An Up-to-Date Review of Biomaterials Application in Wound Management

Niculescu, Adelina-Gabriela; Grumezescu, Valentina

doi:10.3390/polym14030421

Cited by 70 publications

(44 citation statements)

References 143 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinically, the fact that the oil is incorporated into the gel is beneficial for healing, since the gauze adheres less, causing less pain, and less risk of removing newly formed tissue [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

rhEGF-Loaded Hydrogel in the Treatment of Chronic Wounds in Patients with Diabetes: Clinical Cases

Oliveira

Deutsch

et al. 2022

Gels

View full text Add to dashboard Cite

The aim of the study was to evaluate the healing process of chronic wounds treated with carboxymethylcellulose loaded with recombinant human epidermal growth factor in patients with diabetes. The case series consisted of 10 patients treated at the university hospital for 12 weeks. Data were analyzed using SPSS version 22.0. according to the intention to treat the principle, without the loss or exclusion of the participants. The sample consisted of 70% (7/10) males with a mean age of 61.9 years (±9.4); all (100%) had diabetes mellitus and 70% (7/10) had systolic hypertension associated with diabetes mellitus. Sixty percent (6/10) presented lesions of diabetic etiology and 40% (4/10) presented lesions of venous etiology; 70% (7/10) had had lesions for less than 5 years. The mean glycated hemoglobin was 7.8% (±2.7%), while the mean ankle-arm index (AAI) was 0.94 (±0.21). The mean initial area of all wounds was 13.4 cm², and the mean final area was 7.8 cm2, with a reduction rate of 28.9% over the 12 weeks of treatment. The reduction rate of diabetic ulcers was higher (33.4%) than that of venous ulcers (22.1%). Regarding the type of tissue, there was an increase in granulation and epithelialization, and a decrease in slough and the amount of exudate that were statistically significant (p = 0.021). No participant had severe or local adverse events during the study period. Epidermal growth factor was effective in the treatment of chronic wounds, especially diabetic ulcers, resulting in the reduction of the wound area and the improvement of tissue and exudate quality.

show abstract

Section: Discussionmentioning

confidence: 99%

rhEGF-Loaded Hydrogel in the Treatment of Chronic Wounds in Patients with Diabetes: Clinical Cases

Oliveira

Deutsch

et al. 2022

Gels

View full text Add to dashboard Cite

show abstract

“…An ideal wound dressing should maintain a moist environment, absorb exudates, support angiogenesis, allow gaseous exchange, create thermal insulation in the wound area, and prevent microbial infections. It should have characteristics such as being non-toxic, non-adherent, and non-allergenic, and should be easy to remove without trauma and made with minimal processing and cost-effective material wound healing such as re-epithelialization, autolytic debridement granulation tissue formation, and inflammation [ 41 ].…”

Section: Applicationsmentioning

confidence: 99%

Bacterial Cellulose and Its Applications

Choi

Rao

et al. 2022

Polymers

View full text Add to dashboard Cite

The sharp increase in the use of cellulose seems to be in increasing demand in wood; much more research related to sustainable or alternative materials is necessary as a lot of the arable land and natural resources use is unsustainable. In accordance, attention has focused on bacterial cellulose as a new functional material. It possesses a three-dimensional, gelatinous structure consisting of cellulose with mechanical and thermal properties. Moreover, while a plant-originated cellulose is composed of cellulose, hemi-cellulose, and lignin, bacterial cellulose attributable to the composition of a pure cellulose nanofiber mesh spun is not necessary in the elimination of other components. Moreover, due to its hydrophilic nature caused by binding water, consequently being a hydrogel as well as biocompatibility, it has only not only used in medical fields including artificial skin, cartilage, vessel, and wound dressing, but also in delivery; some products have even been commercialized. In addition, it is widely used in various technologies including food, paper, textile, electronic and electrical applications, and is being considered as a highly versatile green material with tremendous potential. However, many efforts have been conducted for the evolution of novel and sophisticated materials with environmental affinity, which accompany the empowerment and enhancement of specific properties. In this review article, we summarized only industry and research status regarding BC and contemplated its potential in the use of BC.

show abstract

“…The current literature defines wounds as a damaging process involving the integrity of skin and mucous membranes and other deeper tissues. Researchers either describe the wound healing process as being comprised of either four overlapping phases—hemostasis, inflammation, proliferation, and remodeling—or three overlapping phases: (a) inflammatory, fibroblastic, and maturing, or (b) inflammatory, proliferation, and remodeling [ 16 , 17 , 18 , 19 , 20 ]. Wound contraction is the last stage of the wound healing process, usually overlapped with the remodeling phase [ 21 , 22 ].…”

Section: Wound Healingmentioning

confidence: 99%

Carrageenan-Based Compounds as Wound Healing Materials

Neamţu

Barbu

Negrea

et al. 2022

IJMS

View full text Add to dashboard Cite

The following review is focused on carrageenan, a heteroglycan-based substance that is a very significant wound healing biomaterial. Every biomaterial has advantages and weaknesses of its own, but these drawbacks are typically outweighed by combining the material in various ways with other substances. Carrageenans’ key benefits include their water solubility, which enables them to keep the wound and periwound damp and absorb the wound exudate. They have low cytotoxicity, antimicrobial and antioxidant qualities, do not stick to the wound bed, and hence do not cause pain when removed from the wounded region. When combined with other materials, they can aid in hemostasis. This review emphasizes the advantages of using carrageenan for wound healing, including the use of several mixes that improve its properties.

show abstract

An Up-to-Date Review of Biomaterials Application in Wound Management

Cited by 70 publications

References 143 publications

rhEGF-Loaded Hydrogel in the Treatment of Chronic Wounds in Patients with Diabetes: Clinical Cases

rhEGF-Loaded Hydrogel in the Treatment of Chronic Wounds in Patients with Diabetes: Clinical Cases

Bacterial Cellulose and Its Applications

Carrageenan-Based Compounds as Wound Healing Materials

Contact Info

Product

Resources

About