An Unusual Clinical Presentation of Immunoglobulin A Vasculitis in an Elderly Patient

Anokwute, Akudo U; Bakare, Olusegun; Ogbuji, Chukwunonye O; Arinze, Nkechi C

doi:10.7759/cureus.10946

Cited by 2 publications

(2 citation statements)

References 14 publications

(20 reference statements)

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“…Existing literature infrequently details instances of adult IgA vasculitis initially appearing as lower extremity edema, underscoring the importance for clinicians to maintain a comprehensive differential diagnosis when confronted with this symptom. A documented case report has described an elderly patient with bilateral lower extremity swelling and concurrent gastrointestinal symptoms, further indicating the varied presentation of IgA vasculitis [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Bilateral Lower Extremity Edema in the Elderly: Immunoglobulin A (IgA) Vasculitis

Yanagihara¹,

Nakagawa²,

Nishie³

et al. 2023

Cureus

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We report a case of a 74-year-old male who exhibited bilateral lower extremity edema over three days. Examination revealed no signs of heart, renal, or hepatic failure, and hypothyroidism was also ruled out. An outpatient regimen of 40 mg furosemide was initiated. At a 12-day follow-up, although the edema had improved, the patient had developed pain in both lower limbs, especially ankles, accompanied by numerous petechiae and erythemas, some of which had formed papules. Skin biopsy of the rash displayed leukocytoclastic vasculitis with immunoglobulin A (IgA) deposition within the vascular walls, leading to a diagnosis of IgA vasculitis. Given the rarity of IgA vasculitis in elderly patients and the broad spectrum of potential diagnoses related to bilateral lower extremity edema in this population, IgA vasculitis can be easily overlooked. While this case did not present with glomerulonephritis, regular renal function monitoring is recommended due to the prognostic implications of renal involvement in adult-onset IgA vasculitis.

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Section: Discussionmentioning

confidence: 99%

An Unusual Case of Bilateral Lower Extremity Edema in the Elderly: Immunoglobulin A (IgA) Vasculitis

Yanagihara¹,

Nakagawa²,

Nishie³

et al. 2023

Cureus

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“…Bilateral lower limb swelling, and foul-smelling wounds was an unusual cutaneous presentation of immunoglobulin A vasculitis (IgAV) in an elderly man. He had been treated with antibiotics as cellulitis before a skin biopsy revealed a picture consistent with IgA vasculitis [10].…”

Section: Antineutrophil Cytoplasmic Antibodyassociated Vasculitismentioning

confidence: 99%

Updates in cutaneous manifestations of systemic vasculitis

Elbendary

Abdel‐Halim

Ragab

2021

Current Opinion in Rheumatology

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Purpose of reviewThe main purpose of this review is to present newly reported cutaneous manifestations of systemic vasculitis, updates in investigations to verify systemic involvement in cases with cutaneous vasculitis and new therapeutic guidelines. The spectrum of COVID-19-related vasculitis is also covered. Recent findingsOnly a few reports highlighted new cutaneous presentations or associations with some systemic vasculitic entities. For example, the association of inflammatory disorders with Takayasu arteritis, the importance of considering Kawasaki disease in febrile children with erythema nodosum, the development of necrotic ulcers on fingers and toes in Behc ¸et's disease and the possible presence of polyarteritis nodosa-like pathological features in vulvar ulcers of Behc ¸et's disease. New attempts to classify cutaneous manifestations of giant cell arteritis (GCA) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and the diagnostic investigations for cutaneous vasculitis cases to verify systemic involvement are discussed. Treatment of systemic vasculitis with cutaneous vasculitis should be tailored according to disease status. A plethora of reports in the past 2 years focused on the broad spectrum of COVID-19 vasculitic manifestations.

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An Unusual Clinical Presentation of Immunoglobulin A Vasculitis in an Elderly Patient

Cited by 2 publications

References 14 publications

An Unusual Case of Bilateral Lower Extremity Edema in the Elderly: Immunoglobulin A (IgA) Vasculitis

An Unusual Case of Bilateral Lower Extremity Edema in the Elderly: Immunoglobulin A (IgA) Vasculitis

Updates in cutaneous manifestations of systemic vasculitis

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