An unusual case of diffuse large B‐cell lymphoma complicating a Crohn's disease

Mériam, Sabbah; Farhat, Fatma Ben; Bellil, N; Khanchel, Fatma; Ouakaa, A; Gargouri, Dalila

doi:10.1002/ccr3.3364

Cited by 4 publications

(8 citation statements)

References 11 publications

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“…Diffuse large B-cell lymphoma is a dreaded complication of inflammatory bowel diseases (IBD). Knowledge about lymphoma in patients with IBD is limited to epidemiological data and the description of risk factors [ 131 ]. However, clinicians should bear in mind that Crohn’s disease may be complicated by neoplasia such as adenocarcinomas or lymphomas, especially if the disease duration is long and the patient is under immunosuppressive therapy [ 132 ].…”

Section: Causes Of Nutrient Malabsorptionmentioning

confidence: 99%

Small and Large Intestine (I): Malabsorption of Nutrients

2021

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Numerous disorders can alter the physiological mechanisms that guarantee proper digestion and absorption of nutrients (macro- and micronutrients), leading to a wide variety of symptoms and nutritional consequences. Malabsorption can be caused by many diseases of the small intestine, as well as by diseases of the pancreas, liver, biliary tract, and stomach. This article provides an overview of pathophysiologic mechanisms that lead to symptoms or complications of maldigestion (defined as the defective intraluminal hydrolysis of nutrients) or malabsorption (defined as defective mucosal absorption), as well as its clinical consequences, including both gastrointestinal symptoms and extraintestinal manifestations and/or laboratory abnormalities. The normal uptake of nutrients, vitamins, and minerals by the gastrointestinal tract (GI) requires several steps, each of which can be compromised in disease. This article will first describe the mechanisms that lead to poor assimilation of nutrients, and secondly discuss the symptoms and nutritional consequences of each specific disorder. The clinician must be aware that many malabsorptive disorders are manifested by subtle disorders, even without gastrointestinal symptoms (for example, anemia, osteoporosis, or infertility in celiac disease), so the index of suspicion must be high to recognize the underlying diseases in time.

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Section: Causes Of Nutrient Malabsorptionmentioning

confidence: 99%

Small and Large Intestine (I): Malabsorption of Nutrients

2021

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“…DLBCL represents a fast-growing B-cell lymphoma, histologically identified by the widespread growth of large cancerous B lymphoid cells whose nucleus size matches or surpasses the nuclei of typical histiocytes [ 8 ]. In cases of CD, there is a potential for complications such as malignant adenocarcinoma or lymphoma, which can lead to small bowel perforation [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Malignant lymphoma of the gastrointestinal tract is a rare condition; in most cases, it takes place within the stomach and can affect the colon or small intestine [ 1 ]. About 70% of Crohn's disease (CD) patients will need surgery to help ease their symptoms, even with advanced medical treatments [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…About 70% of Crohn's disease (CD) patients will need surgery to help ease their symptoms, even with advanced medical treatments [ 2 ]. Patients with inflammatory bowel disease (IBD), especially those undergoing immunosuppressive therapy, have shown a higher occurrence of non-Hodgkin's lymphoma [ 1 ]. Perforations in the jejunum and ileum may develop simultaneously, or they may develop frequently as separate perforations throughout the long-term clinical course of CD [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…In cases of CD, complications can arise in the form of malignant adenocarcinoma or lymphoma, which can manifest as small bowel perforation [ 5 ]. Also, the reason behind the observed connection between CD and lymphoma remains unclear [ 1 ]. Herein, we present a 47-year-old woman with a history of CD who presented with acute abdominal pain.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Perforated small bowel lymphoma: a rare presentation of Crohn’s disease

Herbawi,

Hroub,

Salloum

et al. 2024

Journal of Surgical Case Reports

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Adenocarcinoma and lymphoma, potential complications of Crohn's disease (CD), may result in small intestinal perforations, particularly in those on immunosuppressive therapy. The ileum is typically the site of small intestinal perforations in CD, and the link between CD and lymphoma remains uncertain. This case report explores a long-term CD patient on immunosuppressive therapy who presented with acute abdominal pain. Imaging revealed signs of intestinal perforation, successfully managed with surgery. The final pathology report confirms the diagnosis of diffuse large B-cell lymphoma. This report sheds light on the complicated nature of gastrointestinal lymphoma in CD patients.

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The Complex Relationship between Mechanisms Underlying Inflammatory Bowel Disease, Its Treatment, and the Risk of Lymphomas: A Comprehensive Review

Stasik,

Filip

2024

IJMS

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Patients with inflammatory bowel disease may be at higher risk of developing lymphomas and other cancers of the gastrointestinal tract. In addition, there may be a link between the use of thiopurines or anti-tumor necrosis factor drugs (anti-TNF) and these pathologies. The treatment of patients with Crohn’s disease who have previously been diagnosed with lymphoma is a challenge for gastroenterologists. In this report, we examine important clinical issues related to the treatment of patients with inflammatory bowel disease with active lymphoma, as well as of patients with hematological cancer history. In this discussion, we take into account most of the available treatments for inflammatory bowel disease, as well as the impact of chronic inflammation and viral infections. In addition, we try to find common ground for the development of lymphoproliferative disorders and autoimmune diseases. Patients with inflammatory bowel disease may be at higher risk of developing lymphomas and other cancers of the gastrointestinal tract. Chronic inflammatory processes and viral infections play an important role in carcinogenesis. In addition, there may be a link between the use of thiopurines or anti-TNF drugs and these pathologies. A significant risk of the development of lymphoma in people undergoing each therapy should be considered, and it should be estimated how much greater this risk will be in patients with a history of lymphoproliferative disorders. The following review is an attempt to answer which therapy would be the most appropriate for patients with Crohn’s disease and a history of lymphoma treatment. A lack of clear guidelines creates great challenges for doctors.

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An unusual case of diffuse large B‐cell lymphoma complicating a Crohn's disease

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 11 publications

Small and Large Intestine (I): Malabsorption of Nutrients

Small and Large Intestine (I): Malabsorption of Nutrients

Perforated small bowel lymphoma: a rare presentation of Crohn’s disease

The Complex Relationship between Mechanisms Underlying Inflammatory Bowel Disease, Its Treatment, and the Risk of Lymphomas: A Comprehensive Review

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