An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis

Speck, Rebecca M.; Courneya, Kerry S.; Mâsse, Louise C.; Duval, Sue; Schmitz, Kathryn H.

doi:10.1007/s11764-009-0110-5

Cited by 1,128 publications

(1,021 citation statements)

References 112 publications

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“…These findings are also in line with Speck and colleagues [5] who, based on eight trials, concluded with small to moderate effect of physical exercise on muscle strength.…”

Section: Effects Of Physical Exercisesupporting

confidence: 91%

“…The findings are in line with a systematic review and a meta-analysis by Speck et al [5] based on five trials reporting muscle mass as outcome. This review concluded with small effects sizes in favour of different physical activity interventions compared with usual care in cancer survivors.…”

Section: Effects Of Physical Exercisesupporting

confidence: 90%

“…Physical exercise has in general a positive impact on many biological processes such as energy expenditure, insulin resistance, inflammation and most body organs and tissues. In cancer patients, there is evidence that physical exercise contributes to reduce fatigue [1], improves quality of life [2,3] and relieves many of the adverse side-effects experienced both during and after treatment [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…However, a range of factors beyond those usually encountered when providing exercise advice in healthy populations must be considered, especially in patients who are undergoing cancer treatment or experience adverse side-effects of treatment [9,10]. Physical exercise is considered to be welltolerated, feasible and safe during and following cancer treatment [5,11] and even cancer patients with advanced stages of disease are willing to engage in physical exercise [12]. Thus, based on current knowledge, it is considered clinically sound to advise most cancer patient to perform physical exercise.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Stene¹,

Helbostad²,

Balstad³

et al. 2013

Critical Reviews in Oncology/Hematology

171

105

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“…These findings are also in line with Speck and colleagues [5] who, based on eight trials, concluded with small to moderate effect of physical exercise on muscle strength.…”

Section: Effects Of Physical Exercisesupporting

confidence: 91%

Section: Effects Of Physical Exercisesupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Stene¹,

Helbostad²,

Balstad³

et al. 2013

Critical Reviews in Oncology/Hematology

171

105

View full text Add to dashboard Cite

“…Participating specialist practitioners who were physiotherapists also suggested that the role of physical activity, especially in the management of fatigue and breathlessness, should be incorporated as a key component of RDSI rather than only appearing in the written information. Given the strong evidence base for structured activity in the management of cancer‐related symptoms (Schwartz, Mori, Gao, Nail, & King, 2001; Speck, Courneya, Mâsse, Duval, & Schmitz, 2010) this has been added as a key component to RDSI.…”

Section: Discussionmentioning

confidence: 99%

Participation in a randomised controlled feasibility study of a complex intervention for the management of the Respiratory Symptom Distress Cluster in lung cancer: patient, carer and research staff views

et al. 2016

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This paper reports finding from a nested qualitative study designed to elicit the views and perceptions of those who participated in a randomised controlled feasibility trial testing a non‐pharmacological intervention, Respiratory Distress Symptom Intervention (RDSI), for the management of the breathlessness–cough–fatigue symptom cluster in lung cancer. Semi‐structured interviews were conducted with 11 lung cancer patients, three caregivers and seven researchers involved in recruitment, consent, RDSI training and delivery and participant follow‐up. Thematic analysis identified key considerations including: the importance of informed consent emphasising commitment to completion of paperwork and raising awareness of potential sensitivities relating to content of questionnaires; ensuring screening for the presence of symptoms reflects the language used by patients; appreciation of the commitment required from participants to learn intervention techniques and embed them as part of everyday life; conduct of interviews with patients who decline to participate; and conduct of serial interviews with those receiving RDSI to further inform its routine implementation into clinical practice. This study will inform the development of a fully powered follow‐on trial testing the hypothesis that RDSI plus usual care is superior to usual care alone in the effective management of this symptom cluster in lung cancer.

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Midlife Cardiorespiratory Fitness, Incident Cancer, and Survival After Cancer in Men

et al. 2015

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Importance Cardiorespiratory fitness (CRF) as assessed by formalized incremental exercise testing is a strong independent predictor of numerous chronic diseases but has received little attention as a predictor of incident cancer or survival following a diagnosis of cancer. Objective To assess the association between midlife CRF and incident cancer and survival following a cancer diagnosis. Design Prospective, observational cohort study. Setting Preventive medicine clinic Participants and Exposures The prospective, observational cohort study included 13,949 community-dwelling men who had a baseline fitness examination. All men completed a comprehensive medical examination, a cardiovascular risk factor assessment, and incremental treadmill exercise test to evaluate CRF. We utilized age-sex specific distribution of treadmill duration from the overall CCLS population to define fitness groups as low (lowest 20%), moderate (middle 40%), and high (upper 40%) fit groups. The adjusted multivariable model included: age, exam year, body mass index, smoking, total cholesterol, systolic blood pressure, diabetes, fasting glucose. Main Outcome Measures (1) Incident prostate, lung, and colorectal cancer, and (2) all-cause mortality and cause-specific mortality among men who developed cancer are Medicare age (on or after age 65 years). Results Compared to low CRF, the adjusted hazard ratio (HR) for incident lung, colorectal, and prostate cancer among men with high CRF was 0.45 (95% CI: 0.29-0.68), 0.56 (95% CI: 0.36-0.87), 1.22 (95% CI: 1.02-1.46), respectively. Among those diagnosed with cancer at Medicare age (65 years), high CRF in mid-life was associated with an adjusted 36% (HR 0.64, 95% CI: 0.45-0.93) risk reduction in all cancer related deaths and a 69% reduction in cardiovascular disease mortality following a cancer diagnosis (HR 0.31, 95% CI: 0.15-0.62) compared to low fit men in mid-life. Conclusions and Relevance There is a strong inverse relationship between midlife CRF and incident lung and colorectal cancer but not prostate cancer. High mid-life CRF is also protective against the risk of cause-specific mortality in those diagnosed with cancer at Medicare age.

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An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis

Abstract: Current evidence suggests many health benefits from physical activity during and post cancer treatments. Additional studies are needed in cancer diagnoses other than breast and with a focus on survivors in greatest need of improvements for the health outcomes of interest.

Cited by 1,128 publications

References 112 publications

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Participation in a randomised controlled feasibility study of a complex intervention for the management of the Respiratory Symptom Distress Cluster in lung cancer: patient, carer and research staff views

Midlife Cardiorespiratory Fitness, Incident Cancer, and Survival After Cancer in Men

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