An unusual case of cutaneous hyaline‐vascular castleman’s disease with multicentric involvement and systemic symptoms

Cárdenas, Vanessa; Vitiello, Magalys; Miteva, Mariya; Amano, Masahiro; Romanelli, Paolo; Kerdel, Francisco A.

doi:10.1111/j.1365-4632.2009.04442.x

Cited by 5 publications

(2 citation statements)

References 11 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD diagnoses lack characteristic cutaneous findings, and there are few reports describing extranodal CD with cutaneous involvement. 4,18,19 Despite the rarity of this disease, we found several cases that enabled a comprehensive review of this disorder.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Manifestations of Castleman Disease: Histopathological Characteristics and Review of Literature

Zapata-Salazar¹,

Gómez‐Flores²,

Ocampo‐Candiani³

et al. 2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Castleman disease (CD) is a poorly understood lymphoproliferative disorder characterized by enlarged lymph nodes. The spectrum of differential diagnoses is wide, and it is hard to differentiate from other diseases. Cutaneous involvement of CD is rare, and studies that describe cutaneous dermatopathology of CD are scarce. The aim of this study was to collect case reports of CD with cutaneous manifestations and identify potential relevant histopathological features. We found that cases of CD with cutaneous manifestations often exhibited dermal lymphoid follicles with follicle center infiltration of lymphocytes and plasma cells. These dermal follicles also had regressive or atrophic germinal centers and were penetrated by hyalinized vessels. Patients with CD also consistently exhibited perivascular and deep dermal inflammatory infiltrate, primarily composed of lymphocytes and plasma cells. We intend to raise awareness of this rare entity and provide more histopathological information regarding its dermatological manifestations.

show abstract

Section: Discussionmentioning

confidence: 99%

Cutaneous Manifestations of Castleman Disease: Histopathological Characteristics and Review of Literature

Zapata-Salazar¹,

Gómez‐Flores²,

Ocampo‐Candiani³

et al. 2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…It is almost always associated with the plasma cell type of IMCD [12][13][14][15][16][17]. Rarely, patients with the hyalinevascular type of cutaneous multicentric Castleman disease have been reported [18].…”

Section: Discussionmentioning

confidence: 99%

Afebrile Pneumonia in a Patient With Multicentric Castleman Disease on Siltuximab: Infection Without Fever on Anti-Interleukin-6 Therapy

Cohen¹,

Nikanjam

Kato

et al. 2020

Cureus

View full text Add to dashboard Cite

Castleman disease is a lymphoproliferative disorder characterized by atypical lymph node hyperplasia and systemic symptoms; it can also affect the skin and blood counts. The condition is categorized by the extent of involvement (unicentric or multicentric) and the observed lymph node pathology (hyaline-vascular, plasma cell or mixed cellularity). Pathogenesis also has a role in the classification and treatment of multicentric Castleman disease; this variant can either be related to the presence of human herpesvirus-8 (HHV-8) infection or associated with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal proteins and skin changes) syndrome, or idiopathic. The principal cytokine responsible for causing idiopathic multicentric Castleman disease (IMCD) is interleukin-6 (IL-6). Therefore, treatment with agents that bind to IL-6 (such as siltuximab) or block the IL-6 receptor (such as tocilizumab) has been used. We report a woman with IMCD who was successfully being treated with siltuximab; her cutaneous manifestations and systemic disease (lung and lymph nodes) improved within three months. However, nine months after starting siltuximab, she developed a worsening cough and new infiltrates in the right lung on positron emission tomography/computed tomography (PET/CT) scan; there were no other constitutional symptoms such as fever, night sweats or fatigue. Differential diagnosis included Castleman disease recurrence, lung neoplasm and infection. Her pulmonary symptoms and infiltrates on scan resolved after treatment with systemic levofloxacin, indicating that she had an antibiotic-sensitive afebrile pneumonia. We postulate that her siltuximab therapy blocked the IL-6-associated fever and constitutional symptoms that normally are a hallmark of pneumonia. Therefore, patients who are receiving medications such as siltuximab and tocilizumab that block the IL-6 pathway and impair the acute phase inflammatory response may fail to manifest constitutional symptoms such as fever when infected.

show abstract

Marginal Zone Lymphoma and Other Related Post Germinal Center B Cell Lymphoproliferative Disorders of The Skin

2016

The Cutaneous Lymphoid Proliferations

View full text Add to dashboard Cite

An unusual case of cutaneous hyaline‐vascular castleman’s disease with multicentric involvement and systemic symptoms

Cited by 5 publications

References 11 publications

Cutaneous Manifestations of Castleman Disease: Histopathological Characteristics and Review of Literature

Cutaneous Manifestations of Castleman Disease: Histopathological Characteristics and Review of Literature

Afebrile Pneumonia in a Patient With Multicentric Castleman Disease on Siltuximab: Infection Without Fever on Anti-Interleukin-6 Therapy

Marginal Zone Lymphoma and Other Related Post Germinal Center B Cell Lymphoproliferative Disorders of The Skin

Contact Info

Product

Resources

About