An unusual onset of pediatric acute lymphoblastic leukemia

Brillantino, Carmela; Rossi, Eugenio; Bifano, Delfina; Minelli, Rocco; Tamasi, Sonia; Mamone, Rosanna; Bignardi, Elio; Zeccolini, Raffaele; Zeccolini, Massimo; Vallone, Gianfranco

doi:10.1007/s40477-020-00461-y

Cited by 19 publications

(4 citation statements)

References 15 publications

(58 reference statements)

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“…Acute lymphoblastic leukemia (ALL), which affects 80–90 children per million annually in Italy ( 28 ), accounts for ~25% of childhood cancer deaths, representing the most common malignancy in children ( 29 ). The expression and function of Sema4D is still unclear in ALL, and the aim of the present study was to investigate the expression level of Sema4D in pediatric ALL and its potential association with ALL development.…”

Section: Introductionmentioning

confidence: 99%

Semaphorin 4D is a potential biomarker in pediatric leukemia and promotes leukemogenesis by activating PI3K/AKT and ERK signaling pathways

et al. 2021

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Semaphorin 4D (Sema4D) is highly expressed in a variety of tumors and is associated with high invasion, poor prognosis and poor therapeutic response. However, the expression and role of Sema4D in leukemia remains unclear. The present study investigated the expression of Sema4D in pediatric leukemia and its effects in leukemia cells. The results demonstrated that Sema4D protein was highly expressed in peripheral blood mononuclear cells of patients with pediatric leukemia, and high levels of soluble Sema4D were also observed in the plasma of these patients. Sema4D knockdown induced cell cycle arrest in G 0 /G 1 phase, inhibited proliferation and promoted apoptosis in BALL-1 cells, while Sema4D overexpression exhibited the opposite effect. In Jurkat cells, Sema4D knockdown inhibited proliferation and promoted apoptosis, while Sema4D overexpression decreased the abundance of the cells in the G 0 /G 1 phase of the cell cycle and promoted proliferation. Sema4D overexpression also increased the migratory capacity of Jurkat cells and the invasive capacity of BALL-1 cells. The phosphorylation level of PI3K was decreased in both Sema4D knocked-down Jurkat and BALL-1 cells, and the phosphorylation level of ERK was decreased in Sema4D knocked-down BALL-1 cells. The phosphorylation levels of PI3K, ERK and AKT were elevated in patients with pediatric leukemia, and were correlated to the increased Sema4D expression. Sema4D overexpression was associated with a shorter overall survival in patients with acute myeloid leukemia. Overall, the results of the present study indicated that Sema4D serves an important role in leukemia development by activating PI3K/AKT and ERK signaling, and it may be used as a potential target for the diagnosis and treatment of leukemia.

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Section: Introductionmentioning

confidence: 99%

Semaphorin 4D is a potential biomarker in pediatric leukemia and promotes leukemogenesis by activating PI3K/AKT and ERK signaling pathways

et al. 2021

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“…Unlike cases of childhood malignancy or empyema, axial imaging by MRI or human tissue biopsy will almost never be available to validate lung ultrasound findings [ 27 – 31 ].…”

Section: Discussionmentioning

confidence: 99%

Validating a bovine model for lung ultrasound of bronchiolitis

et al. 2022

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Purpose Bronchiolitis is a very common acute lung disease in infants caused commonly by respiratory syncytial virus (RSV). Point-of-care lung ultrasound is increasingly used in clinical care but proof that ultrasound reflects histological disease is lacking. Bovine calves are a good model for RSV bronchiolitis. We answered the following two questions: (1) does point-of-care lung ultrasound reflect lung pathology at the histological level in a bovine calf model of bronchiolitis? and (2) are point-of-care lung ultrasound images in human infants similar to those obtained in calves? Methods We experimentally infected 24 five to six-week-old bovine calves with RSV and compared six window lung ultrasound with lung histology10 days after inoculation. The calves were treated with antivirals and antipyretics leading to variable severity of illness. We used canonical discriminant analysis to determine if abnormal lung ultrasound findings reflected different histological findings. We compared the ultrasounds obtained from the calves with ultrasounds obtained from 10 human infants who were diagnosed clinically with bronchiolitis. Results Canonical discriminant analysis generally demonstrated good class separation based on the maximal severity of ultrasound finding in each acoustic window. Lung ultrasound performed poorly at detecting bronchopneumonia. Bovine ultrasounds looked similar to human infant lung ultrasounds. Conclusion Point-of-care lung ultrasound abnormalities reflect lung pathology at the histological level in a bovine calf model of bronchiolitis. Point-of-care lung ultrasound images in human infants are similar to those obtained in calves.

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“…In our case, we first ruled out that it was testicular torsion. We did not find it necessary to detect tumor markers because the lesion on US was not highly suggestive of a malignant lesion [20,21]; it had no signs of vascularization at color Doppler US as we would expect in a solid mass, and it was reduced in size after 2 weeks.…”

Section: Discussionmentioning

confidence: 99%

An unusual location of hand, foot and mouth disease

et al. 2021

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Hand, foot, and mouth disease (HFMD) is a childhood febrile disease. Oral lesions and papulovesicular lesions on the hands and feet are the clinical signs of the disease. In our case, a 17-year-old boy presented to the emergency department, where he was diagnosed with HFMD. After 6 days, he felt intense pain in his right testicle, and therefore an ultrasound (US) examination was performed. US detected a hypoechoic mass-like area in the right testis. Viral etiology was suspected, and no therapy was prescribed. After a little more than 3 months, US examination showed a reduced lesion size. Viral epididymo-orchitis should be suspected in young men with a recent history of HFMD and testicular pain.

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An unusual onset of pediatric acute lymphoblastic leukemia

Cited by 19 publications

References 15 publications

Semaphorin 4D is a potential biomarker in pediatric leukemia and promotes leukemogenesis by activating PI3K/AKT and ERK signaling pathways

Semaphorin 4D is a potential biomarker in pediatric leukemia and promotes leukemogenesis by activating PI3K/AKT and ERK signaling pathways

Validating a bovine model for lung ultrasound of bronchiolitis

An unusual location of hand, foot and mouth disease

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