Gastrointestinal lipomas are benign, slow-growing tumors that are typically diagnosed incidentally during endoscopy [1, 2]. They are more commonly located in the right colon; rectal involvement is uncommon [2-5]. Lipomas are characteristically asymptomatic but depending on their location and size [1], they can cause symptoms such as bleeding, obstruction, intussusception or prolapse [1, 2, 4]. Only three cases of rectal lipomas presenting with prolapse have been reported in the literature, and they are usually treated surgically. We present the case of a 65-year-old woman who was referred to the Gastroenterology Department because of symptomatic intermittent rectal prolapse. The patient reported the need to manually reinsert the prolapse. Colonoscopy revealed a large subepithelial lesion in the distal rectum, adjacent to the upper margin of the anal canal (▶ Fig. 1). Axial contrast-enhanced pelvic computed tomography scan suggested a lipomatous lesion in the rectum. An echoendoscopy, using a dedicated anal probe (7.5 MHz), revealed a well-demarcated, hyperechogenic, homogeneous lesion in the submucosa (▶ Fig. 2), suggesting a lipoma [5]. The patient was proposed for endoscopic resection. ▶ Fig. 3 Endoscopic submucosal dissection (ESD) of the lipoma. a Endoscopic view of the lipoma. b Ligation of the vascular pedicle with a hemostatic clip; forward traction using forceps. c Endoscopic view of the lesion and the mucosal defect after ESD.