An unusual case of (pseudo)hypertriglyceridaemia

Abstract

A high concentration of glycerol in plasma is an interfering factor in the determination of triglycerides, giving rise to (pseudo)hypertriglyceridaemia. Hyperglycerolaemia may be due to the presence of exogenous glycerol or due to endogenous glycerol accumulation. In the present case report, a 57-year-old male patient with end-stage renal disease presented with a pseudohypertriglyceridaemia based on a pronounced hyperglycerolaemia. The hyperglycerolaemia was due to chronic intake of glycerol-containing alcoholic beverages in combination with a reduced glycerol clearance and glycerol kinase activity. In conclusion, an unexplained hypertriglyceridaemia in patients with an impaired renal function should raise the suspicion of hyperglycerolaemia.

The effects of long-term moderate exercise and Western-type diet on oxidative/nitrosative stress, serum lipids and cytokines in female Sprague Dawley rats

“…It should also be mentioned that our method for the measurement of TG does not distinguish between TG and free glycerol. However, the blood concentration of free glycerol is < 1 mg/dL, which accounts for approximately 10 mg/dl of triglycerides [ 55 ]. Considering that in the SD rats used in this study TG concentrations ranged between 100 and 400 mg/dl, the unintentional detection of free glycerol does not represent a relevant confounder of our results.…”

Bittersweet: relevant amounts of the common sweet food additive, glycerol, accelerate the growth of PC3 human prostate cancer xenografts

“…Probably the best illustration of how the dose in our study compares to one potential dietary source is the documentation that Duvel beer contains 227 mg/dL glycerol (white wine can contain 469 mg/dL) [11]. Assuming consumption of 500 mL of beer during a 1-h period, this would amount to a dose of 15.1 mg/kg bw/h in a 75 kg male.…”

Glycerol kinase deficiency in adults: Description of 4 novel cases, systematic review and development of a clinical diagnostic score

“…In addition to GKD, there are other rare diseases that combined could explained the falsely elevated TG levels. For example, a severe renal and hepatic disease combined with a high consumption of white wine or beer, drinks especially rich in glycerol, would produce a high consume of glycerol that would not be removed from the blood due to kidney failure [33].…”