An update of the effects of vitamins D and C in critical illness

Hill, Aileen; Starchl, Christina; Dresen, Ellen; Stoppe, Christian; Amrein, Karin

doi:10.3389/fmed.2022.1083760

Cited by 9 publications

(23 citation statements)

References 131 publications

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“…It has been widely remarked that urinary tract infections are a strong predictor of mortality and complications for stone surgery [31]. Other factors related to a poor clinical outcome in critical illness, such as vitamin D deficiency, are frequently found in lithiasic patients [32]. Therefore, our findings suggest a higher mortality in elderly patients influenced by a higher prevalence of urinary tract infections.…”

Section: Discussionmentioning

confidence: 49%

“…Furthermore, other comorbidity diseases have been pointed out as predictors of mortality in treated lithiasis patients, such as gender, body mass index, diabetes, cardiovascular diseases, and vitamin deficiency [29,31,32]. In this paper, age, diabetes mellitus, and hypertension have been shown to be mortality predictors both in univariate and multivariate analyses.…”

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

Hospitalization Burden of Patients with Kidney Stones and Metabolic Comorbidities in Spain during the Period 2017–2020

et al. 2023

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Nephrolithiasis has become an increasing worldwide problem during the last decades. Metabolic syndrome, its components, and related dietary factors have been pointed out as responsible for the increasing incidence. The objective of this study was to evaluate the trends in the hospitalization rates of patients with nephrolithiasis, hospitalization features, costs, and how metabolic syndrome traits influence both the prevalence and complications of lithiasic patients. An observational retrospective study was conducted by analyzing hospitalization records from the minimum basic data set, including all patient hospitalizations in Spain in which nephrolithiasis has been coded as a main diagnosis or as a comorbidity during the period 2017–2020. A total of 106,407 patients were hospitalized and coded for kidney or ureteral lithiasis in this period. The mean age of the patients was 58.28 years (CI95%: 58.18–58.38); 56.8% were male, and the median length of stay was 5.23 days (CI95%: 5.06–5.39). In 56,884 (53.5%) patients, kidney or ureteral lithiasis were coded as the main diagnosis; the rest of the patients were coded mostly as direct complications of kidney or ureteral stones, such as “non-pecified renal colic”, “acute pyelonephritis”, or “tract urinary infection”. The hospitalization rate was 56.7 (CI95%: 56.3–57.01) patients per 100,000 inhabitants, showing neither a significant increasing nor decreasing trend, although it was influenced by the COVID-19 pandemic. The mortality rate was 1.6% (CI95%: 1.5–1.7), which was higher, if lithiasis was coded as a comorbidity (3.4% CI95%: 3.2–3.6). Metabolic syndrome diagnosis component codes increased the association with kidney lithiasis when age was higher, reaching the highest in the eighth decade of life. Age, diabetes, and hypertension or lithiasis coded as a comorbidity were the most common causes associated with the mortality of lithiasic patients. In Spain, the hospitalization rate of kidney lithiasis has remained stable during the period of study. The mortality rate in lithiasic patients is higher in elderly patients, being associated with urinary tract infections. Comorbidity conditions such as diabetes mellitus and hypertension are mortality predictors.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 80%

Hospitalization Burden of Patients with Kidney Stones and Metabolic Comorbidities in Spain during the Period 2017–2020

et al. 2023

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“…Maintenance of body calcium stores depends on dietary calcium intake, absorption from the gastrointestinal tract, and renal calcium excretion. PTH enhances distal tubular calcium reabsorption, independently of sodium, while proximal tubule calcium excretion is sodium dependent [12].…”

Section: Key Pointsmentioning

confidence: 99%

“…Critically ill patients are prone to reduced serum levels of vitamin C [12]. Whilst there have been no reports of the effect of vitamin C supplementation on bone health in critically ill patients, there has been significant interest on high-dose IV vitamin C particularly in sepsis.…”

Section: Vitamin Cmentioning

confidence: 99%

Micronutrient intake to protect against osteoporosis during and after critical illness

Nair,

Orford,

Kerschan-Schindl

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Improved survival from critical illness has enhanced the focus on ways to augment functional outcomes following discharge from the Intensive Care Unit. An area that is gaining increased attention is the effect of critical illness on bone health and fragility fractures following the episode. This review discusses the micronutrients that may play a role in bone metabolism and the potential benefits of their supplementation to prevent osteoporosis. These include calcium, phosphorous, magnesium, vitamin D, vitamin C, vitamin K, and certain trace elements. Findings Although there is sound physiological basis for the involvement of these micronutrients in bone health and fracture prevention, there are few clinically relevant publications in this area with calcium and vitamin D being the best studied to date. Summary In the absence of high-quality evidence in critically ill populations, attention to measurement and supplementation of these micronutrients as per current guidelines outlining micronutrient requirements in enteral and parenteral nutrition might mitigate bone loss and its sequelae in the recovery phase from critical illness.

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“…68,70 Vitamin D insufficiency was associated with musculoskeletal disease, cognitive decline, cancers (breast, colon, prostate), cardiovascular disease, hypertension, dyslipidemia, autoimmune disease, kidney injury, infection, and mortality. [66][67][68][70][71][72]74,76,77 Vitamin D has many natural and synthetic analogs. The natural analogs of vitamin D mainly involves in human are vitamin D 2 (ergocalciferol) which found in plant and fungi, and vitamin D 3 (cholecalciferol).…”

Section: Vitamin D Air Pollution and Effects On Organ Transplantationmentioning

confidence: 99%

Impact of air pollution on postoperative outcomes following organ transplantation: Evidence from clinical investigations

Supphapipat,

Leurcharusmee,

Chattipakorn

et al. 2023

Clinical Transplantation

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IntroductionAir pollution is a worldwide problem affecting human health via various body systems, resulting in numerous significant adverse events. Air pollutants, including particulate matter < or = 2.5 microns (PM2.5), particulate matter < or = 10 microns (PM10), ozone (O3), nitrogen dioxide (NO2), and traffic‐related air pollution (TRAP), have demonstrated the negative effects on human health (e.g., increased cerebrovascular, cardiovascular, and respiratory diseases, malignancy, and mortality). Organ transplant patients, who are taking immunosuppressive agents, are especially vulnerable to the adverse effects of air pollutants. The evidence from clinical investigation has shown that exposure to air pollution after organ transplantation is associated with organ rejection, cardiovascular disease, coronary heart disease, cerebrovascular disease, infection‐related mortality, and vitamin D deficiency.Objectives and methodThis review aims to summarize and discuss the association of exposure to air pollutants and serum 25‐hydroxyvitamin D level and outcomes after transplantation. Controversial findings are also included and discussed.ConclusionAll of the findings suggest that air pollution results in a hazardous environment, which not only impacts human health worldwide but also affects post‐transplant outcomes.

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An update of the effects of vitamins D and C in critical illness

Cited by 9 publications

References 131 publications

Hospitalization Burden of Patients with Kidney Stones and Metabolic Comorbidities in Spain during the Period 2017–2020

Hospitalization Burden of Patients with Kidney Stones and Metabolic Comorbidities in Spain during the Period 2017–2020

Micronutrient intake to protect against osteoporosis during and after critical illness

Impact of air pollution on postoperative outcomes following organ transplantation: Evidence from clinical investigations

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