An unusually fulminant case of encephalomyelitis in an 80 year old

Kyle, Kevin; Martinez‐Lage, Maria; Lang‐Orsini, Melanie; Venna, Nagagopal

doi:10.1016/j.nerep.2022.100102

Cited by 3 publications

(15 citation statements)

References 9 publications

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“…Another 11 records were identified from citation ( n = 1) or Google Scholar searches ( n = 10) and were also included. Finally, 31 articles met the eligibility criteria 15,24–53 and were included in the present systematic review (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The 31 included studies consisted of 24 case reports 15,24–26,28,29,31–34,36,37,39–41,43–50,53 and seven case series 27,30,35,38,42,51,52 (Table 1). In addition, 19 studies were published in 2022 15,36–53 and 12 were published in 2021 24–35 . Eight studies were conducted in the United States, 30,31,33,36,38,45,48,50 four in Italy, 26,34,49,51 three in Taiwan, 41,44,54 two in Qatar, 24,37 and 18 in other countries.…”

Section: Resultsmentioning

confidence: 99%

“…Of all 36 patients, 22 patients had adverse events after being vaccinated with the first dose and 14 after the second dose (Table 1). The majority of the patients fully or partially recovered, except for one case who died during the management process due to an undefined reason 45 . Polymerase chain reaction (PCR) tests were conducted for the majority of the included cases, all yielding negative results.…”

Section: Resultsmentioning

confidence: 99%

“…One of the reported EEGs was normal, 35 eight reported generalised slowing, 26,31,38,39,41,44–46,52 and two reported non‐convulsive focal status epilepticus 25,53 . There were also: two reports of nonspecific diffuse cerebral dysfunction, which were nonspecific and without evidence of seizures or epileptiform discharges 31,36 and with features of encephalopathy, that were suggestive of acute encephalopathy 24 ; moderate slowing of the cerebral background with no evidence of epileptiform discharges 25 ; left frontotemporal epileptiform discharges with severe post‐ictal encephalitic changes 37 ; epileptiform waves 40 ; continuous diffuse slowing in the theta and delta ranges 41 ; bitemporal focal slowing with admixed sharp waves that were more prominent on the right and intermittent background slowing in the theta range 42 ; focal slowing and epileptiform discharges over the right occipital projections 28 ; intermittent focal slow waves in the right frontocentral to parietal regions 54 ; epileptiform discharges and diffuse background slowing with intermittent low to moderate voltage sharp transients in the right frontotemporal region 44 ; focal polymorphic delta slowing 27 ; regional sharp‐waves in the left frontal area on a normal background 29 ; focal epileptiform discharges over the left posterior quadrant and diffuse delta‐theta slowing of the background 45 ; diffuse background slowing suggestive of encephalopathy, along with low voltage EEG and bilateral spikes and slow wave discharges in the frontocentral regions 46 ; intermittent right posterior slowing without epileptiform activity 48 ; diffuse triphasic waves with diffuse theta and delta slowing and no posterior dominant rhythm 49 ; significant generalised background slowing in the left hemisphere with sharp waves 52 ; increased widespread slow waves accompanied by sharp waves 52 ; and intermittent slowing in the delta range, predominantly over the fronto‐temporal regions 56 (Table 1 and Table ).…”

Section: Resultsmentioning

confidence: 99%

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Electroencephalographic findings post‐COVID‐19 vaccination: A systematic review of case reports and case series

Fazlollahi,

Zahmatyar,

Shamekh

et al. 2023

Reviews in Medical Virology

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A number of different neurological complications have been reported following vaccination against the coronavirus disease 2019 (COVID‐19). Electroencephalogram (EEG) is one of the modalities used to evaluate the neurological complications of diseases. The aim of the present study was to identify the EEG changes in participants vaccinated against COVID‐19. PubMed, Scopus, Web of Science, medRxiv, and Google Scholar were searched up to 1 September 2022, with terms related to COVID‐19 vaccines, EEG, neurological signs/symptoms, or neurological disorders. All case reports and case series were included if the participants had received at least one dose of a COVID‐19 vaccine and a post vaccination EEG report was also reported. We used the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for case reports and case series to appraise the methodological quality of the included studies. Thirty‐one studies were included, which were comprised of 24 case reports and seven case series and a total of 36 participants. Generalised slowing and non‐convulsive focal status epilepticus were the most common EEG findings post‐COVID‐19 vaccination. The most frequent symptoms were headache, fatigue, generalised weakness, and vomiting. In addition, the most common signs were encephalopathy, post‐ictal phases, and confusion. Encephalitis, acute disseminated encephalomyelitis, and post‐vaccinal encephalopathy were the most commonly diagnosed adverse events. Furthermore, most of the imaging studies appeared normal. The EEG reports mainly showed background slowing and epileptiform discharges, encephalitis, encephalopathies, and demyelinating disorders. Future studies with larger samples and more vaccine types may help to further unravel the potential neurological effects of COVID‐19 vaccinations on recipients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Electroencephalographic findings post‐COVID‐19 vaccination: A systematic review of case reports and case series

Fazlollahi,

Zahmatyar,

Shamekh

et al. 2023

Reviews in Medical Virology

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Tozinameran

2024

Reactions Weekly

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Cardiac and Neurological Complications Post COVID-19 Vaccination: A Systematic Review of Case Reports and Case Series

Lee,

Yap,

Amin-Nordin

et al. 2024

Vaccines

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Following mass vaccinations for the control of the COVID-19 epidemic, a spectrum of cardiac and neurological disorders was reported among vaccinated individuals. This study examined the range of complications documented and factors related to their occurrence. Three electronic databases were searched for case reports and case series with descriptions of cardiac and/or neurological complications in COVID-19 vaccine recipients. A total of 698 vaccinees were included in this review, of which 259 (37.1%) had cardiac and 439 (62.9%) had neurological complications. Inflammatory conditions were the commonest among the cardiac complications; while polyneuropathy, demyelinating diseases and cerebrovascular disorders were the more common neurological complications. The mean age of those with cardiac complications (33.8 years) was much younger than those with neurological complications (49.7 years). There was no notable difference in the gender distribution between these two groups of vaccine recipients. mRNA vaccines (all brands) were associated with almost 90.0% of the cardiac complications, whereas viral vector vaccines were associated with slightly over half (52.6%) of the neurological complications. With regard to the dose, cardiac complications were more common after the second (69.1%), whereas neurological complications were more common after the first dose (63.6%). The majority of the cases had an uncomplicated clinical course. Nevertheless, 5.9% of cases with neurological complications and 2.5% of those with cardiac complications were fatal, underscoring the significance of the consistent surveillance and vigilant monitoring of vaccinated individuals to mitigate these occurrences.

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An unusually fulminant case of encephalomyelitis in an 80 year old

Cited by 3 publications

References 9 publications

Electroencephalographic findings post‐COVID‐19 vaccination: A systematic review of case reports and case series

Electroencephalographic findings post‐COVID‐19 vaccination: A systematic review of case reports and case series

Tozinameran

Cardiac and Neurological Complications Post COVID-19 Vaccination: A Systematic Review of Case Reports and Case Series

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