An unusual cytological presentation of solid pseudopapillary neoplasm of the pancreas mimicking adenoid cystic carcinoma: a case report and literature review

Higuchi, Yumiko; Kurihara, E.; Kato, Toshihiko; Oshima, Mieko; Endo, Fumiyasu; Sato, Fuminori; Kobatake, Tsutomu; Ijima, Masashi; Sugihara, Shiro; Tani, Noriyuki; Otake, Yosuke; Imai, Yasuo

doi:10.1007/s00428-023-03569-8

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…Still, there exist certain scenarios in which distinguishing SPN from other types of pancreatic cancers becomes challenging. Higuchi reported in a case report about SPN mimicking adenoid cystic tumors because of representing microcystic configurations with mucus [ 48 ]. When special features are present, such as predominant acinar units, squamoid nests, prominent central nucleoli, granular eosinophilic cytoplasm enclosing DPAS-positive zymogen granules, and positive immunochemistry results for trypsin, chymotrypsin, BCL10, and lipase, it is possible to confuse SPN and pancreatoblastoma [ 49 ].…”

Section: Pathological Features Of Spn: Origin Of Malignancymentioning

confidence: 99%

Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management

Lu,

Chen,

Zhang

2024

Discov Onc

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Solid pseudopapillary neoplasms (SPN) of the pancreas are presently recognized as low-grade malignant tumors that are frequently observed in young females. This tumor has a low incidence and is associated with an excellent prognosis following surgical resection. Typical SPNs primarily affect the pancreas and tend to have moderate or asymptomatic manifestations. Based on retrospective research, it is anticipated that patients with SPN can achieve disease-free survival, even in cases when metastasis is detected during inspection. However, the incidence of malignant SPN has been consistently underestimated, as evidenced by recent research findings. Malignancy of SPN primarily encompasses invasion and infiltration, metastasis, and recurrence after R0 resection. Imaging technologies such as Ultrasound, Computed Tomography, Magnetic Resonance Imaging, and Position Emission Tomography are capable of preliminarily identifying malignant SPN, which is primarily based on its invasive clinical features. Research on risk factors of malignant SPN revealed that larger tumor size, Ki-67 index, and several other parameters had significant correlations with invasive tumor behavior. Pathologic features of malignant SPNs overlay other pancreatic tumors, nevertheless they can provide valuable assistance in the process of diagnosis. Several confirmed specific pathologic biomarkers are related to its cellular origin, characteristic gene mutation, and cell proliferation. Considering the invasiveness of malignant SPN, it is imperative to enhance the comprehensiveness of its therapy. Tumor resection remains a suggested course of action in line with typical SPN, and additional lymph node dissection is seen as reasonable. Compared to benign SPNs, malignant SPNs have worse prognosis, underscoring the necessity of early identification and treatment in comprehensive medical centers to get improved clinical outcomes.

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Section: Pathological Features Of Spn: Origin Of Malignancymentioning

confidence: 99%