An Update of Twin Research in Spain: The Murcia Twin Registry

Ordoñana, Juan R.; Carrillo, Eduvigis; Colodro‐Conde, Lucía; García-Palomo, Francisco Javier Garcia; González‐Javier, Francisca; Madrid‐Valero, Juan J.; Selva, José María Martínez; Monteagudo, O Pérez; Morosoli, José J.; Pérez-Riquelme, Francisco

doi:10.1017/thg.2019.60

Cited by 17 publications

(13 citation statements)

References 28 publications

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“…Cross-sectional data from a population-based sample of twins registered in the Murcia Twin Register (MTR) (Ordoñana et al, 2006, Ordoñana et al, 2013 were used for this study. The MTR is a community-based twin registry, it is comprised of female and male adult twins who were born between 1940 and 1966 in the Region of Murcia, Spain, and representative of the general population in the region (Ordonana et al, 2017).…”

Section: Methods Participantsmentioning

confidence: 99%

Genetic and environmental influences to low back pain and symptoms of depression and anxiety: A population-based twin study

Pinheiro

Morosoli

Colodro‐Conde

et al. 2018

Journal of Psychosomatic Research

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Section: Methods Participantsmentioning

confidence: 99%

Genetic and environmental influences to low back pain and symptoms of depression and anxiety: A population-based twin study

Pinheiro

Morosoli

Colodro‐Conde

et al. 2018

Journal of Psychosomatic Research

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“…Data came from the Murcia Twin Registry (MTR), a populationbased twin registry of adult multiples born between 1940 and 1976 in the region of Murcia, Southeast of Spain. Information regarding the MTR characteristics and recruitment procedures can be found elsewhere (Ordonana et al, 2019). MTR participants are representative of the general population of the corresponding ages in terms of demographic and health data.…”

Section: Participantsmentioning

confidence: 99%

The Role of the Environment in Overweight and Eating Behavior Variability: Insights from a Multivariate Twin Study

et al. 2020

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Research has emphasized the genetic basis of individual differences in body mass index (BMI); however, genetic factors cannot explain the rapid rise of obesity. Eating behaviors have been stipulated to be the behavioral expression of genetic risk in an obesogenic environment. In this study, we decompose variation and covariation between three key eating behaviors and BMI in a sample of 698 participants, consisting of 167 monozygotic, 150 dizygotic complete same-sex female twins and 64 incomplete pairs from a population-based twin registry in the southeast of Spain, The Murcia Twin Registry. Phenotypes were emotional eating, uncontrolled eating and cognitive restraint, measured by the Three Factor Eating Questionnaire and objectively measured BMI. Variation in eating behaviors was driven by nonshared environmental factors (range: 56%−65%), whereas shared environmental and genetic factors were secondary. All three eating behaviors were correlated with BMI (r = .19–.25). Nonshared environmental factors explained the covariations (Emotional eating–Uncontrolled eating: rE = .54, 95% CI [.43, .64]; BMI–Cognitive restraint: rE = .15, 95% CI [.01, .28]). In contrast to BMI, individual differences in eating behaviors are mostly explained by nonshared environmental factors, which also accounted for the phenotypic correlation between eating behaviors and BMI. Due to the sample size, analyses were underpowered to detect contributions of additive genetic or shared environmental factors to variation and covariation of the phenotypes. Although more research is granted, these results support that eating behaviors could be viable intervention targets to help individuals maintain a healthy weight.

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“…Data came from the Murcia Twin Registry (MTR), a population-based twin registry of adult multiples born between 1940 and 1976 in the region of Murcia, Southeast of Spain. Information regarding the MTR characteristics and recruitment procedures can be found elsewhere (Ordonana et al, 2019). Being a population-based registry with active recruitment, MTR participants are fairly representative of the general population, of the corresponding ages, in terms of demographic and health data.…”

Section: Methodsmentioning

confidence: 99%

The role of the environment in overweight and eating behavior variability: Insights from a multivariate twin study

Herle

Madrid‐Valero

Morosoli

et al. 2020

Preprint

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The health consequences of overweight and obesity remain one of the greatest global health challenges. Twin and molecular studies have confirmed the genetic basis of individual differences in BMI; however, genetics cannot explain the rapid rise of obesity rates over the past decades. Eating behaviors have been stipulated to be the behavioral expression of genetic risk in an obesogenic environment. Multivariate twin studies can inform future applied research by providing insights into the etiology of the relationship between behaviors and BMI. In this study, we aimed to decompose variation and covariation between three key eating behaviors and BMI in a sample from a population-based twin registry of adult women in the southeast of Spain, The Murcia Twin Registry (345 complete, 9 incomplete, same sex female twin pairs, 175 MZ, 170 DZ). Phenotypes were emotional eating, uncontrolled eating, and cognitive restraint, as measured by the Three Factor Eating Questionnaire, as well as objectively measured BMI. Variation in eating behaviors was mostly driven by non-shared environmental factors (range: 56, 65%), whereas shared environmental and genetic factors were secondary. All three eating behaviors were associated with BMI at a phenotypic level (range r=0.19, 0.25). Etiological correlations implied that non-shared environmental factors underlie the covariations of the phenotypes (Emotional eating & Uncontrolled eating: rE= 0.54, 95%CI: 0.43, 0.64; BMI & Cognitive restraint: rE= 0.15, 95%CI: 0.01, 0.28). Results indicate that in contrast to BMI, individual differences in eating behaviors are mostly explained by non-shared environmental factors, which also account for the phenotypic correlation between eating behaviors and BMI. These results support that eating behaviors are viable intervention targets to help individuals reach and maintain a healthy weight.

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An Update of Twin Research in Spain: The Murcia Twin Registry

Cited by 17 publications

References 28 publications

Genetic and environmental influences to low back pain and symptoms of depression and anxiety: A population-based twin study

Genetic and environmental influences to low back pain and symptoms of depression and anxiety: A population-based twin study

The Role of the Environment in Overweight and Eating Behavior Variability: Insights from a Multivariate Twin Study

The role of the environment in overweight and eating behavior variability: Insights from a multivariate twin study

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