An unusual translocation in a case of Mongolism

Partial trisomy in a child with features suggesting mongolism.

“…(b) Sporadic cases with a large acrocentric chromosome replacing one G chromosome have been found in mongol patients (Zellweger, Mikamo, and Abbo, 1963;Lejeune et al, 1965;Robertson, Mellon, and Stewart, 1965;Richards, Stewart, and Sylvester, 1965). The interpretation of Lejeune et al seems to be right.…”

Tandem Translocation of No. 21 Chromosome in a Patient with Atypical Down Syndrome

“…A., Oct. 13, 1980) Since a case of the extra G chromosome translocation to the other G chromosome was described in Down syndrome by Zellweger et al (1963) , similar cases have been reported by many authors (Lejeune et al 1965 ;Richards et al 1965 ;Kadotani et al 1970;Vogel et al: 1970 ;Garson et al 1970 ;Sachdeva et al 1971;Vogel 1972 ;Bartsch-Sandhoff and Schade 1973 ;Aula et al 1973 ;Schuh et al 1974;Niebuhr 1974;Wahlstrom 1976;Williams et at. 1975;Couturier et al 1976;Hagemeijer et al 1977).…”

A 21/21 tandem translocation with satellites on both long and short arms

“…Familial translocations have been reported by Soudek, Laxova, and Addmek (1968) and Cohen and Davidson (1967). A few reports of non-familial G/G tandem translocations have also appeared (Warkany and Soukup, 1963;Zellweger, Mikamo, and Abbo, 1963;Lejeune et al, 1965). Sachdeva, Wodnicki, and Smith (1971) and Vogel (1972) found a G/G tandem translocation chromosome with satellites on both the long and short arms, and identified it as a 21/21 translocation by differential staining.…”