An Unusual Cause of Neutropenic Fever: Spontaneous Pantoea agglomerans Bacteremia in an Adult

Zaccone, V.; Lockwood, Mary Kae; Ticona, J Rojas; Jouharian, Pedram; Zamora, Michelle; Hampton, Christopher; Sidiqi, Baho; Kumar, Samir; McFarlane, Isabel M.

doi:10.12691/ajmcr-8-9-9

Cited by 4 publications

(3 citation statements)

References 16 publications

(17 reference statements)

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“…The lack of evidence for oral treatment of P. agglomerans bacteremia has often led to prolonged intravenous treatment [ 16 , 17 ]. Since the patient refused to complete the inpatient course of IV antibiotics, the pharmacy team researched possible oral options for the patient to continue after leaving the hospital [ 12 , 14 , 18 ]. Based on this research, the decision to initiate oral levofloxacin was made.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Pantoea agglomerans Bacteremia Using Oral Antibiotics

Penner

Romans

Tah

et al. 2022

Case Reports in Infectious Diseases

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A 30-year-old female with a medical history of gastrointestinal reflux and intravenous methamphetamine use was admitted to the hospital with complaints of fever and chills. Pantoae agglomerans was isolated in one out of two blood cultures. Although information was limited about the duration and efficacy of oral antibiotics to treat this type of infection, the patient recovered with oral antibiotic treatment following a short course of intravenous antibiotics.

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Section: Discussionmentioning

confidence: 99%

Successful Treatment of Pantoea agglomerans Bacteremia Using Oral Antibiotics

Penner

Romans

Tah

et al. 2022

Case Reports in Infectious Diseases

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“…(2020) indicated that Pantoea could induce fibrinonecrotic placentitis and abortions in mare. Zaccone et al. (2020) reported that Pantoea was closely related to bacteremia in humans.…”

Section: Discussionmentioning

confidence: 99%

Microbiome Analysis Reveals the Attenuation Effect of Lactobacillus From Yaks on Diarrhea via Modulation of Gut Microbiota

Dong

Liu

et al. 2021

Front. Cell. Infect. Microbiol.

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Domestic yaks (Bos grunniens) are indigenous to the Tibetan Plateau and display a high diarrhea rate due to poor habitat and husbandry conditions. Lactobacillus has been shown to exert beneficial effects as antimicrobial, growth promotion, and gut microbiota in humans and/or murine models, but the relevant data regarding Lactobacillus isolated from yaks was unavailable. Therefore, this study aimed to investigate the effects of Lactobacillus from yaks on the intestinal microbial community in a mouse model and determine whether Lactobacillus supplementation contributed in alleviating diarrhea by modulating gut microbiota. A total of 12 ileac samples from four groups were collected for 16S rRNA gene amplicon sequencing of V3-V4 region. Results revealed that although Lactobacillus supplementation did not change the diversity of gut microbiota in mice, the proportion of some intestinal microbiota significantly changed. Specifically, the proportion of Lactobacillus and Sphingomonas in the Lactobacillus treated-group (L-group) were increased as compared to control group (C-group), whereas Pantoea, Cutibacterium, Glutamicibacter, Turicibacter, Globicatella, Microbacterium, Facklamia, unidentified_Corynebacteriaceae, Brachybacterium, and Staphylococcus were significantly decreased in the L-group. In contrast, Escherichia coli (E. coli) infection significantly decreased the proportion of beneficial bacteria such as Globicatella, Acinetobacter, Aerococcus, and Comamonas, while loads of pathogenic bacteria significantly increased including Roseburia and Megasphaera. Interestingly, Lactobacillus administration could ameliorate the microbial community structure of E. coli-induced diarrheal mice by reducing the relative abundance of pathogenic bacteria such as Paenibacillus, Aerococcus, Comamonas, Acinetobacter, Corynebacterium, Facklamia, and Globicatella. Results in this study revealed that Lactobacillus supplementation not only improved the gut microbiota but also alleviated diarrhea in mice, which may be mediated by modulating the composition and function of gut microbiota. Moreover, this study is expected to provide a new theoretical basis for the establishment of a preventive and treatment system for diarrhea in yaks.

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“…P. agglomerrans infection in humans is typically mild and can manifest as localized or generalized infections. However, it has the potential to cause even life‐threatening complications such as sepsis, abscess, 17 infective endocarditis, pneumonia, 18 urinary tract infection, 18 septic arthritis, 19 neutropenic fever, 20 endophthalmites, 21 osteomyelitis, 22 and periostitis 5 . In hemodialysis patients, one study reported infective endocarditis of the mitral valve as a predominant complication associated with this infection 3 …”

Section: Introductionmentioning

confidence: 99%

Pantoea agglomerans: A rare infectious outbreak affecting maintenance hemodialysis patients in a tertiary care hospital

Hassan,

Saleem,

Haneef

et al. 2023

Seminars in Dialysis

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BackgroundPantoea agglomerans is an environmental pathogen known to cause infection in immunocompromised individuals, particularly after thorn injuries. However, previous data showed few cases of human disease caused by contaminated medical products such as parenteral nutrition, anesthetic agents, blood, and peritoneal dialysis solutions. Infection in hemodialysis patients is rare. In this study, we presented a detailed account of several hemodialysis patients infected with this contagious pathogen and compared them with noninfected dialysis patients.MethodsWe retrospectively reviewed the hospital records of 105 hemodialysis patients. Seventeen of 105 patients were diagnosed with P. agglomerans infection. We carefully analyzed their entire in‐hospital course.ResultsAmong infected patients, 52.9% were male with a median age of 49 (IQR: 32–66) years. Compared to the noninfected patients, age below 50 years, prior kidney transplantation, prior immunosuppression and antibiotics use, and dialysis via a tunneled vascular catheter were the significant epidemiological features. Despite negative microbiological investigations, we suspect the possible infectious spread via infected central venous catheter was the likely infectious source. Most importantly, all patients responded well to intravenous antibiotics. Only two patients required the removal of the tunneled catheter. Their mortality rate was 0%.ConclusionP. agglomerans infection, although considered rare, is becoming increasingly prevalent among dialysis patients. Its occurrence must be appraised as an infectious outbreak rather than mere contamination. Prompt treatment, source identification, and early implementation of preventive strategies should always be the goal to curtail this infection at an early stage.

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An Unusual Cause of Neutropenic Fever: Spontaneous Pantoea agglomerans Bacteremia in an Adult

Cited by 4 publications

References 16 publications

Successful Treatment of Pantoea agglomerans Bacteremia Using Oral Antibiotics

Successful Treatment of Pantoea agglomerans Bacteremia Using Oral Antibiotics

Microbiome Analysis Reveals the Attenuation Effect of Lactobacillus From Yaks on Diarrhea via Modulation of Gut Microbiota

Pantoea agglomerans: A rare infectious outbreak affecting maintenance hemodialysis patients in a tertiary care hospital

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