“…The other northwestern molecular half consisted of a tetralone subunit linked to an isoquinoline part by a 5‴,8″-axis and by an oxygen bridge between C-1′′ and C-6′′′ (Figure 4A). NMR data evidencing such connections were identical to those already observed in the other, previously characterized cyclombandakamines, 11,13 among them joint HMBC correlations from H-7″, H-7‴, and H eq -4‴ to C-5″′, which indicated a 5′′′,8′′-coupling, and ROESY interactions between H-7′′ and both diastereotopic protons at C-4′′′ and between H-7′′′ and The connections between the two molecular halves, via the 6′,1″-axis and the C-2′′−O-5′−C-5′ oxygen bridge, to form an entire cyclombandakamine-type scaffold, were evident from HMBC cross-peaks between C-1′′ and both H b -3″ and H-6′ and from the chemical shift of C-2′′ (δ C 92.4) indicating it to be an acetal, together with ROESY interactions between CH 3 -3‴, in the northwestern isoquinoline portion, and H-7′, H-7, OCH 3 -8, and CH 3 -1 in the southeastern naphthylisoquinoline moiety (Figure 4A). Hence, the second isolated dimer, compound 8, was constitutionally different from its isomeric and co-occurring congener 3 only by its N-methyl pattern.…”