An unusual case of IgA-dominant postinfectious glomerulonephritis: a case report and review of the literature

Abstract

We report a case of IgA-dominant postinfectious glomerulonephritis in a 49-yearold man presenting with acute kidney injury, nephrotic range proteinuria and hematuria. He suffered from ischemic heart disease, cardiac insufficiency, mitral regurgitation, tricuspid insufficiency, septal aneurysm and hypertension. Renal biopsy revealed segmental and focal endocapillary and mesangial hypercellularity, and thickening of the glomerular capillary wall. Immunofluorescence showed co-dominant strong coarse granular immunostaining of IgA, IgG and C3 mainly along the glomerular capillary wall. On electron microscopy some large subepithelial hump-shaped deposits were present. In summary, this case demonstrates the presence of a broad spectrum of glomerular histological findings in postinfectious glomerulonephritis.

Clinicopathologic Features of Infection-Related Glomerulonephritis with IgA Deposits: a French Nationwide Study

“…Nevertheless, the association between diabetes and IRGN-IgA is inconstant, reported in 8 to 55 % of patients in previous studies and in 44 % of patients in our study. 10,12,[16][17][18][22][23][24] As seen since the first report, Staphylococcus represents the most frequent germ (78% in our study, 60 to 100% in other studies). 10,12,17,18,24 A higher frequency of MRSA was observed in Asian and American studies (50 to 60%) compared to our cohort (15%).…”

Clinicopathologic features of infection-related glomerulonephritis with IgA deposits: a French Nationwide study

“…The initial description by Nasr et al reported diabetic nephropathy in all biopsies. Nevertheless, the association between diabetes and IRGN-IgA is inconstant, reported in 8 to 55% of patients in previous studies and in 44% of patients in our study [10,12,[16][17][18][22][23][24]. As seen since the first report, Staphylococcus represents the most frequent germ (78% in our study, 60 to 100% in other studies) [10,12,17,18,24].…”

Cancer-associated glomerulopathy; an updated review on current knowledge

“…Cancer-related glomerulopathy can be differentiated from idiopathic glomerulopathy by considering several factors. For example, CAG is more common in older adults, while idiopathic glomerulopathy can occur at any age (3,5,20). Moreover, the presence of an underlying malignancy is a risk factor for developing CAG.…”

“…The most common glomerular lesions that are caused by cancers is paraneoplastic glomerulopathy (4). Membranous nephropathy is the most common glomerular pathology associated with solid tumors (5). Various solid tumors, comprising lung cancers or renal cell carcinomas have been connected with vasculitis or rapidly progressive glomerulonephritis (3)(4)(5)(6)(7)(8).…”

“…Membranous nephropathy is the most common glomerular pathology associated with solid tumors (5). Various solid tumors, comprising lung cancers or renal cell carcinomas have been connected with vasculitis or rapidly progressive glomerulonephritis (3)(4)(5)(6)(7)(8). This review paper provides an overview of the current understanding of CAG, including its pathogenesis, clinical presentation, diagnostic criteria, and management strategies.…”