An Unusual Case of Sinus Arrest

Kirkwood, Ian; Duckworth, R. A.

doi:10.1093/bja/55.12.1273

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Misuse Of Drugs1

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1987

1993

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Cited by 23 publications

(1 citation statement)

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“…Several drugs used in anaesthesia have a tendency to cause bradycardia, including suxamethonium, fentanyl and halothane. Recent reports have linked the use of vecuronium to the development of bradyarrhythmias and even asystole (Kirkwood and Duckworth, 1983;Milligan and Beers, 1985;Clayton, 1986;Pollock, 1986). This is most likely to occur in patients already at risk of bradycardia or during parasympathetic stimulation by peritoneal stretching.…”

Section: Misuse Of Drugsmentioning

confidence: 99%

Anaesthetic Contribution to Maternal Mortality

Morgan

1987

British Journal of Anaesthesia

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Section: Misuse Of Drugsmentioning

confidence: 99%

Anaesthetic Contribution to Maternal Mortality

Morgan

1987

British Journal of Anaesthesia

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Inhibition by vecuronium of carbachol-induced influx of22Na2+,45Ca2+ and secretion of catecholamines in cultured bovine adrenal medullary cells

Wada

Arita

Takara

et al. 1989

Naunyn-Schmiedeberg's Arch. Pharmacol.

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In cultured bovine adrenal medullary cells, vecuronium, pancuronium and D-tubocurarine reduced carbachol-induced 45Ca2+ influx and catecholamine secretion by inhibiting 22Na+ influx via nicotinic receptor-ion channel complex with IC50 values of 0.43, 7.6 and 3.9 mumol/l, respectively. IC50 values of pancuronium and D-tubocurarine observed in adrenal medulla were one order of magnitude higher than the plasma concentrations of these muscle relaxants reported to produce 50% neuromuscular blockade, while IC50 of vecuronium was quite close between adrenal medulla and skeletal muscle.

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