Abstract:Ocular complications from topical cocaine abuse are rare. Impaired color vision, as in our patient, has been reported in cocaine-withdrawn patients. To our knowledge, this is the first described case of a bilateral and symmetric maculopathy associated with long-term intranasal cocaine use. To avoid a delay of treatment, ophthalmologists should be aware that a maculopathy with small defects in color vision may be related to adulterants added to cocaine when it is used intranasally.
“…[26] A class of designer drugs, the alkyl nitrites, including isopropyl nitrite and isobutyl nitrite, has been implicated in “poppers maculopathy.”[27,28,29] The offending agent is inhaled. Symptoms include decreased central visual acuity, central scotoma, phosphenes, and metamorphopsia.…”
Purpose of review
To review commonly encountered adverse ocular effects of illicit drug use.
Recent findings
Drug and alcohol abuse can produce a variety of ocular and neuro-ophthalmic side effects. Novel, so-called “designer,” drugs of abuse can lead to unusual ocular disorders. Legal substances, when used in manners for which they have not been prescribed, can also have devastating ophthalmic consequences.
Summary
In this review we will systematically evaluate each part of the visual pathways and discuss how individual drugs may affect them.
“…[26] A class of designer drugs, the alkyl nitrites, including isopropyl nitrite and isobutyl nitrite, has been implicated in “poppers maculopathy.”[27,28,29] The offending agent is inhaled. Symptoms include decreased central visual acuity, central scotoma, phosphenes, and metamorphopsia.…”
Purpose of review
To review commonly encountered adverse ocular effects of illicit drug use.
Recent findings
Drug and alcohol abuse can produce a variety of ocular and neuro-ophthalmic side effects. Novel, so-called “designer,” drugs of abuse can lead to unusual ocular disorders. Legal substances, when used in manners for which they have not been prescribed, can also have devastating ophthalmic consequences.
Summary
In this review we will systematically evaluate each part of the visual pathways and discuss how individual drugs may affect them.
“…81,143 For example, heroin is sometimes known to be cut with quinine, 82 cocaine has been reported to be cut with sodium bicarbonate, sugar, local anaesthetics, amphetamines, caffeine, or heroin. 66 Fourth, many news drugs are not detected by the regular screenings, which may lead to underreporting of drug-related ocular effects. 170 Lastly, the review of the evidence in this scoping review was mainly conducted by only one of the authors (VP), with partial validation by the other (BT).…”
Section: Discussionmentioning
confidence: 99%
“…Cocaine is commonly reported to induce blue-yellow colour vision impairments. [64][65][66][67] Studies using OCT have commonly reported the thinning of superior, inferior and nasal retinal nerve fibre layers, 68 or a thinning of the superior retinal nerve fibre layer, which may mimic glaucoma. 69 Other occasional reports include a case of vascular headache secondary to consumption of cocaine that led to blurry vision, a case of transient monocular blindness following intranasal consumption and a case of chorioretinal ischaemia associated with a profound loss of vision.…”
Illicit drugs and substances of abuse are increasingly used by adults and teenagers, with novel substances constantly becoming available. Many substances can cause ocular effects or visually threatening conditions. Current literature informing eye-care practitioners on these effects is scant. The present scoping review reports the ocular effects of most commonly used drugs and substances of abuse in the teenage and adult populations of North America. Ovid MEDLINE and Ovid EMBASE databases were searched for publications from 1980 to 2019 regarding ocular effects of drug use. The selected papers regarded human subjects, in either teenage or adult population and included all types of studies, including case reports. Publications in English or in French were included. Exclusion criteria were publications about the use of prescriptions drugs, drug withdrawal, and publications about the use of alcohol, tobacco, or cannabis. Some 241 papers were retained and analysed. The use of various drugs and substances can lead to damage to structures throughout the eye, including but not limited to corneal conditions, glaucoma and other optic neuropathies, maculopathies and endophthalmitis. The data presented in this review may help guide clinicians in their diagnosis and treatment of certain ocular conditions, which could otherwise not be linked to drug use.
“…Substanzen. Der kaukasische [28], normotone [27,29] Patient war Nichtraucher [30] und betrieb keinen Missbrauch psychotroper Substanzen [31]. vermehrten psychologischen Problemen [34,35] in Zusammenhang gebracht.…”
Central serous chorioretinitis serosa is repeatedly brought into aetiological considerations with a rather unspecific concept of distress. Depressive disorder represents a specific stressor, which is known in cardiology or diabetology as a significant risk factor. In the present case report, the clinical correlation between a central serous chorioretinitis and a depressive disorder is shown from a psychosomatic point of view, comparing a sequentially-reactive understanding of the disorder complex with a preferable model of simultaneous entanglement.
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