOR = 2.04; 95% CI = 1.14 -3.64; P = 0.016) and mid-upper arm circumference (MUAC) less than 23 cm (AOR = 2.52; 95% CI = 1.36 -4.67; P = 0.003) were found to be predictors of anaemia. Conclusion: Anaemia among pregnant women is found to be severe public health problem based on the World Health Organization classification of anaemia. Advanced age, employment, not taking IFAS during the current pregnancy and MUAC of less than 23 cm were significantly and independently associated with anaemia during pregnancy. Thus, special attention should be given to pregnant women who are employed and advanced in age. Moreover, they should be educated on the importance of taking iron and folic acid during pregnancy.

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Section: Introductionmentioning

confidence: 99%

“…1,2 The causes are multifactorial, but some of the most common diseases are intrinsic to the erythrocytes, especially the hemoglobinopathies. [1][2][3] These are the most common forms of hereditary hemolytic anemia. They are a group of autosomal abnormalities, the majority of which are recessive and which are characterized by the production of structurally abnormal hemoglobin (Hb) variants or by an imbalance in the rate of synthesis of the globin chains (thalassemias); less frequently, both phenotypes may be present in the same individual (concomitant reduced synthesis and structural variation).…”

Section: Introductionmentioning

confidence: 99%

Genética das doenças hematológicas: as hemoglobinopatias hereditárias

Sonati¹,

Costa²

2008

J. Pediatr. (Rio J.)

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Objective: To summarize recently published data on the pathophysiology, diagnosis and treatment of sickle cell diseases and β-Thalassemias, the most relevant hereditary hemoglobinopathies in the global population.Sources: Searches were run on the MEDLINE and SCIELO databases, limited to the period from 2003 to May 2008, using the terms hereditary hemoglobinopathies, sickle cell diseases and β-thalassemia. Two books and two chapters were also included. Summary of the findings:More than 2,000 articles were identified; those providing the most important information and broadest views were selected.Conclusions: Morbidity and mortality rates from sickle cell diseases and β-thalassemia are still very high and represent an important challenge. Increased understanding of pathophysiological aspects has lead to significant improvements in treatment and prevention of these diseases. J Pediatr (Rio J). 2008;84(4 Suppl):S40-51:Hereditary hemoglobinopathies, sickle cell diseases, β-thalassemia.

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An Update on Anemia in Less Developed Countries

Cited by 211 publications

References 111 publications

The genetics of blood disorders: the hereditary hemoglobinopathies

The genetics of blood disorders: the hereditary hemoglobinopathies

Prevalence and Factors Associated with Anaemia among Pregnant Women Attending Antenatal Clinic in the Second and Third Trimesters at Pumwani Maternity Hospital, Kenya

Genética das doenças hematológicas: as hemoglobinopatias hereditárias

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