An unusual case of neonatal langerhans cell histiocytosis presenting with diffuse hemorrhagic nodules and a cutaneous abdominal mass

Wong, Lai‐San

doi:10.4103/0019-5154.160545

Cited by 2 publications

(2 citation statements)

References 5 publications

(7 reference statements)

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“…Combining with the result of the bone lesions biopsy, the patient's previous multiple serosal cavities effusion uids could also be suspected as a clinical manifestation of LCH involvement of serosa. Lai-San Wong [12] reported a case of neonatal LCH with diffuse hemorrhagic nodules and a huge mass of in right abdominal skin, with elevated lactate dehydrogenase (LDH), which had never been published in LCH before. Ricardo Mejia, et al [13]reported a patient with endocrine problems due to a suprasellar mass.…”

Section: Discussionmentioning

confidence: 99%

Langerhans Cell Histiocytosis: A Complicated Case Report and Literature Review

Zhong

Shen

Ding

et al. 2022

Preprint

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Background: Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology, characterized by monoclonal proliferation and organ infiltration of Langerhans cells. The clinical manifestations are various, and may involve single or multiple organs. A case of LCH is introduced and the diagnosis and treatment are discussed. Case presentation: A 23-year-old woman presented with a huge mass in the left lower abdomen. Computed tomography (CT) of the lung revealed multiple diffuse nodules of different sizes in the right lung. The left thorax was collapsed, the left pleura was thickened and adhered, and a small, encapsulated effusion was observed in the thoracic cavity. Enhanced CT of the whole abdomen showed a huge cystic low-density focus on the left lower abdomen, multiple nodules in the spleen, and multiple osteolytic bone destruction in the spine, thorax, and pelvis. The possibility of LCH was considered based on the presence of diffuse reticulum nodules in the lungs observed in CT imaging. The patient was performed ultrasound-guided abdominal puncture, drainage, and chemotherapy with "vinorelbine and cisplatin". Follow-up is ongoing. Conclusion: LCH involving the serosal membrane is rare. The final diagnosis requires histopathological examination of the involved tissue. But in most cases, it’s enough to diagnose through the typical imaging changes in the lung, as observed by high-resolution computed tomography (HRCT), combined with certain clinical observations. Currently, there are no clearly established treatment guidelines for LCH. At present, systemic chemotherapy is the main treatment method that has been shown to improve patient’s prognosis.

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Section: Discussionmentioning

confidence: 99%

Langerhans Cell Histiocytosis: A Complicated Case Report and Literature Review

Zhong

Shen

Ding

et al. 2022

Preprint

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show abstract

“…[ 1 ] The clinical stratification according to the extent of LCH is a very important factor in treatment. [ 3 14 ]…”

Section: Discussionmentioning

confidence: 99%

Langerhans Cell Histiocytosis: A Case Report with Unusual Cutaneous Manifestation

et al. 2018

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Langerhans cell histiocytosis (LCH) is characterized by idiopathic monoclonal infiltration of Langerhans cells in different organs such as the skeleton, skin, pituitary gland, liver, spleen, lungs, and the hematopoietic system. Skin lesions are common in LCH and affect about 40% of cases. It is reported that skin lesions are usually the first manifestation of LCH in 80% of patients. Usually, cutaneous presentations of LCH in adults are generalized or seborrhea-like lesions and it is often the first manifestation of disease. Here, we describe a 45-year old female who was known case of hypothyroidism, systemic lupus erythematosus, and diabetes insipidus. In our patient, cutaneous involvement was unusual. It was single and presented in unusual site (ankle) and before developing such lesion, she had diabetes insipidus for several years due to the involvement of pituitary gland.

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An unusual case of neonatal langerhans cell histiocytosis presenting with diffuse hemorrhagic nodules and a cutaneous abdominal mass

Cited by 2 publications

References 5 publications

Langerhans Cell Histiocytosis: A Complicated Case Report and Literature Review

Langerhans Cell Histiocytosis: A Complicated Case Report and Literature Review

Langerhans Cell Histiocytosis: A Case Report with Unusual Cutaneous Manifestation

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