An update of Brachyspira hyodysenteriae serotyping

Herbst, W.; Schneider, Simone; Baljer, G.; Barth, Stefanie A.

doi:10.1016/j.rvsc.2017.02.015

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Based on LOS, B. hyodysenteriae has 11 serotypes widely distributed in different geographic regions. Genetic variation and marked differences in antigenic proteins are significant limitations for development of a globally applicable serological test [36]. Some studies using recombinant proteins have been carried out to develop a serological test that would be an important tool for detecting B. hyodysenteriae positive herds without clinical signs of SD [21,37].…”

Section: Discussionmentioning

confidence: 99%

Experimental Infection of Pigs with a ST 245 Brachyspira hyodysenteriae Isolated from an Asymptomatic Pig in a Herd with No History of Swine Dysentery

Sato

Daniel

Pereira

et al. 2022

Veterinary Sciences

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Swine dysentery (SD) is characterized by a severe mucohemorrhagic colitis caused by infection with Brachyspira species. In infected herds the disease causes considerable financial loss due to mortality, slow growth rates, poor feed conversion, and costs of treatment. B. hyodysenteriae is the most common etiological agent of SD and infection is usually associated with disease. However, isolated reports have described low pathogenic strains of B. hyodysenteriae. The aim of this study was to describe an experimental infection trial using a subclinical B. hyodysenteriae isolated from an animal without clinical signs and from a disease-free herd, to evaluate the pathogenicity and clinical pathological characteristics compared to a highly clinical isolate. Forty-eight 5-week-old pigs were divided into three groups: control, clinical and the subclinical isolates. The first detection/isolation of B. hyodysenteriae in samples of the animals challenged with a known clinical B. hyodysenteriae strain (clinical group) occurred 5th day post inoculation. Considering the whole period of the study, 11/16 animals from this group were qPCR positive in fecal samples, and diarrhea was observed in 10/16 pigs. In the subclinical isolate group, one animal had diarrhea. There were SD large intestine lesions in 3 animals at necropsy and positive B. hyodysenteriae isolation in 7/15 samples of the subclinical group. In the control group, no diarrhea, gross/microscopic lesions, or qPCR positivity were observed. Clinical signs, bacterial isolation, macroscopic and histologic lesions were significantly difference among groups, demonstrating low pathogenicity of the subclinical isolate in susceptible pigs.

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Section: Discussionmentioning

confidence: 99%

Experimental Infection of Pigs with a ST 245 Brachyspira hyodysenteriae Isolated from an Asymptomatic Pig in a Herd with No History of Swine Dysentery

Sato

Daniel

Pereira

et al. 2022

Veterinary Sciences

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“…A bactéria L. intracellularis está disseminada mundialmente, causando prejuízos nos sistemas de produção de suínos (HOLTSKMP, 2020;RESENDE et al, 2015). A EPS foi detectada em diversos países, dos 144 rebanhos testados na Alemanha, Dinamarca, Espanha, Holanda e Reino Unido 90,3% continham pelo menos uma amostra fecal positiva para L. intracellularis (ARNOLD et al, 2019;CHOUET et al, 2003;HANDS et al, 2010;HERBST et al, 2004;JACOBSON et al, 2005;STEGE et al, 2000). Na América do Sul, em granjas nas regiões metropolitanas da Colômbia, foi detectado o genoma da bactéria em 31% dos animais testados.…”

Section: Prevalênciaunclassified

Lawsonia intracellularis: INFECÇÃO E PROFILAXIA

Conrad,

Mazzoleni,

Costa

et al. 2023

SCI. ANIM. HEALTH

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Lawsonia intracellularis é uma bactéria Gram-negativa intracelular obrigatória que causa a Enteropatia Proliferativa Suína (EPS), uma doença economicamente importante para a suinocultura. A infecção é caracterizada pela hiperplasia da mucosa intestinal, desencadeando sinais clínicos como diarreia, perda de peso e, em alguns casos, morte súbita. A prevalência das infecções em escala mundial é difícil de ser estimada devido a presença de animais assintomáticos e difícil diagnóstico diferencial, tornando incalculáveis as perdas econômicas decorrentes da infecção. A compreensão da patogênese de L. intracellularis, especialmente como o hospedeiro responde à infecção e os fatores que influenciam para os diferentes desfechos clínicos é essencial para que intervenções apropriadas sejam realizadas. A vacinação é a melhor medida profilática contra EPS, contudo as vacinas disponíveis apresentam limitações, motivando pesquisadores à busca de novos antígenos, estratégias e sistemas de entrega vacinais que proporcionem a resposta imune protetora à L. intracellularis. Neste estudo revisamos os principais fatores relacionados à patogenicidade de L. intracellularis e os principais aspectos da resposta vacinal. Além disso, a revisão aborda o cenário de vacinas disponíveis e em desenvolvimento contra L. intracelullaris, incluindo os principais epítopos e estratégias que vem sendo estudadas.

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“…In addition to diet manipulation, vaccination is another strategy to prevent disease associated losses. Although vaccines have been successfully developed for many porcine pathogens, attempts to develop vaccines for certain pathogens, such as B. hyodysenteriae, have been largely unsuccessful (Herbst et al, 2017). For L. intracellularis, there are two commercially available vaccines, a live attenuated vaccine (Enterisol ® , Boehringer Ingelheim) and an inactivated vaccine (Porcilis ® Ileitis, Merck Animal Health, Madison, NJ, USA).…”

Section: Chapter 6 General Discussionmentioning

confidence: 99%

Pathogenic disease modulation of pig intestinal function and integrity

Helm¹

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An update of Brachyspira hyodysenteriae serotyping

Cited by 5 publications

References 29 publications

Experimental Infection of Pigs with a ST 245 Brachyspira hyodysenteriae Isolated from an Asymptomatic Pig in a Herd with No History of Swine Dysentery

Experimental Infection of Pigs with a ST 245 Brachyspira hyodysenteriae Isolated from an Asymptomatic Pig in a Herd with No History of Swine Dysentery

Lawsonia intracellularis: INFECÇÃO E PROFILAXIA

Pathogenic disease modulation of pig intestinal function and integrity

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