An Unusual Type of Pemphigus

Senear, Francis Eugene; Usher, B.

doi:10.1001/archderm.1926.02370180026002

Cited by 110 publications

(6 citation statements)

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“…The nature of the "lupus-band phenomenon" in PE was disclosed by Oktarina et al [13]. The granular BMZ depositions located below the lamina densa consist of IgG, complement, and the shed desmoglein 1 ectodomain.…”

Section: Facts and Figuresmentioning

confidence: 94%

“…Half desmosomes and desmosomes should be distinguished from hemidesmosomes which are cell-matrix junctions and are explained in Chap. 13.…”

Section: Learning Objectivesmentioning

confidence: 99%

“…Pemphigus erythematosus (PE) was first described in 1926 by Senear and Usher [13] as a condition with a lupus-like butterfly rash or severe seborrheic dermatitis, which they suggested was a combination of pemphigus vulgaris and lupus erythematosus (LE). Investigatingthe differences between pemphigus vulgaris and PF, it became clear that PE is rather an early form of PF.…”

Section: Pemphigus Erythematosus Introductionmentioning

confidence: 99%

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Indirect Immunofluorescence Microscopy

Diercks

Pas

2022

Autoimmune Bullous Diseases

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translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Section: Facts and Figuresmentioning

confidence: 94%

“…Half desmosomes and desmosomes should be distinguished from hemidesmosomes which are cell-matrix junctions and are explained in Chap. 13.…”

Section: Learning Objectivesmentioning

confidence: 99%

Section: Pemphigus Erythematosus Introductionmentioning

confidence: 99%

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Indirect Immunofluorescence Microscopy

Diercks

Pas

2022

Autoimmune Bullous Diseases

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“…Pemphigus erythematosus (PE) was described for the first time in 1926 by Senear and Usher as a syndrome with features of both lupus erythematosus and pemphigus. 1 Since the original reports there has been a debate on whether PE is an overlap syndrome or simply a localized variant of pemphigus foliaceus. In fact, clinical and histological findings are similar to those of pemphigus foliaceus.…”

Section: Introductionmentioning

confidence: 99%

Pemphigus erythematosus relapse associated with atorvastatin intake

Schiavo¹,

Puca²,

Romano³

et al. 2014

DDDT

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Statins, also known as 3-hydroxy-3-methylglutaril-CoA reductase inhibitors, are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Although they are generally considered safe, some serious adverse effects, such as myositis, myopathy, and rhabdomyolysis can rarely occur. Furthermore, recent data from long-term follow-up on patients who have been taking statins for a long period of time suggest that prolonged exposure to statins may trigger autoimmune reactions. The exact mechanism of statin-induced autoimmune reactions is unclear. Statins, as proapoptotic agents, release nuclear antigen into the circulation and may induce the production of pathogenic autoantibodies. Herein we report the case of a 70 year-old man who developed a relapse of pemphigus erythematosus, a syndrome with features of both lupus erythematosus and pemphigus, after atorvastatin intake.

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“…Many observers now believe that pemphigus erythematosus is a localized form of pemphigus foliaceus. However, there are still many others who think that it is a variety of pemphigus vulgaris and even¬ tually progresses into the common form of pemphigus.3'5 A case of pemphigus erythematosus is re¬ ported below for the following reasons: (1) to show the age of the patient, which was less than 6 years at onset, (2) to show the effects of Jamarsan paint and a concentrat¬ ed topical fluocinolone acetonide prepara-Erythematosus is the same term in Latin as erythematodes, the Greek form of an adjective meaning reddened. tion, and (3) to show the apparent long-term control of the disease process with systemic tetracyclines.…”

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confidence: 99%

Pemphigus Erythematosus

Petratos¹,

Andrade²

1967

Am J Dis Child

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RETROSPECTIVELY, that form of pemphigus which has come to be known by the eponym of Senear-Usher syndrome or more formally as pemphigus erythematosus,* was first presented by Ormsby and Mitchell1 as a case for diagnosis at a meeting of the Chicago Dermatological Society in 1921. In 1925, before the American Dermatological Association, Senear and Usher analyzed 11 similar cases and described the salient features of the condition which has since borne their names.2 Their original description was of a dermatosis involving chiefly or exclusively the head and trunk. The clinical picture embraced features of both lupus erythematosus and pemphigus. The lesions were present on the trunk, usually in the areas involved in seborrheic dermatitis; they were flaccid bullae that ruptured readily and, on their sites, developed scales and crusts that were thick and dry or greasy.Since this original description, many articles have been written about the clinical and histologic picture, the nosologic features, and treatment of pemphigus erythem¬ atosus. Many observers now believe that pemphigus erythematosus is a localized form of pemphigus foliaceus. However, there are still many others who think that it is a variety of pemphigus vulgaris and even¬ tually progresses into the common form of pemphigus.3'5 A case of pemphigus erythematosus is re¬ ported below for the following reasons: (1) to show the age of the patient, which was less than 6 years at onset, (2) to show the effects of Jamarsan paint and a concentrat¬ ed topical fluocinolone acetonide prepara-The patient was a 6-year-old, white Jewish girl when first seen 14 months ago. According to her mother she began to develop "pimples" on the back several months before. The lesions were thought to be insect bites. When they did not disappear within a period of several weeks, the mother consulted several physicians who prescribed topical steroids and antibiotics. No benefit resulted and the lesions continued to appear sporadically and randomly on the back, chest, scalp, and extremities (Fig 1).When the patient was hospitalized one month later, on Feb 25, 1965, examination showed a widespread eruption on the neck, back, face, chest, and extremities of 1-to 6-cm sized, irreg¬ ularly bordered, erythematous, slightly moist, crusted plaques. A positive Nikolsky sign was present. The scalp was completely covered with thick, whitish, adherent scales (Fig 2). There were no lesions on the mucous membranes.The biopsy of an early vesicular lesion showed an area of intra-epidermal cleavage located underneath the granular layer and forming a flaccid bulla. It contained groups of polymorphonuclear leukocytes and very few isolated or grouped acantholytic cells. The underlying layers of the epidermis showed in¬ tercellular edema. The upper dermis showed a mild perivascular inflammatory infiltrate formed by lymphocytes, histiocytes, and a few polymorphonuclear leukocytes. The microscopic picture was compatible with signs of pemphi¬ gus erythematosus (Fig 3).The biopsy of an older crusted lesion sh...

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An Unusual Type of Pemphigus

Cited by 110 publications

References 0 publications

Indirect Immunofluorescence Microscopy

Indirect Immunofluorescence Microscopy

Pemphigus erythematosus relapse associated with atorvastatin intake

Pemphigus Erythematosus

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