An Unusual Circulating Anticoagulant in Systemic Lupus Erythematosus

Ramot, Bracha; Singer, Karl

doi:10.1159/000205123

Cited by 28 publications

(10 citation statements)

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“…Moreover, we have found that treat ment with immunosuppressive agents in patients with thrombocytopenia and inhibitor often leads to normalisation of the platelet count but does not influence the inhibitor activity. A prolongation of thrombin time was found in a number of cases [7,83,93,106,114,130,131]. The mechanism leading to this abnormality has not yet been studied.…”

Section: Mode and Site O F Actionmentioning

confidence: 99%

Acquired Inhibitors in Nonhemophilic Patients

Lechner¹

1974

Pathophysiol Haemos Thromb

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Section: Mode and Site O F Actionmentioning

confidence: 99%

Acquired Inhibitors in Nonhemophilic Patients

Lechner¹

1974

Pathophysiol Haemos Thromb

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“…The usual type of circulating anticoagulant found in SLE, interferes with the conversion of prothrombin to thrombin (2), and therefore the prothrombin time is abnormal. Occasionally, it has shown antithrombin activity (3,4) and only one case has been reported in which it behaved as an anti-thromboplastinogen (5). In other disease states related to SLE, such as penicillin sensitivity reactions, rheumatoid arthritis, pemphigus, etc., though rarely, anticoagulants interfering with thromboplastin formation have been reported (6).…”

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confidence: 99%

Unusual Circulating Anticoagulant in a Patient with Systemic Lupus Erythematosus

Sánchez-Medal¹,

Lisker²,

E³

1963

Acta Haematol

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“…This phenomenon is likely to be true in all inhibitory coagulation niechanisms whether physiological or pathological. The acquired coagulation disorders, due to the development of inhibitory mechanism, can be divided into three types: (a) circulating anticoagulants which interfere with bloodthroniboplastin formation (Hougie,195 5 ) ; (b) those anticoagulants which do not interfere with blood thromboplastin but interrupt the tissue-thromboplastin system with, in consequence, a prolongation of the one-stage clotting time (Frick, 1955;Ramot and Singer, 1956); and (c) a small number of cases in which the anticoagulant was probably heparin (Bell, 1951;Speer, Hill, Maloney and Roberts, 1955;Quick and Hussey, 1957).…”

Section: Discussionmentioning

confidence: 99%

An Atypical Circulating Thromboplastin Inhibitor

Douglas

1958

Br J Haematol

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ACQUIRED haemorrhagic diatheses due to the development of a circulating anticoagulant are well recognized. These circulating anticoagulants are thromboplastiii inhibitors; they cause a disturbance of blood coagulation by preventing the formation of blood thromboplastin, but not its action once formed.These conditions, in common with other disorders of blood thromboplastin, usually have a prolonged whole-blood clotting time, defective prothroinbin consumption and a normal one-stage 'prothrombin' time. The accepted diagnostic feature in such cases has been the property of a small addition of blood from the affected patient to prolong significantly the clotting time of normal blood. In the patient to be described the circulating anticoagulant was atypical. A small addition of blood from this patient did not significantly lengthen the clotting time of normal blood and it was able to shorten appreciably the clotting time in haemophilia and Christmas disease. CASE REPORTThe paticnt was a 33-year-old male, a seaman. He was admitted to the Royal Infirmary, Glasgow, in December 1955 as a case of haemorrhagic diathesis for investigation.In 1945 he first noticed vague generalized aches and pains. Subsequently there was stifiiess and discomfort in the back, difficulty in turning the head and pain in the chest when coughing or sneezing. In 1947 he was diagnosed, after radiological investigation, as a case of ankylosing spondylitis, and in 1953 he had radiotherapy to the spine. In February 1955 he developed pain and swelling of the left shoulder and right knee and these also were treated with radiotherapy. In August 1955 he had haematuria and this persisted for 3 months. Urological assessment by intravenous and retrograde pyelography and cystoscopy did not demonstrate any abnormality. Towards the end of October 1955 a guinea-pig was inoculated with material derived from a 24-hour specimen of urine. The patient was at that time in hospital in Australia, and was, at his own request, sent home to this country by sea. Just before his arrival in this country he developed a swelling ofthe right forearm. It was not at first obvious that this swelling was a haematoma and he received iiitramuscular injections of penicillin which resulted in further extensive bruising of the left thigh. In view of a probable haemostatic defect he was admitted for investigation.Physical exmuination. On physical examination, there was evidence of recent bruising of the right forearm and left thigh. The spine was rigid, and there was an effusion in the right knee joint. Radiological assessment revealed the changes of aiikylosiiig spondylitis with obliteration of the joint spaces between the articular facets in the lumbar and lower thoracic spine. There was extensive ligamentous ossification in relation to these joints and also on the vertebral bodies in the region of D.10-L.2. Both sacro-iliac joints were obliterated.Haeniatologicalzndings. The haemoglobin level was 7.3 g. per IOO inl. The films ofthe peripheral blood and of the sternal marrow did not reve...

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An Unusual Circulating Anticoagulant in Systemic Lupus Erythematosus

Cited by 28 publications

References 0 publications

Acquired Inhibitors in Nonhemophilic Patients

Acquired Inhibitors in Nonhemophilic Patients

Unusual Circulating Anticoagulant in a Patient with Systemic Lupus Erythematosus

An Atypical Circulating Thromboplastin Inhibitor

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