An unusual cause of an ankle mass

Prinja, Aditya; Roberts, Catherine; Doherty, T.; Oddy, Michael

doi:10.1136/bcr-2014-204253

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Using a literature search, 20 evaluable cases of eumycetoma caused by Fusarium species were retrieved and included in our analysis from 1964 till 2016, (Table ), while three articles could not be acquired . Cases were reported from the following continents: Africa (n = 5; 25%), Asia (n = 4; 20%), North America (n = 3; 15%), South America (n = 4; 20%), and Europe (n = 2; 10%).…”

Section: Resultsmentioning

confidence: 99%

“…Using a literature search, 20 evaluable cases of eumycetoma caused by Fusarium species were retrieved and included in our analysis from 1964 till 2016, 15,[17][18][19][20][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] (Table 1), while three articles could not be acquired. 14,42,43 Cases were reported from the following continents:…”

Section: Types Of Articlesmentioning

confidence: 99%

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Fusarium species causing eumycetoma: Report of two cases and comprehensive review of the literature

Al‐Hatmi

Bonifáz

Tirado‐Sánchez

et al. 2016

Mycoses

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Recently, mycetoma was added to the World Health Organization's list of neglected tropical disease priorities. Fusarium as a genus has been reported to cause eumycetoma, but little is known about the species involved in this infection and their identification. In this study, molecular tools were applied to identify Fusarium agents from human eumycetoma cases. The partial translation elongation factor 1-alpha (TEF-1α) gene was used as diagnostic parameter. Two additional cases of eumycetoma, due to F. keratoplasticum and F. pseudensiforme, respectively, are presented. A systematic literature review was performed to assess general features, identification, treatment and outcome of eumycetoma infections due to Fusarium species. Of the 20 reviewed patients, the majority (75%) were male. Most agents belonged to the F. solani species complex, ie F. keratoplasticum, F. pseudensiforme, and an undescribed lineage of F. solani. In addition, F. thapsinum, a member of Fusarium fujikuroi species complex was encountered. The main antifungal drugs used were itraconazole, ketoconazole and amphotericin B, but cure rates were low (15%). Partial response or relapse was observed in some cases, and a case ended in amputation. Clinical management of eumycetoma due to Fusarium is complex and combination therapy might be required to increase cure rates.

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Section: Resultsmentioning

confidence: 99%

Section: Types Of Articlesmentioning

confidence: 99%

Fusarium species causing eumycetoma: Report of two cases and comprehensive review of the literature

Al‐Hatmi

Bonifáz

Tirado‐Sánchez

et al. 2016

Mycoses

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“…Due to extensive deep dermal invasion, the surgical procedure considered was debulking rather than eradication. 5 Further intraoperative deep tissue specimens were sent for microbiology and histopathology, with both again confirming primary diagnosis of Actinomyces spp. Sensitivity patterns from the culture of intraoperative tissue samples confirmed the isolated strain of Actinomyces sp was sensitive to penicillin.…”

Section: Treatmentmentioning

confidence: 99%

Chronic Madura foot: mycetoma and/orActinomycesspp or actinomycosis

Gannass

2018

BMJ Case Reports

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A 58-year-old agricultural worker from a remote Western province farming community in Saudi Arabia presented with a 2-year history of right plantar foot soft tissue mass. According to the patient, the swelling had gradually increased in size over a few years, but it was painless and thus had not restricted him from continuing to farm until the lesion started to affect mobility. An MRI, microbiology and histopathology reported a rare infectious agent—Actinomyces spp, otherwise referred to as Madura foot. Three-dimensional CT aided in a preoperative surgical plan which included mass excision/debulking for this challenging lesion. Full eradication was not possible, and the patient required prolonged anti-infective therapy (>6 months) along with close surveillance to map resolution of infective symptoms.

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An updated list of eumycetoma causative agents and their differences in grain formation and treatment response

van de Sande,

Fahal

2024

Clin Microbiol Rev

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SUMMARY In 2023, the World Health Organization designated eumycetoma causative agents as high-priority pathogens on its list of fungal priority pathogens. Despite this recognition, a comprehensive understanding of these causative agents is lacking, and potential variations in clinical manifestations or therapeutic responses remain unclear. In this review, 12,379 eumycetoma cases were reviewed. In total, 69 different fungal species were identified as causative agents. However, some were only identified once, and there was no supporting evidence that they were indeed present in the grain. Madurella mycetomatis was by far the most commonly reported fungal causative agent. In most studies, identification of the fungus at the species level was based on culture or histology, which was prone to misidentifications. The newly used molecular identification tools identified new causative agents. Clinically, no differences were reported in the appearance of the lesion, but variations in mycetoma grain formation and antifungal susceptibility were observed. Although attempts were made to explore the differences in clinical outcomes based on antifungal susceptibility, the lack of large clinical trials and the inclusion of surgery as standard treatment posed challenges in drawing definitive conclusions. Limited case series suggested that eumycetoma cases caused by Fusarium species were less responsive to treatment than those caused by Madurella mycetomatis . However, further research is imperative for a comprehensive understanding.

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An unusual cause of an ankle mass

Cited by 4 publications

References 16 publications

Fusarium species causing eumycetoma: Report of two cases and comprehensive review of the literature

Fusarium species causing eumycetoma: Report of two cases and comprehensive review of the literature

Chronic Madura foot: mycetoma and/orActinomycesspp or actinomycosis

An updated list of eumycetoma causative agents and their differences in grain formation and treatment response

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