An unusual glucomannan from Tornabenia intricata

Teixeira, Antônio Zenon Antunes; Iacomini, Marcello; Gorin, Philip A.J.

doi:10.1016/0031-9422(92)83708-7

Cited by 21 publications

(6 citation statements)

References 22 publications

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“…Although some polysaccharides from ascomycetous lichens are reported to be composed of galactofuranose, glucopyranose and mannopyranose residues [25, 27, 28, 32–37], little work about possible anti-malarial activity has been performed. Lentinan (1,3- β - d -glucan) has recently been investigated for its anti-malarial activity using the P. yoelii blood-stage infection model and found to possess prophylactic potential for the treatment of malaria via immunostimulation [9].…”

Section: Discussionmentioning

confidence: 99%

A Water‐Soluble Polysaccharide from the Fruit Bodies of Bulgaria inquinans (Fries) and Its Anti‐Malarial Activity

Han

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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A water-soluble polysaccharide (BIWS-4b) was purified from the fruit bodies of Bulgaria inquinans (Fries). It is composed of mannose (27.2%), glucose (15.5%) and galactose (57.3%). Its molecular weight was estimated to be 7.4 kDa (polydispersity index, Mw/Mn: 1.35). Structural analyses indicated that BIWS-4b mainly contains (1 → 6)-linked, (1 → 5)-linked and (1 → 5,6)-linked β-Galf units; (1 → 4)-linked and non-reducing terminal β-Glcp units; and (1 → 2)-linked, (1 → 6)-linked, (1 → 2,6)-linked and non-reducing terminal α-Manp units. When examined by the 4-day method and in a prophylactic assay in mice, BIWS-4b exhibited markedly suppressive activity against malaria while enhancing the activity of artesunate. Immunological tests indicated that BIWS-4b significantly enhanced macrophage phagocytosis and splenic lymphocyte proliferation in malaria-bearing mice and normal mice. The anti-malarial activity of BIWS-4b might be intermediated by enhancing immune competence and restoring artesunate-suppressed immune function. Thus, BIWS-4b is a potential adjuvant of anti-malaria drugs.

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Section: Discussionmentioning

confidence: 99%

A Water‐Soluble Polysaccharide from the Fruit Bodies of Bulgaria inquinans (Fries) and Its Anti‐Malarial Activity

Han

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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“…The α-configuration corresponds to the the isolichenan class and β to the lichenan one. The second group is heteropolysaccharidic branched-chain-containing galactose and mannose (galactomannan), where the most abundant feature bonds (1→6)- containing α- d -Man p ( 2 ) as the main chain and α- or β- d -Gal p , β- d -Gal f and α- d -Man p as side chains [14,15,16,17,18,19,20,21].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Chemistry and Biological Activity of Ramalina Lichenized Fungi

et al. 2015

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Lichens are a form of symbiont between a fungus and an alga or cyanobacterium, which contains a wide variety of organic compounds with certain secondary metabolite classes typical of these organisms. The Ramalina genus has approximately 246 species distributed around the World, of which in this review approximately 118 species with published chemical or biological activity studies of extracts or isolated compounds were cited. From the 153 mentioned compounds, only 27 passed were tested for biological activity, being usnic acid the most studied compound and the one showing the best results in almost all in vitro tests performed, although other compounds also presented excellent results as antimicrobial, antitumor and anti-inflammatory agents, among others. Extracts of several species also presented significant results in performed biological tests, demonstrating the potential that these organisms have, in particular, the gender Ramalina, to produce bioactive molecules that can be used as a model for the production of pharmaceuticals.

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“…It is noteworthy that similar glucomannans were found only in Tornabenia intricata (Teixeira et al, 1992) and Heterodermia obscurata (Pereira et al, 2010), two lichenized fungi of the family Physciaceae, to which P. kalbii belongs. Their glucomannans have minor structural differences, which could be typical of the species.…”

Section: Resultsmentioning

confidence: 97%