An unusual case of gastric lymphoma presenting as linitus plastica

Intraoral Cellular Schwannoma Involving Maxillary Gingiva: A Rare Case Report

“…In the present case, p53 immunohistochemical staining was performed to rule out malignancy. On immunohistochemistry, CS are known to be positive for S100 which reflects the neural nature of the lesion [ 7 , 9 ], as was performed in the present case that yielded positive results. Ki-67 labeling indices ≥20% is indicative of malignant peripheral nerve sheath tumor with 87% sensitivity and 96% specificity which was not observed in the present case.…”

“…Schwannoma, also known as neurilemmoma, is an uncommon, slow growing, solitary, benign nerve sheath tumor that originates from peripheral, cranial or autonomic nerves containing schwann cells [ 9 ] Histologically, there are seven variants of schwannoma described in the literature which includes classical (Verocay), plexiform, cellular, cranial nerve, melanotic, degenerated (ancient), and granular cell schwannoma [ 2 , 10 ] Verocay, in 1910 was the first to describe schwannoma microscopically and called it “Neurinoma,” while Arthur Stout, in 1935, coined the term neurilemmoma [ 7 , 10 ]. Between 25%–45% of schwannomas are located in the head and neck region, with the eighth cranial nerve being most commonly affected.…”

“…Between 25%–45% of schwannomas are located in the head and neck region, with the eighth cranial nerve being most commonly affected. Only 1% of the schwannoms are known to occur intraorally, with tongue being the commonest site [ 7 , 9 ]. To the best of our knowledge, so far only four cases of intraoral cellular schwannoma have been reported in literature.…”

“…Schwannoma can occur either in an encapsulated form, which is more common or in a pedunculated form, where it resembles a fibroma. Clinically, it often presents as a painless slow growing, solitary, exophytic, non-indurated, well circumscribed lesion, with a smooth surface [ 9 ]. The very first case in intraoral CS reported in 1996 was an incidental finding [ 5 ].…”

“…Depending upon the clinical presentation of the lesion, various differential diagnoses are considered including fibroma, granular cell tumor, pyogenic granuloma, giant cell lesion, fibrous hyperplasia, traumatic fibroma, mucocele, minor salivary gland tumors, and rarely, malignant tumors, such as squamous cell carcinoma and sarcomas [ 2 , 9 ]. Radiographically, schwannomas of jaw appears as well-demarcated, unilocular radiolucencies within a thin sclerotic border.…”