An update in clinical utilization of photodynamic therapy for lung cancer

Wang, Kai; Yu, Boxin; Pathak, Janak L.

doi:10.7150/jca.51537

Cited by 82 publications

(49 citation statements)

References 89 publications

(106 reference statements)

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“…Optimum drug-light intervals are mostly assumed to be the times at which there is a maximum differential in PS retention between the tumor and normal tissue ( Cramers et al, 2003 ). However, optimum drug-light interval might vary from patient to patient or lesion to lesion ( Wang et al, 2021 ). Such variations render the application of standardized protocols difficult.…”

Section: Clinical Applications Of Photodynamic Therapy In Cancermentioning

confidence: 99%

“…PDT alone was reported to be an important alternative treatment to palliative chemotherapy or radiotherapy in lung cancer. It results in a response rate of approximately 87% as well as improving the patient’s quality of life ( Wang et al, 2021 ). In a study conducted on A549 lung cancer cells, PDT mediated with a nanobody complex (Nb@IC-NPs) was able to effectively destruct tumor cells and improve survival in mice ( Zhang et al, 2020 ).…”

Section: Photodynamic Therapy In Different Types Of Cancersmentioning

confidence: 99%

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Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

2021

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Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long time and photosensitizers (PS) can be used in various types of tumors. Originally, light is an effective tool that has been used in the treatment of diseases for ages. The effects of combination of specific dyes with light illumination was demonstrated at the beginning of 20th century and novel PDT approaches have been developed ever since. Main strategies of current studies are to reduce off-target effects and improve pharmacokinetic properties. Given the high interest and vast literature about the topic, approval of PDT as the first drug/device combination by the FDA should come as no surprise. PDT consists of two stages of treatment, combining light energy with a PS in order to destruct tumor cells after activation by light. In general, PDT has fewer side effects and toxicity than chemotherapy and/or radiotherapy. In addition to the purpose of treatment, several types of PSs can be used for diagnostic purposes for tumors. Such approaches are called photodynamic diagnosis (PDD). In this Review, we provide a general overview of the clinical applications of PDT in cancer, including the diagnostic and therapeutic approaches. Assessment of PDT therapeutic efficacy in the clinic will be discussed, since identifying predictors to determine the response to treatment is crucial. In addition, examples of PDT in various types of tumors will be discussed. Furthermore, combination of PDT with other therapy modalities such as chemotherapy, radiotherapy, surgery and immunotherapy will be emphasized, since such approaches seem to be promising in terms of enhancing effectiveness against tumor. The combination of PDT with other treatments may yield better results than by single treatments. Moreover, the utilization of lower doses in a combination therapy setting may cause less side effects and better results than single therapy. A better understanding of the effectiveness of PDT in a combination setting in the clinic as well as the optimization of such complex multimodal treatments may expand the clinical applications of PDT.

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Section: Clinical Applications Of Photodynamic Therapy In Cancermentioning

confidence: 99%

Section: Photodynamic Therapy In Different Types Of Cancersmentioning

confidence: 99%

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

2021

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“…Finally, some reviews have covered specific topics in recent years, e.g., nanoparticle photosensitizer drug delivery uptake systems [63] or a combination of PDT and chemotherapy [65]. Additionally, an update of clinical trials can be found in [64].…”

Section: Lung Cancermentioning

confidence: 99%

Photodynamic Therapy: A Compendium of Latest Reviews

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

182

140

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Photodynamic therapy (PDT) is a promising therapy against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present a brief compendium of reviews of the last two decades classified under different topics, namely, overviews, reviews about specific cancers, and meta-analyses of photosensitisers, PDT mechanisms, dosimetry, and light sources. The key issues and main conclusions are summarized, including ways and means to improve therapy and outcomes. Due to the broad scope of this work and it being the first time that a compendium of the latest reviews has been performed for PDT, it may be of interest to a wide audience.

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“…I-PDT using lasers has been applied successfully to different treatment sites with localised tumours [ 49 ]. For instance, head and neck [ 54 ], pancreas [ 55 ], prostate [ 41 , 56 ], lung [ 57 ], brain [ 58 ], and more recently primary breast cancer [ 59 , 60 ]. In most cases, I-PDT has the main advantage to improve treatment outcomes for patients in which the standard of care therapy failed or needs better treatment options [ 49 ].…”

Section: Light Technology For Pdtmentioning

confidence: 99%

Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

Algorri

Ochoa

Roldán-Varona

et al. 2021

Cancers

104

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Photodynamic therapy (PDT) is a cancer treatment with strong potential over well-established standard therapies in certain cases. Non-ionising radiation, localisation, possible repeated treatments, and stimulation of immunological response are some of the main beneficial features of PDT. Despite the great potential, its application remains challenging. Limited light penetration depth, non-ideal photosensitisers, complex dosimetry, and complicated implementations in the clinic are some limiting factors hindering the extended use of PDT. To surpass actual technological paradigms, radically new sources, light-based devices, advanced photosensitisers, measurement devices, and innovative application strategies are under extensive investigation. The main aim of this review is to highlight the advantages/pitfalls, technical challenges and opportunities of PDT, with a focus on technologies for light activation of photosensitisers, such as light sources, delivery devices, and systems. In this vein, a broad overview of the current status of superficial, interstitial, and deep PDT modalities—and a critical review of light sources and their effects on the PDT process—are presented. Insight into the technical advancements and remaining challenges of optical sources and light devices is provided from a physical and bioengineering perspective.

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An update in clinical utilization of photodynamic therapy for lung cancer

Cited by 82 publications

References 89 publications

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

Photodynamic Therapy: A Compendium of Latest Reviews

Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

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