An Unusual Presentation of HTLV-Associated Adult T-Cell Lymphoma/Leukemia – An Eye That Said It “A (T) LL”

Bryne, Sharel Mendonca; Basavaiah, Sridevi Hanaganahalli; Pinto, Amanda Christina; Bhat, Guruprasad; Upadyaya, Krishnaraj; Thahir, Muhammed

doi:10.1080/07357907.2020.1728298

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Acute Versus Mature T-cell Neoplasm?1

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2022

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“…While distinguishing between T-lymphoblastic leukemia (T-ALL) and mature T-cell neoplasms is usually very straightforward with the presence of immature markers such as CD1a, CD34, and TdT in the former, there have been unusual cases of T-prolymphocytic leukemia, T-PLL seen with lack of surface CD3 and CD45 that can make the diagnosis more difficult ( 26 , 27 ). Similarly, there have been reports of mature T-cell neoplasms aberrantly expressing immature markers, such as CD1a ( 28 , 29 ).…”

Section: Acute Versus Mature T-cell Neoplasm?mentioning

confidence: 87%

Mature T-Cell leukemias: Challenges in Diagnosis

2022

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T-cell clones can frequently be identified in peripheral blood. It can be difficult to appreciate whether these are benign and transient or whether they signify a clonal disorder. We review factors that aid in understanding the relevance of T-cell clones. Conversely, obvious pathological T-cell clones can be detected in blood, but there is uncertainty in how to categorize this clonal T cell population, thus, we adopt a multidisciplinary review of the clinical features, diagnostic material and radiology before making the diagnosis. In this review we shall discuss some of these challenges faced when diagnosing mature T-cell leukemias.

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