An Unusual Round Cell Tumor of the Tibia with Granular Cells

Schofield, Deborah E.; Conrad, Ernest U.; Liddell, Robert M.; Yunis, Eduardo J.

doi:10.1097/00000478-199505000-00012

Cited by 9 publications

(6 citation statements)

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“…A similar tumour was recently reported by Schofield et al [17]. Among the seven tumours, including ours, there were four bone [9,12,14,17] and three juxta-or periosteal lesions [9,15]. The chief complaint was pain for five patients, and two complained of a mass.…”

Section: Discussionsupporting

confidence: 87%

“…This unusual tumour is very similar to neoplasms variously referred to as ''malignant tumour of humerus with features of adamantinoma and Ewing's sarcoma'' by Meister et al [14], Ewing-like adamantinoma [12], juxtacortical adamantinoma (simulating Ewing tumour) by Ishida et al [8,9], and ''adamantinoma of the pretibial soft tissue'' by Mills and Rosai [15]. A similar tumour was recently reported by Schofield et al [17]. Among the seven tumours, including ours, there were four bone [9,12,14,17] and three juxta-or periosteal lesions [9,15].…”

Section: Discussionsupporting

confidence: 74%

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Periosteal Ewing-like adamantinoma

Fukunaga

Ushigome

1998

Virchows Archiv

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We report a Ewing-like adamantinoma of the periosteal region of the right tibia in a 15-year-old boy. The tumour was well demarcated but unencapsulated and showed cortical bone erosion. Histologically, the neoplastic cells were arranged in trabecular and cord-like patterns with fibrous, hyalinized, and myxoid stroma. Cellular atypia was mild, and mitotic figures were rarely seen. Many tumour cells expressed wide keratin, epithelial membrane antigen, leu 7, synaptophysin, Ewing's sarcoma-related antigen O13, and some were positive for neuron-specific antigen, vimentin, and CD68. The tumour was negative for S-100 protein, desmin, alpha-smooth muscle actin, and muscle-specific actin. Flow cytometric analysis showed that the tumour was aneuploid. After wide excision the patient has been well for the 16 months since diagnosis.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 74%

Periosteal Ewing-like adamantinoma

Fukunaga

Ushigome

1998

Virchows Archiv

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“…Interestingly, the long list of tumors in which this change has been documented does not include skeletal chondrosarcoma or, for that matter, any other type of primary bone tumors. Our review of the literature disclosed only 2 primary neoplasms of bone that were interpreted as pure granular cell tumors [38,39].…”

Section: Discussionmentioning

confidence: 99%

Well-differentiated Chondrosarcoma of the Humerus with Prominent Granular Cell Component: A Hitherto Unreported Occurrence

et al. 2006

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We report the case of a well-differentiated chondrosarcoma of the proximal humerus in a 60-year-old man that featured a prominent component of granular cells, the granules being shown by electron microscopy to be lysosomal. Although secondary granular cell changes have been described in a large variety of tumor types, this is, to the best of our knowledge, the first documentation of this phenomenon in a skeletal chondrosarcoma.

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“…Subsequently, it transforms into an organized pneumonia and, eventually, into an inflammatory myofibroblastic tumour. In support of this hypothesis, production of IL-6 mRNA and protein by tumour cells in IPT has been reported in some cases [8,9]. Yet, according to another hypothesis, some plasma cell granulomas represent slow-growing mesenchymal tumours with secondary inflammatory changes.…”

Section: Introductionmentioning

confidence: 86%

Macrophage activation syndrome in a patient with pulmonary inflammatory myofibroblastic tumour

Kuppe

Westphal

Bücher

et al. 2012

All Asth Clin Immun

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We describe for the first time a case of macrophage activation syndrome (MAS) in a patient with a history of inflammatory myofibroblastic tumour (inflammatory pseudotumour, IPT) of the lung and thoracic spine. The patient was admitted to the intensive care unit with a history of prolonged remitting fever, hepatosplenomegaly, bilaterally enlarged thoracic lymph nodes and an acute severe inflammatory response syndrome (SIRS). Up-regulated cytokine production (e.g. IL-1ß and IL-6), increased levels of ferritin and circulating soluble interleukin-2 receptor (sIL-2R, sCD25) led to the differential diagnosis of MAS. Bone marrow aspiration, the main tool for a definite diagnosis, revealed macrophages phagocytosing haematopoietic cells. Immunosuppressive therapy with corticosteroids and cyclosporine was an effective treatment in this patient.

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An Unusual Round Cell Tumor of the Tibia with Granular Cells

Cited by 9 publications

References 0 publications

Periosteal Ewing-like adamantinoma

Periosteal Ewing-like adamantinoma

Well-differentiated Chondrosarcoma of the Humerus with Prominent Granular Cell Component: A Hitherto Unreported Occurrence

Macrophage activation syndrome in a patient with pulmonary inflammatory myofibroblastic tumour

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