An Unusual Cause of Infective Endocarditis: Proteus mirabilis Bacteremia from an Infected Pressure Ulcer

Liu, Chun-Hao; Chang, Wei-Jung; Chin, Chuen

doi:10.1016/j.ijge.2014.09.003

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Finally, 16 met the present study's inclusion criteria. 8,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] The review process is graphically presented in Figure 1.…”

Section: Literature Searchmentioning

confidence: 99%

Infective endocarditis by Proteus species: a systematic review

Ιωάννου¹,

Vougiouklakis²

2020

Germs

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Proteus spp. are members of the Enterobacteriaceae family and are Gram-negative, rod-shaped bacteria known to mainly cause urinary tract infections (UTIs) in humans. However, even though scarce evidence exists suggesting their potential to cause infective endocarditis (IE), a study summarizing the existing evidence is lacking. The purpose of this study was to systemically review all published cases of IE by Proteus species in the literature. A systematic review of PubMed, Scopus and Cochrane Library (through 5 th May 2020) for studies providing epidemiological, clinical and microbiological data as well as data on treatment and outcomes of IE by Proteus species was performed. A total of 16 studies, containing data of 16 patients, were included. A prosthetic valve was present in 25%, while the most common causative pathogen was P. mirabilis. Aortic valve was the most common infected site in 33.3%, followed by mitral valve in 26.7%. Diagnosis was set with transesophageal echocardiography in 37.5%, and transthoracic echocardiography in 25%, while the diagnosis was set at autopsy in 25%. Fever and sepsis were present in 100% and 84.6%, respectively. Aminoglycosides and cephalosporins were the most common antimicrobials used for treatment. Clinical cure was noted in 62.5%, while overall mortality was 43.8%. This systematic review describes IE by Proteus species in detail and provides information on epidemiology, clinical presentation, treatment and outcomes.

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“…Finally, 16 met the present study's inclusion criteria. 8,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] The review process is graphically presented in Figure 1.…”

Section: Literature Searchmentioning

confidence: 99%

Infective endocarditis by Proteus species: a systematic review

Ιωάννου¹,

Vougiouklakis²

2020

Germs

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“…Only one other patient who we know of had P. mirabilis pneumonia simultaneously 8. One patient’s bacteremia and endocarditis stemmed from an infected pressure ulcer9 and four from urinary tract infections 7…”

Section: Discussionmentioning

confidence: 99%

Proteus mirabilisendocarditis

et al. 2019

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A 62-year-old man was admitted to the emergency department due to fever and acute heart failure. A transthoracic echocardiogram revealed severe aortic valve obstruction. He was an hepatic transplant recipient and was medicated with everolimus. He underwent mitral and aortic valve replacement with prosthetic valves 4 years ago. Due to his medical background, therapy and clinical presentation, empirical therapy for infective endocarditis was started. Transoesophageal echocardiogram showed severe aortic valve regurgitation but no other findings suggestive of endocarditis. Computed tomography (CT) revealed pulmonary infiltrates compatible with infection and no evidence of septic embolisation. Multiple sets of blood cultures were negative. Proteus mirabilis was isolated in bronchial lavage and antibiotic therapy was adjusted. The patient underwent aortic valve replacement, with no macroscopic findings suggestive of endocarditis. P. mirabilis was isolated in the surgically removed valve. Dual antibiotic therapy was successfully administered for 6 weeks.

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Endocarditis of Native Valve due to Proteus mirabilis: Case Report and Literature Review

Tiri

Priante²,

Mariottini

et al. 2021

SN Compr. Clin. Med.

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Endocarditis due to Proteus mirabilis is very uncommon and the optimal surgical and/or antibiotic treatment is not well defined. Guidelines from the AHA and ESC recommend prolonged courses of combined antibiotic therapy but information regarding the clinical presentation, the choice of treatment, the surgical management, and the duration of therapy can only be taken from clinical cases reported in literature. We describe a case of native valve endocarditis due to Proteus mirabilis, successfully treated with antibiotic therapy alone with a review of the relevant literature on this topic.

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An Unusual Cause of Infective Endocarditis: Proteus mirabilis Bacteremia from an Infected Pressure Ulcer

Cited by 3 publications

References 13 publications

Infective endocarditis by Proteus species: a systematic review

Infective endocarditis by Proteus species: a systematic review

Proteus mirabilisendocarditis

Endocarditis of Native Valve due to Proteus mirabilis: Case Report and Literature Review

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