An update and review of narrowband ultraviolet B phototherapy for vitiligo

Wang, Eugene; Rodrigues, Michelle

doi:10.1002/der2.142

Cited by 3 publications

(2 citation statements)

References 86 publications

(241 reference statements)

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“…The oxidative modification of HSA was assessed based on the decrease in fluorescence in the region of 350 nm (fluorescence of tryptophan and tyrosine) upon excitation at 280 nm. The light with the spectral range of 308 ± 10 nm, used in the treatment of vitiligo [18,42,43], was considered as the source of oxidative stress. Figure 8a shows the HSA fluorescence spectra before and after irradiation at 308 nm for 16 min.…”

Section: Study Of Hsa Oxidative Modification With Fluorescencementioning

confidence: 99%

Tetrahydrobiopterin as a Trigger for Vitiligo: Phototransformation during UV Irradiation

Telegina,

Vechtomova,

Borzova

et al. 2023

IJMS

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Vitiligo is a type of hypomelanosis. Tetrahydrobiopterin (H4Bip), the coenzyme of the initial stage of melanogenesis, appears to be a trigger for vitiligo. H4Bip is present in vitiligo in 3–5-fold excess and causes oxidative stress by triggering an autocatalytic cycle of excess hydrogen peroxide synthesis. Using quantum-chemical calculations, we have evaluated the possibility of H4Bip reactions occurring in the dark and under ultraviolet (UV) irradiation, including the formation of dihydropterin dimers. In order to simulate the oxidative stress, oxidative modification of human serum albumin (HSA) has been carried out in the presence of excessive H4Bip using the fluorescence method. The fraction of oxidized protein (FOP) has been calculated. It has been established that there is a strong oxidative modification of amino acids chromophores (tryptophan and tyrosine) in the protein (FOP 0.64). Under UV irradiation of the system (HSA + H4Bip), FOP is reduced to 0.39. Apparently, a part of H4Bip transforms into dihydropterin dimers and does not participate in the oxidative modification of the protein. The data on oxidative modification of HSA are consistent with dynamic light scattering: H4Bip promotes HSA aggregation with the formation of particles with a hydrodynamic radius Rh ≥ 2000 nm, which can become immunogenic.

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Section: Study Of Hsa Oxidative Modification With Fluorescencementioning

confidence: 99%

Tetrahydrobiopterin as a Trigger for Vitiligo: Phototransformation during UV Irradiation

Telegina,

Vechtomova,

Borzova

et al. 2023

IJMS

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“…[76]; [132]; [133] ; [134]; [135] [136 ]; [137]; [138]; [1 39]; [140] Focused on PUVA: [141]; [142]; [143]…”

Section: Vitiligomentioning

confidence: 99%

Clinical Applications of Polypodium leucotomos (Fernblock®): An Update

Rodríguez-Luna¹,

Zamarrón²,

Juarranz³

et al. 2023

Preprint

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Exposure to sun radiation leads to higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition to ultraviolet radiation (UVR), recent research indicates that infrared radiation (IR) and visible light (VIS) can play an important role in the pathogenesis of some of these processes. Detrimental effects associated to sun exposure are well known, but new studies have shown that DNA damage continues to occur long after exposure to solar radiation has ended. Regarding photoprotection strategies, natural substances are emerging for topical and oral photoprotection. In this sense, Fernblock®, a standardized aqueous extract of the fern Polypodium Leucotomos (PLE), has been widely administered both topically and orally with a strong safety profile. Thus, this extract has been used extensively in clinical practice, including as a complement to photodynamic therapy (PDT) for treating actinic keratoses (AKs) and field cancerization. It has also been used to treat skin diseases such as photodermatoses, photoaggravated inflammatory conditions and pigmentary disorders. This review examines the most recent developments in the clinical application of Fernblock® and assesses how newly investigated action mechanisms may influence its clinical use.

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Clinical Applications of Polypodium leucotomos (Fernblock®): An Update

Rodríguez-Luna

Zamarrón

Juarranz

et al. 2023

Life

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Exposure to sun radiation leads to higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition to ultraviolet radiation (UVR), recent research indicates that infrared radiation (IR) and visible light (VIS) can play an important role in the pathogenesis of some of these processes. Detrimental effects associated with sun exposure are well known, but new studies have shown that DNA damage continues to occur long after exposure to solar radiation has ended. Regarding photoprotection strategies, natural substances are emerging for topical and oral photoprotection. In this sense, Fernblock®, a standardized aqueous extract of the fern Polypodium Leucotomos (PLE), has been widely administered both topically and orally with a strong safety profile. Thus, this extract has been used extensively in clinical practice, including as a complement to photodynamic therapy (PDT) for treating actinic keratoses (AKs) and field cancerization. It has also been used to treat skin diseases such as photodermatoses, photoaggravated inflammatory conditions and pigmentary disorders. This review examines the most recent developments in the clinical application of Fernblock® and assesses how newly investigated action mechanisms may influence its clinical use.

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An update and review of narrowband ultraviolet B phototherapy for vitiligo

Cited by 3 publications

References 86 publications

Tetrahydrobiopterin as a Trigger for Vitiligo: Phototransformation during UV Irradiation

Tetrahydrobiopterin as a Trigger for Vitiligo: Phototransformation during UV Irradiation

Clinical Applications of Polypodium leucotomos (Fernblock®): An Update

Clinical Applications of Polypodium leucotomos (Fernblock®): An Update

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