An Unusual Presentation of Tumor Lysis Syndrome in a Patient with Advanced Gastric Adenocarcinoma: Case Report and Literature Review

Vodopivec, Danica M.; Rubio, Jose E.; Fornoni, Alessia; Lenz, Oliver

doi:10.1155/2012/468452

Cited by 36 publications

(52 citation statements)

References 87 publications

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“…TLS mortality rate in hematological malignancies was found as 36.3% and mortality rate in solid tumors was found as 42.8%. 6 . In our study, common solid metastases are present in all solid tumors.…”

Section: Resultsmentioning

confidence: 99%

Assessment of tumor lysis syndrome cases

Hüzmelí¹

2019

Cumhuriyet Medical Journal

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Tumor lysis syndrome (TLS) is a clinical picture that occurs with the rapid destruction of tumor cells and with life-threatening metabolic disorders. The aim of our study is to evaluate the etiologic causes, diagnosis and treatment of TLS cases. Method: The study was conducted between January 2015 and December 2017 in Kahramanmaras Necip Fazıl city Hospital. A total of 32 patients diagnosed with TLS were included in the study. Laboratory values of patients were scanned (blood urea nitrogen, creatinine, potassium, phosphorus, calcium, serum uric acid, lactate dehydrogenase) and diagnoses, chemotherapy and treatments were noted. Results: Of the 32 patients who were included in the study, 17 were male and 15 were female. The average age of the patients was found as 62,06 ± 12,10 (35-86) years. Hematologic malignancy was detected in the etiology of 11 of the TLS cases and solid tumor was detected in 21 of the TLS cases. A total of 12 (37.5%) patients had spontaneous TLS (5 in haematological malignancy and 7 in solid tumor). Hyperpotassaemia 50%, hypocalcaemia 46.9%, hyperphosphatemia, hyperuricemia and acute kidney damage was present in all patients. Mortality rate was found as 40.6%. Conclusions: In our study, spontaneous TLS was detected at a high rate. In addition, the mortality rate was also high. Early diagnosis and urgent treatment should be planned to avoid mortalities.

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Section: Resultsmentioning

confidence: 99%

Assessment of tumor lysis syndrome cases

Hüzmelí¹

2019

Cumhuriyet Medical Journal

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“…Concerning TLS in solid tumours, ‘bulky disease’ is defined as: (1) abdominal tumour mass greater than 10 cm, either the primary tumour, retroperitoneal nodes or single liver metastasis or (2) multiple liver metastases with two bigger than 5 cm 13. Also ‘extensive metastases’ are defined as producing organ enlargement 24. Known pretreatment risk factors for the development of TLS are high LDH, uric acid, azotaemia and creatinine 6.…”

Section: Discussionmentioning

confidence: 99%

Management of tumour lysis syndrome during first-line palliative chemotherapy for high-volume colorectal cancer

2018

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Tumour lysis syndrome (TLS) is a rare oncological emergency in solid tumours. Because it is associated with bad short-term prognosis, early recognition and treatment are mandatory. This case refers to a middle-aged woman who presented with stage IV colon cancer, with massive hepatic involvement. After three cycles of first-line FOLFOX (folinic acid, 5-fluorouracil and oxaliplatin), she developed acute kidney injury and hyperkalaemia that did not respond to standard measures. High suspicion of TLS prompted further corroborating investigations and early intensive care unit admission. With vigorous hydration and allopurinol, TLS completely resolved and the patient was discharged. Prophylaxis of subsequent TLS recurrence was complicated by biopsy-proven neutrophilic vasculitis secondary to allopurinol. Prevention of TLS with hydration and rasburicase was performed prior to each subsequent cycle of chemotherapy. This case report is intended to highlight risk factors for TLS in solid tumours and focus on treatment and secondary prophylaxis of TLS.

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“…Spontaneous TLS has been described in solid tumors and hematological tumors [6, 7]. Saravu et al reported a case having MM with spontaneous TLS, following a compression fracture of the L2 vertebrae.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of rasburicase starts within 4 h and uric acid normalized within 3-4 days. In patients with a prior history of glucose-6-phosphate dehydrogenase, rasburicase is contraindicated and allopurinol should be utilized instead of rasburicase [6, 12]. …”

Section: Discussionmentioning

confidence: 99%

Spontaneous Tumour Lysis Syndrome in a Multiple Myeloma

Hüzmelí

Eliaçık

Sağlam

et al. 2016

Case Reports in Medicine

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The tumor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur in consequence of the release of intracellular contents following lysis of tumor cells. TLS occurs spontaneously or after chemotherapy. Spontaneous TLS is uncommon occurrence in multiple myeloma (MM). We define a case of a 70-year-old woman patient who was found to have MM with spontaneous TLS, following a compression fracture of the T-12 vertebrae. While serum uric acid and phosphorous levels were high, low calcium levels were identified. There were also acute kidney injury and metabolic acidosis. Upon the diagnosis of TLS, she was treated with hydration, allopurinol, sodium bicarbonate, and calcium gluconate. The improvement of her laboratory data was observed. We submitted this case in order to draw attention to the presentation of MM with spontaneous TLS.

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An Unusual Presentation of Tumor Lysis Syndrome in a Patient with Advanced Gastric Adenocarcinoma: Case Report and Literature Review

Cited by 36 publications

References 87 publications

Assessment of tumor lysis syndrome cases

Assessment of tumor lysis syndrome cases

Management of tumour lysis syndrome during first-line palliative chemotherapy for high-volume colorectal cancer

Spontaneous Tumour Lysis Syndrome in a Multiple Myeloma

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