An unusual case of invasive lobular carcinoma with abundant extracellular mucin

Hort, Amy; O’Toole, Sandra A.; Yunaev, Michael

doi:10.1016/j.pathol.2021.04.006

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Previously, mucin in ILC had exclusively been described in the intracellular compartment and extracellular localisation was recognised as a sign of ductal differentiation 54,55 . To date, 39 cases of ILCEM have been reported in the literature 53,56–67 . These tumours were more frequently diagnosed in post‐menopausal women (median age = 62 years; range = 31–87), primarily presenting with palpable masses.…”

Section: Invasive Lobular Carcinomas With Extracellular Mucinmentioning

confidence: 99%

“…54,55 To date, 39 cases of ILCEM have been reported in the literature. 53,[56][57][58][59][60][61][62][63][64][65][66][67] These tumours were more frequently diagnosed in post-menopausal women (median age = 62 years; range = 31-87), primarily presenting with palpable masses. Multifocality was not uncommon, and most of the tumours (69%) were ≥ 2 cm (range = 0.7-10 cm).…”

Section: Invasive Lobular Carcinomas With Extracellular Mucinmentioning

confidence: 99%

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Update on lobular lesions of the breast

Kuba

2022

Histopathology

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The current histological classification of in‐situ and invasive lobular carcinomas (ILCs) includes different morphological variants, some of which have been recently described. In this review, we will focus upon: (i) the diagnostic criteria of non‐invasive lobular neoplasia and treatment implications across different countries; (ii) utility and limitations of immunohistochemistry; (iii) recently described variants of ILC; and (iv) the significance of lobular differentiation in invasive carcinoma for clinical management.

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Section: Invasive Lobular Carcinomas With Extracellular Mucinmentioning

confidence: 99%

Section: Invasive Lobular Carcinomas With Extracellular Mucinmentioning

confidence: 99%

Update on lobular lesions of the breast

Kuba

2022

Histopathology

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“…ILC with extracellular mucin production was first described by Rosa et al in 2009 [ 20 ]. A review of the relevant literature has yielded 12 papers describing 39 cases in toto [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. In some cases, important clinicopathological data, such as tumor size, lymph node, hormone receptor, Her−2 status, therapy, and follow-up information, are not mentioned.…”

Section: Invasive Lobular Carcinoma With Extracellular Mucin Productionmentioning

confidence: 99%

Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

et al. 2022

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Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and β-catenin staining) features. Moreover, ILC displays a poor response to neoadjuvant therapy, a different metastatic pattern compared to invasive breast carcinoma of no special type, as well as unique molecular characteristics. In addition to the classic variant of invasive lobular carcinoma, several other well-recognized variants exist, including classic, alveolar, tubulolobular, solid, pleomorphic, signet-ring, and mixed. Furthermore, three novel variants of invasive lobular carcinoma, i.e., with extracellular mucin production, papillary features, and tubular elements, have been described during the last decade. We herewith focus on the unique morphological and immunohistochemical characteristics of these novel varieties of invasive lobular carcinoma, as well as differential diagnostic considerations and potential diagnostic pitfalls, especially when dealing with biopsy specimens.

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An unusual case of invasive lobular carcinoma with abundant extracellular mucin

Cited by 2 publications

References 6 publications

Update on lobular lesions of the breast

Update on lobular lesions of the breast

Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls

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