An Unusual Occurrence of Multiple Metachronous and Synchronous Primary Cancers in a Female Patient

Torina, Tyler B.; Hudspeth, Emily L.; Chun, Joon Min; Zaloga, William; Alderink, Carlisle; Abdeen, Yazan

doi:10.1155/2020/5691732

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…3 Malignancies that develop within 6 months are classified as synchronous, whereas those appearing after 6 months are considered metachronous. 3,4 Although squamous cell carcinoma and adenocarcinoma are the 2 most common types of esophageal cancer globally, the presence of different histologic types of dual cancers in the same organ is an intriguing and rare clinical finding. 5 In our case report, a patient previously treated for EAC with only chemoradiation therapy later presented with signs and symptoms of esophageal cancer once more.…”

Section: Discussionmentioning

confidence: 99%

Metachronous Squamous Cell Carcinoma of the Esophagus After Resolution of Previous Adenocarcinoma

et al. 2023

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Esophageal cancer is the sixth leading cause of cancer-related death worldwide. Metachronous malignancies refer to multiple independent primary cancers diagnosed at least 6 months apart. The incidence of metachronous esophageal cancers with different histologic subtypes is extremely rare. This case presents an unprecedented occurrence of esophageal adenocarcinoma, followed by metachronous squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Metachronous Squamous Cell Carcinoma of the Esophagus After Resolution of Previous Adenocarcinoma

et al. 2023

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“…It has been suggested that patients diagnosed with one type of cancer have higher likelihood of developing another type of cancer compared to the general population[ 9 ]. Although the reason is yet to be identified, factors to be considered include more frequent screening methods, recent improvement of imaging modalities, exposure to radiotherapy and hormonal therapy, environmental factors, and genetic factors.…”

Section: Discussionmentioning

confidence: 99%

Metachronous squamous cell carcinoma of pancreas and stomach in an elderly female patient: A case report

Kim¹,

Kang²,

Lee³

et al. 2021

WJCC

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BACKGROUND Squamous cell carcinoma (SCC) in pancreas and stomach is a rare histologic subtype with aggressive behavior, poor prognosis, and no standardized therapy. Pancreatic SCC or gastric SCC has been previously reported. However, case of SCC occurring in both the pancreas and the stomach has not been reported yet. CASE SUMMARY A 75-year-old female with prior history of hypertension and diabetes mellitus visited our hospital with complaint of abdominal pain that started three months ago. Computed tomography (CT) scan of the abdomen showed 3.3 cm mass at the distal pancreas. She received surgical resection which was histologically found to be SCC of the pancreas with clear resection margins. After she was discharged, she no longer visited the hospital. Three years later, she was referred to our hospital after showing abnormal findings on a gastroscopy performed at another hospital. Gastroscopy revealed a single, 2cm sized, ill-defined irregular flat and hyperemic mass at high body. Histologic finding of the mass was SCC. CT scan and positive emission tomography CT showed metastatic lesions to the liver and the peritoneum. She received combination chemotherapy with capecitabine and oxaliplatin. However, she passed away 6 mo after diagnosis of gastric SCC. CONCLUSION To the best of our knowledge, this is the first case of metachronous SCC of stomach occurring after diagnosis of pancreatic SCC.

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Prognostic Factors Affecting Survival of Patients With Single Primary Breast Cancer vs Patients With Multiple Primary Cancers in Lifetime, One of Which is Breast Cancer

Sanli,

Tekcan Sanli,

Altundag

et al. 2024

The American Surgeon™

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Purpose The aim of this study was to investigate the demographic and molecular characteristics, overall survival (OS), cancer-specific survival (CSS), and prognostic factors affecting the survival of patients with single primary breast cancer (SPBC) and patients with multiple primary cancers in their life time in which one of them is breast cancer (MPC). Methods Using data from SEER 17 Research Plus, patients with breast cancer diagnosed between 2010 and 2019 were included in this study. Race, marital status, laterality, tumor size, molecular subtype, grade, stage, radiotherapy-chemotherapy treatment, and surgery data were analyzed in the data obtained after excluding patients with missing values. Kaplan-Meier survival analysis was used for survival analysis, and Cox regression analysis was used to evaluate the prognostic factors. Results 573175 patients were included in the study. The mean age of MPC patients was significantly higher than SPBC patients (65.99 ± 12.68, 60.33 ± 13.47, P < .001, respectively). Patients with SPBC had significantly more hormone receptor (HR)-positive/Her2 positive, HR-negative/Her2-negative, and HR-negative/Her2-positive molecular subtypes; patients with MPC had more HR-positive/Her2-negative subtypes ( P < .001). Grade 3 tumor status, locoregional spread, and distant metastasis were significantly higher in SPBC patients ( P < .001). Overall survival and CSS rates were significantly higher in SPBC patients ( P < .001). In MPC patients, overall hazard ratio was 1.631 times higher than SPBC, and the cancer-specific hazard ratio was 1.096 times higher (95% CI [1.606-1.656], 95% CI [1.071-1.121], respectively). Conclusion Although patients with SPBC have worse prognostic tumor characteristics, OS and CSS rates are better than patients with MPC.

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An Unusual Occurrence of Multiple Metachronous and Synchronous Primary Cancers in a Female Patient

Cited by 4 publications

References 18 publications

Metachronous Squamous Cell Carcinoma of the Esophagus After Resolution of Previous Adenocarcinoma

Metachronous Squamous Cell Carcinoma of the Esophagus After Resolution of Previous Adenocarcinoma

Metachronous squamous cell carcinoma of pancreas and stomach in an elderly female patient: A case report

Prognostic Factors Affecting Survival of Patients With Single Primary Breast Cancer vs Patients With Multiple Primary Cancers in Lifetime, One of Which is Breast Cancer

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