An Unusual Case of Cavernous Hemangioma of the Rib in a Young Man with Lung Tuberculosis: A Brief Review and Case Report

Oruc, Memduh; Atay, Ahmet Engin; Karabulut, Pervin; Paşa, Semir; Elbey, Ahmet; Ekin, Nazım; Yıldırım, Serdar

doi:10.2169/internalmedicine.52.9212

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…Cavernous haemangiomas usually occur in the skin, subcutaneous tissue, and muscles, but can also appear in the liver, kidneys, bones, and bladder; However, cavernous haemangiomas in the lungs are rare ( 3 ). Radiologically, lesions of PCHs can be isolated or multiple; diffuse pulmonary cavernous haemangiomas may be associated with hereditary haemorrhagic telangiectasia (HHT), which is a rare autosomal dominant genetic disorder characterised by recurrent epistaxis, cutaneous and mucosal telangiectasias, and arteriovenous malformations in visceral organs, including the liver, lungs, brain, and gastrointestinal tract ( 4 ). The pathogenesis is mainly associated with mutations in the ENG, ACVRL1 (also known as ALK1), and Smad4 genes ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

Multiple pulmonary cavernous haemangiomas with concurrent primary pulmonary adenocarcinoma: a case report and literature review

Wang,

Ren,

You

et al. 2024

Front. Oncol.

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BackgroundCavernous haemangiomas (CHs) commonly occurred in the skin, subcutaneous tissue, muscles, and liver. Pulmonary cavernous haemangiomas (PCHs) are quite rare and usually present with nonspecific clinical symptoms. When lung cancer patients are complicated with pulmonary cavernous haemangiomas, radiologically, these haemangioma lesions can be easily misinterpreted as intrapulmonary metastases, potentially resulting in misdiagnosis, or missed diagnosis.Case presentationThe present study reported the case of a 53−year−old female patient with pulmonary adenocarcinoma coexisting with multiple PCHs. 18F−FDG-Positron emission tomography-computed tomography (PET-CT) showed an elevated glucose metabolism in the apicoposterior segment of the left upper lobe; however, the other nodules were not hypermetabolic. Percutaneous lung biopsy was performed on the nodule in the apicoposterior segment of the left upper lobe, which were diagnosed as primary adenocarcinoma. Some nodules in the upper left lobe underwent wedge resection by video-assisted thoracic surgery (VATS) and intraoperative frozen section identified as PCHs. Finally, the patient underwent lobectomy of the left upper lobe via VATS, cancerous nodule in the apicoposterior segment of the left upper lobe underwent genetic molecular testing of PCR−Sanger sequencing, suggested EGFR mutation, and patient received treatment with Osimertinib. During the 4−months follow−up, contrast−enhanced CT showed no recurrence of either disease. PCHs are rare benign tumours of the lung, which can lead to misdiagnosis due to their non-specific clinical symptoms and radiological features, especially when they coexist with lung cancer. PCHs is easily misunderstood as metastatic lung cancer, in this case, PET-CT can assist in differentiating benign from malignant. For the cases of early lung cancer complicated with PCHs, lung cancer can be surgically resected, and whether PCHs should be removed or not should be determined according to the size and distribution of the lesions.

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Section: Discussionmentioning

confidence: 99%

Multiple pulmonary cavernous haemangiomas with concurrent primary pulmonary adenocarcinoma: a case report and literature review

Wang,

Ren,

You

et al. 2024

Front. Oncol.

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“…There are, however, certain imaging findings that are also seen in tumors that are malignant, such as chondrosarcomas or Ewing sarcomas. There may not be useful information available from PET/CT to differentiate a malignant tumor from a rib hemangioma due to the rib hemangiomas' higher 18 FDG uptake (30).…”

Section: Figurementioning

confidence: 99%

Case Report: Cavernous hemangioma of rib: an extremely rare venous malformation but easily misdiagnosed as aggressive tumors

Liu

Xiang²,

Ding³

et al. 2023

Front. Oncol.

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Hemangioma is a congenital vascular malformation that occurs commonly in the skin and soft tissues of younger individuals but rarely in the bone. The term hemangioma occurring in bone has been referred to as venous bony malformation also. In these rare cases, vertebral bodies occur more often, followed by the craniofacial skeleton and long bones. Most rib tumors are malignant, and hemangiomas of the rib tend to grow expansively and disrupt the cortex. Venous malformations in ribs are not tumors but can be misdiagnosed as aggressive tumors or infectious processes. In fact, hemangioma of bone is a locally aggressive benign vascular malformation associated with a good prognosis. To date, no more than 50 cases of rib hemangiomas have been described in the English literature. This report presents a case of an asymptomatic 27-year-old female patient who found a quail egg-sized lump on the right side of her chest that was the size of a cocoon 2 months prior. Then, the lump grew rapidly to the size of an egg when she presented to the hospital. Because of its worrisome histomorphologic features and aggressive clinical radiologic findings, it was once misdiagnosed as a malignant tumor by most doctors. However, the pathological results after the operation confirmed rib hemangioma. Therefore, this case report aims to share this particular case so that more doctors can better understand the particularity of this disease’s progression.

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“…These rare, slow growing neoplasms may occur at any age, and account for ~1% of bone tumors (3)(4)(5). Hemangiomas may occur in any bone of the body, most commonly in the spine, craniofacial bone, skull, ribs and long bones (6)(7)(8)(9)(10)(11)(12)(13)(14)(15); however, occurrence in the scapula is extremely rare. Hemangiomas of the long bone or flat bone commonly have a 'foam' or 'honeycomb' appearance (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

“…Hemangiomas of the long bone or flat bone commonly have a 'foam' or 'honeycomb' appearance (16)(17)(18). Bone hemangiomas disrupt the cortex and commonly grow expansively, which may result in the lesions being misdiagnosed as aggressive tumors or osteofibrous dysplasia and infectious processes (9,19). At present, treatments include radiotherapy, surgery and vascular embolization (1).…”

Section: Introductionmentioning

confidence: 99%

A rare case of pure primary hemangioma of the scapula: A case report

Zou

Dai

et al. 2015

Oncology Letters

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Abstract. Hemangioma is a benign vascular tumor, which may occur in any bone of the body. The most common locations are the spine and craniofacial bone; however, occurrence is extremely rare in the scapula. The current study presented the case of a 58-year-old female, with scapula hemangioma in the left shoulder who presented with joint ache that had lasted for ~1 year. The main clinical manifestations included local tenderness, an osseous lump and limited shoulder movement with a little pain, which was alleviated by rest. Roentgenogram, computed tomography and magnetic resonance imaging of the left acromion revealed a mass along the inner surface of the scapula of the left shoulder with polycystic expansion and bone destruction. The results of computed tomography and magnetic resonance imaging indicated a pure primary tumor and the lesion was subsequently resected. Notably, the postoperative pathological diagnosis was capillary hemangioma. The aim of the present study was to analyze the clinical and imaging features of scapula hemangioma, which must be considered for the differential diagnosis of scapula tumors. In the present case, no recurrence was identified by X-ray examination 1 year after surgery. The long-term efficacy of surgical treatment requires continuous observation of the patient. IntroductionBone hemangiomas are benign lesions originating from new capillaries or cavernous vascular vessels located in the bone. They are characterized by an increased number of normal or abnormal blood vessels. Bone hemangiomas are initially asymptomatic, however, as the tumor grows local pain is often experienced (1). Degradation can occur during the growth of hemangioma (2). These rare, slow growing neoplasms may occur at any age, and account for ~1% of bone tumors (3-5). Hemangiomas may occur in any bone of the body, most commonly in the spine, craniofacial bone, skull, ribs and long bones (6-15); however, occurrence in the scapula is extremely rare. Hemangiomas of the long bone or flat bone commonly have a 'foam' or 'honeycomb' appearance (16-18). Bone hemangiomas disrupt the cortex and commonly grow expansively, which may result in the lesions being misdiagnosed as aggressive tumors or osteofibrous dysplasia and infectious processes (9,19). At present, treatments include radiotherapy, surgery and vascular embolization (1). In the present study, a rare case of a capillary hemangioma of the scapula, which proved difficult to diagnose, was presented.To the best of our knowledge, this is the first case of pure primary hemangioma of the scapula that was misdiagnosed as an osteofibrous dysplasia (20) and treated with surgery. Case reportIn June 2013, a 58 year-old female presented at the First Affiliated Hospital of Nanchang University (Nanchang, China) with intermittent/repeated left shoulder pain, which had lasted for ~1 year. The main clinical manifestations included local tenderness, an osseous lump and limited shoulder movement with a little pain, which was alleviated by rest. The patient was referred to the Depa...

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An Unusual Case of Cavernous Hemangioma of the Rib in a Young Man with Lung Tuberculosis: A Brief Review and Case Report

Cited by 5 publications

References 12 publications

Multiple pulmonary cavernous haemangiomas with concurrent primary pulmonary adenocarcinoma: a case report and literature review

Multiple pulmonary cavernous haemangiomas with concurrent primary pulmonary adenocarcinoma: a case report and literature review

Case Report: Cavernous hemangioma of rib: an extremely rare venous malformation but easily misdiagnosed as aggressive tumors

A rare case of pure primary hemangioma of the scapula: A case report

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