An unusual case of eyelid metastasis from a rectal primary

Abstract

A 26-year-old, human immunodeficiency virus. (HIV).negative male, a diagnosed case of locally advanced adenocarcinoma rectum underwent diversion colostomy and received preoperative radiotherapy with three-dimensional conformal radiotherapy. (3DCRT) to a dose of 25 Gy/5 Fx/8. days to 95% planning target volume. (PTV) with 3-field technique. (right and left lateral and posterior) by 6 and 15 MV photons. Postradiotherapy contrast-enhanced computed tomography. (CECT) chest and abdomen showed progressive disease. He was reviewed by oncosurgeon and considered inoperable. He presented with a swelling over upper eyelid, which on biopsy was proven as metastatic adenocarcinoma. He received three cycles of weekly chemotherapy and was planned for excision and reconstruction of eyelid. He finally succumbed due to small bowel obstruction, acute renal failure, and septicemia after an overall duration of survival of seven months. Eyelid metastases occur in less than one percent of malignant eye lesions in adults. To the best of our knowledge, this is the first case reported with a primary in rectum.

Breast metastasis of signet ring cell carcinoma from the colon: a case report

“…In general, there is a lack of experience in treatment of patients with rare-site metastasis. Goel and his colleagues reported an unusual case of locally advanced rectal cancer metastasizes to eyelid, which received preoperative radiotherapy and diversion colostomy for primary tumor [ 22 ]. When eyelid metastasis occurred, the patient treated with three cycles of weekly chemotherapy and was planned for excision and reconstruction of eyelid [ 22 ].…”

“…Goel and his colleagues reported an unusual case of locally advanced rectal cancer metastasizes to eyelid, which received preoperative radiotherapy and diversion colostomy for primary tumor [ 22 ]. When eyelid metastasis occurred, the patient treated with three cycles of weekly chemotherapy and was planned for excision and reconstruction of eyelid [ 22 ]. Unfortunately, the patient eventually died of small bowel obstruction, acute renal failure, and septicemia with an overall duration of survival of 7 months [ 22 ].…”

“…When eyelid metastasis occurred, the patient treated with three cycles of weekly chemotherapy and was planned for excision and reconstruction of eyelid [ 22 ]. Unfortunately, the patient eventually died of small bowel obstruction, acute renal failure, and septicemia with an overall duration of survival of 7 months [ 22 ]. For now, a majority of the patients with breast metastasis form colon received standard treatment as their primary tumor [ 23 ].…”

Periocular dermatoses

“…Up to 50% of cases are breast cancer-derived but also from cancer of the stomach, esophagus, lungs, and other organs. In 8% to 11% of cases, the primary cancer is from unknown origin ( Goel et al, 2015 ). Orbit metastases are infrequent also but must always be considered as a differential diagnosis in any patient with cancer with visual alterations ( Tabai et al, 2016 ).…”